Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) TsdAT/-
Location 2705464..2705984 Replicon chromosome
Accession NZ_CP012968
Organism Staphylococcus sp. AntiMn-1 isolate deep-sea sediment of east Pacific Nodule Province

Toxin (Protein)


Gene name TsdT Uniprot ID A0A192F7F2
Locus tag AOB58_RS13080 Protein ID WP_031266142.1
Coordinates 2705772..2705984 (+) Length 71 a.a.

Antitoxin (Protein)


Gene name TsdA Uniprot ID J9GWP4
Locus tag AOB58_RS13075 Protein ID WP_002507096.1
Coordinates 2705464..2705757 (+) Length 98 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
AOB58_RS13050 2700601..2701392 + 792 WP_064783598.1 hydroxyethylthiazole kinase -
AOB58_RS13055 2701392..2702030 + 639 WP_064783565.1 thiamine phosphate synthase -
AOB58_RS13060 2702118..2702987 + 870 WP_002507093.1 membrane protein insertase YidC -
AOB58_RS13065 2703058..2703708 - 651 WP_064783566.1 HD domain-containing protein -
AOB58_RS13070 2703836..2705320 - 1485 WP_021339943.1 cardiolipin synthase -
AOB58_RS13075 2705464..2705757 + 294 WP_002507096.1 copper-sensing transcriptional repressor CsoR Antitoxin
AOB58_RS13080 2705772..2705984 + 213 WP_031266142.1 heavy-metal-associated domain-containing protein Toxin
AOB58_RS13485 2706198..2706338 + 141 WP_002507098.1 hypothetical protein -
AOB58_RS13085 2706494..2707696 - 1203 WP_002507099.1 rod shape-determining protein RodA -
AOB58_RS13090 2707971..2709041 + 1071 WP_002507100.1 D-alanine--D-alanine ligase -
AOB58_RS13095 2709054..2710409 + 1356 WP_064783567.1 UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D- alanine ligase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Heavy metal-associated domain, HMA

(18-67)

Antitoxin

Metal-sensitive transcriptional repressor

(14-92)


Sequences

Toxin        


Download         Length: 71 a.a.        Molecular weight: 8116.13 Da        Isoelectric Point: 4.5086

>T57516 WP_031266142.1 NZ_CP012968:2705772-2705984 [Staphylococcus sp. AntiMn-1]
VVTKVIYISGIENETQQKHIEQQLKQLHGVHQVNIEIESNNGKIFIDFETPASLNNLEKEVYDLGYEILY

Download         Length: 213 bp

>T57516 NZ_CP012968:2705772-2705984 [Staphylococcus sp. AntiMn-1]
GTGGTAACAAAAGTTATTTATATTTCCGGTATAGAAAATGAAACACAACAAAAACATATTGAACAGCAGCTTAAGCAATT
ACACGGTGTACACCAAGTCAACATAGAAATAGAAAGCAATAATGGCAAAATTTTCATTGATTTTGAAACCCCTGCAAGTT
TAAATAATTTAGAAAAAGAAGTTTATGATTTAGGATATGAAATTTTATATTAA

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 11195.87 Da        Isoelectric Point: 6.4791

>AT57516 WP_002507096.1 NZ_CP012968:2705464-2705757 [Staphylococcus sp. AntiMn-1]
MAEIQKAHHSEQIKSNLKSRLNRIEGQVRAINRMVDEDVYCDDVLTQIRATRSALNGVATKLLDHHMKSCIMEKVEQGQQ
EEAMEELLVTFQKLMKD

Download         Length: 294 bp

>AT57516 NZ_CP012968:2705464-2705757 [Staphylococcus sp. AntiMn-1]
ATGGCGGAAATACAAAAAGCGCATCACTCAGAACAAATTAAATCTAATTTAAAATCAAGATTAAATCGTATAGAAGGCCA
AGTGAGAGCAATTAATCGCATGGTAGATGAAGATGTTTATTGTGATGACGTGCTCACACAAATTAGAGCCACTCGATCGG
CTTTAAATGGTGTTGCTACTAAATTATTAGACCATCATATGAAAAGTTGTATTATGGAAAAAGTAGAGCAGGGTCAACAA
GAAGAAGCTATGGAAGAACTATTGGTTACATTTCAAAAATTAATGAAGGATTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A192F7F2

Antitoxin

Source ID Structure
AlphaFold DB J9GWP4

References