57505

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/COG3657-dnstrm_HI1420
Location 2111343..2111935 Replicon chromosome
Accession NZ_CP012959
Organism Aggregatibacter actinomycetemcomitans strain 624

Toxin (Protein)


Gene name relE Uniprot ID -
Locus tag ACT75_RS10300 Protein ID WP_005542431.1
Coordinates 2111343..2111642 (+) Length 100 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID -
Locus tag ACT75_RS10305 Protein ID WP_005542432.1
Coordinates 2111639..2111935 (+) Length 99 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
ACT75_RS10275 2106619..2107833 - 1215 WP_005542426.1 molybdopterin molybdotransferase MoeA -
ACT75_RS10280 2107962..2108618 + 657 WP_005542427.1 GTP cyclohydrolase I FolE -
ACT75_RS10285 2108719..2110161 - 1443 WP_005542428.1 serine-type D-Ala-D-Ala carboxypeptidase -
ACT75_RS10290 2110321..2110797 + 477 WP_005542429.1 transcription elongation factor GreA -
ACT75_RS10295 2110873..2111175 - 303 WP_005542430.1 ribosome assembly RNA-binding protein YhbY -
ACT75_RS10300 2111343..2111642 + 300 WP_005542431.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
ACT75_RS10305 2111639..2111935 + 297 WP_005542432.1 putative addiction module antidote protein Antitoxin
ACT75_RS10310 2111968..2112582 - 615 WP_005542433.1 riboflavin synthase -
ACT75_RS10315 2112609..2114006 + 1398 WP_005542434.1 MATE family efflux transporter -
ACT75_RS10320 2114278..2116416 + 2139 WP_005542435.1 TonB-dependent siderophore receptor -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Integrative and Conjugative Element - hlyC / hlyB / hlyD / lsgD / lsgE / lsgF / kdsA 1942964..2134107 191143


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Addiction module killer protein, predicted

(4-97)

Antitoxin

Cro/C1-type helix-turn-helix domain

(46-90)


Sequences

Toxin        


Download         Length: 100 a.a.        Molecular weight: 11407.47 Da        Isoelectric Point: 10.4825

>T57505 WP_005542431.1 NZ_CP012959:2111343-2111642 [Aggregatibacter actinomycetemcomitans]
MMIQIKTTFLFDEWLKKLKNLRAKAKINARIKRLQFGNFGDLKSVNDGIFEMRIDEGQGYRVYLKNQNGILVILLCGGDK
STQEKDIKKAKQLAQEMGL

Download         Length: 300 bp

>T57505 NZ_CP012959:2111343-2111642 [Aggregatibacter actinomycetemcomitans]
ATGATGATACAAATTAAGACGACTTTTCTTTTTGATGAATGGTTGAAGAAACTCAAAAACCTAAGAGCCAAAGCAAAAAT
CAACGCACGAATTAAACGGTTACAGTTTGGTAATTTCGGTGATTTAAAAAGCGTTAATGACGGCATATTTGAAATGCGGA
TTGATGAAGGTCAGGGGTATCGGGTTTATCTGAAAAATCAAAATGGCATACTTGTTATCTTGCTTTGTGGCGGAGATAAA
TCCACTCAAGAGAAAGATATTAAGAAAGCAAAACAACTTGCACAGGAAATGGGACTATGA

Antitoxin


Download         Length: 99 a.a.        Molecular weight: 10852.32 Da        Isoelectric Point: 4.3776

>AT57505 WP_005542432.1 NZ_CP012959:2111639-2111935 [Aggregatibacter actinomycetemcomitans]
MSEQLKNFDPAEYLSTEEDIQLYLNEVLQENNIELILSALGDIARARNMSQIARETGMSREGLYKALSGTGNPTFATVIK
VMKALNLQLQVQPSGYAS

Download         Length: 297 bp

>AT57505 NZ_CP012959:2111639-2111935 [Aggregatibacter actinomycetemcomitans]
ATGAGTGAACAATTGAAAAATTTTGATCCTGCAGAATATTTATCTACCGAAGAAGATATTCAGCTTTATTTAAATGAAGT
GCTACAGGAAAATAATATTGAGCTTATTTTGTCTGCGTTAGGCGATATTGCACGAGCCAGAAATATGAGCCAAATTGCCC
GCGAAACCGGTATGAGTAGAGAAGGGCTTTATAAAGCCCTGTCCGGTACGGGCAATCCTACCTTTGCCACCGTGATTAAA
GTCATGAAAGCCTTAAATTTACAACTCCAAGTGCAACCTTCCGGTTACGCTTCTTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References