57503

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/YoeB-YefM
Location 2081747..2082249 Replicon chromosome
Accession NZ_CP012959
Organism Aggregatibacter actinomycetemcomitans strain 624

Toxin (Protein)


Gene name relB Uniprot ID A0A5D0ELP0
Locus tag ACT75_RS10135 Protein ID WP_005549367.1
Coordinates 2081747..2082001 (-) Length 85 a.a.

Antitoxin (Protein)


Gene name relE Uniprot ID A0A5D0ELA5
Locus tag ACT75_RS10140 Protein ID WP_005552753.1
Coordinates 2081998..2082249 (-) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
ACT75_RS10120 2077681..2079855 + 2175 WP_005542219.1 DNA helicase II -
ACT75_RS10125 2079987..2080814 - 828 WP_005542220.1 DNA ligase -
ACT75_RS10130 2080991..2081734 - 744 WP_005542222.1 YdcF family protein -
ACT75_RS10135 2081747..2082001 - 255 WP_005549367.1 Txe/YoeB family addiction module toxin Toxin
ACT75_RS10140 2081998..2082249 - 252 WP_005552753.1 type II toxin-antitoxin system prevent-host-death family antitoxin Antitoxin
ACT75_RS10145 2082358..2083314 - 957 WP_005542226.1 polysaccharide pyruvyl transferase family protein -
ACT75_RS10150 2083311..2084834 - 1524 WP_005542228.1 hypothetical protein -
ACT75_RS10155 2084968..2085741 + 774 WP_180267045.1 glycosyltransferase family 25 protein -
ACT75_RS10160 2085750..2086940 + 1191 WP_005549375.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Integrative and Conjugative Element - hlyC / hlyB / hlyD / lsgD / lsgE / lsgF / kdsA 1942964..2134107 191143


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(1-84)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-73)


Sequences

Toxin        


Download         Length: 85 a.a.        Molecular weight: 10203.68 Da        Isoelectric Point: 8.8844

>T57503 WP_005549367.1 NZ_CP012959:c2082001-2081747 [Aggregatibacter actinomycetemcomitans]
MILAWTETAWEDYLYWQQVDKKTLVRINKLIQNITRSPFEGLGNPEPLKHQLSGFWSRRIDKEHRLVYQVSDSHLTIIQC
RYHY

Download         Length: 255 bp

>T57503 NZ_CP012959:c2082001-2081747 [Aggregatibacter actinomycetemcomitans]
ATGATTTTAGCTTGGACAGAAACCGCCTGGGAAGATTATCTTTATTGGCAGCAAGTTGATAAAAAGACGTTGGTGCGCAT
TAATAAACTTATCCAAAATATTACCAGATCACCTTTCGAAGGCTTAGGCAATCCTGAACCTTTAAAACATCAGTTATCCG
GGTTTTGGTCTAGAAGAATAGATAAAGAGCATCGTCTTGTATACCAAGTATCGGATAGCCATTTAACGATTATTCAATGC
CGCTATCACTACTAA

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9414.65 Da        Isoelectric Point: 5.0637

>AT57503 WP_005552753.1 NZ_CP012959:c2082249-2081998 [Aggregatibacter actinomycetemcomitans]
MNVISYSAFRAELATTLDQVVADHSPVMITRQNGKHAVVMSLEDFAAYEETAYLLRSPKNRERLLASIDQFNSGKIVERE
LQE

Download         Length: 252 bp

>AT57503 NZ_CP012959:c2082249-2081998 [Aggregatibacter actinomycetemcomitans]
ATGAATGTAATAAGTTATTCTGCGTTCCGTGCAGAATTAGCAACAACACTTGATCAGGTGGTTGCAGATCATAGTCCAGT
CATGATTACCAGACAAAATGGCAAACACGCTGTTGTAATGAGTTTAGAAGATTTCGCAGCTTACGAAGAAACGGCTTATT
TATTACGTAGTCCAAAAAATAGAGAGCGTTTGTTAGCCTCTATTGACCAGTTCAATTCAGGTAAAATCGTCGAACGGGAA
CTCCAGGAATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A5D0ELP0

Antitoxin

Source ID Structure
AlphaFold DB A0A5D0ELA5

References