57501

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-DnaT
Location 457853..458387 Replicon chromosome
Accession NZ_CP012959
Organism Aggregatibacter actinomycetemcomitans strain 624

Toxin (Protein)


Gene name relE Uniprot ID A0A142FYB7
Locus tag ACT75_RS02120 Protein ID WP_005540089.1
Coordinates 458097..458387 (+) Length 97 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID A0A5D0EPW1
Locus tag ACT75_RS02115 Protein ID WP_005540091.1
Coordinates 457853..458107 (+) Length 85 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
ACT75_RS11640 453699..453785 + 87 Protein_403 MerR family DNA-binding transcriptional regulator -
ACT75_RS02085 454042..454626 + 585 Protein_404 relaxase/mobilization nuclease domain-containing protein -
ACT75_RS02090 454686..456017 + 1332 WP_005594223.1 3-phosphoshikimate 1-carboxyvinyltransferase -
ACT75_RS02095 456105..456572 - 468 WP_005540098.1 ribonuclease HI -
ACT75_RS02100 456640..457401 + 762 WP_005540094.1 DNA polymerase III subunit epsilon -
ACT75_RS02115 457853..458107 + 255 WP_005540091.1 hypothetical protein Antitoxin
ACT75_RS02120 458097..458387 + 291 WP_005540089.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
ACT75_RS02125 458449..458787 - 339 WP_005540087.1 cupin domain-containing protein -
ACT75_RS02130 459128..459580 + 453 WP_005540084.1 YeeE/YedE family protein -
ACT75_RS02135 459751..461139 + 1389 WP_005540081.1 tRNA 5-hydroxyuridine modification protein YegQ -
ACT75_RS02140 461913..462548 + 636 WP_005540076.1 WYL domain-containing protein -
ACT75_RS02145 462587..462973 + 387 WP_005540074.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(6-83)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 97 a.a.        Molecular weight: 11509.34 Da        Isoelectric Point: 10.7396

>T57501 WP_005540089.1 NZ_CP012959:458097-458387 [Aggregatibacter actinomycetemcomitans]
MTYKLTFDKRALKEWQKLGDTIRQQFKNKLAERLENPRVPGDKLRGYQNLYKIKLRAAGYRLVYEVNDNQIYILVLSVGK
RNRLDAYKNAEFRQAR

Download         Length: 291 bp

>T57501 NZ_CP012959:458097-458387 [Aggregatibacter actinomycetemcomitans]
ATGACTTATAAACTCACTTTTGATAAAAGGGCTTTAAAAGAGTGGCAAAAGTTAGGCGATACCATACGCCAACAATTCAA
AAATAAACTTGCGGAACGCTTAGAAAATCCGAGAGTACCGGGCGACAAATTAAGAGGTTATCAAAACCTTTATAAAATCA
AACTCCGCGCAGCCGGTTATCGCTTAGTTTATGAAGTTAATGATAACCAAATTTATATTCTTGTTTTATCCGTGGGTAAA
CGGAATAGATTAGACGCATATAAAAACGCAGAATTCAGACAAGCTCGGTAA

Antitoxin


Download         Length: 85 a.a.        Molecular weight: 9275.49 Da        Isoelectric Point: 3.9645

>AT57501 WP_005540091.1 NZ_CP012959:457853-458107 [Aggregatibacter actinomycetemcomitans]
MAIHQILTQQAASITDLKRDPMGIAYASQDGAVAILNHNQPAFYCVTPALFEYFQNLVEDAELGRIAEERLATLDPIEVS
LDDL

Download         Length: 255 bp

>AT57501 NZ_CP012959:457853-458107 [Aggregatibacter actinomycetemcomitans]
ATGGCAATACATCAAATTTTGACACAACAAGCCGCAAGCATTACCGATTTAAAACGGGACCCAATGGGCATTGCGTACGC
AAGCCAAGATGGTGCCGTAGCCATATTAAACCATAACCAACCAGCCTTTTATTGCGTCACGCCTGCATTATTTGAATATT
TTCAAAATCTGGTAGAAGATGCAGAATTAGGCAGAATTGCTGAAGAGCGTCTGGCAACCCTTGATCCGATTGAGGTAAGC
CTTGATGACTTATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A142FYB7

Antitoxin

Source ID Structure
AlphaFold DB A0A5D0EPW1

References