Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/YafQ-RelB
Location 422037..422587 Replicon chromosome
Accession NZ_CP012959
Organism Aggregatibacter actinomycetemcomitans strain 624

Toxin (Protein)


Gene name relE Uniprot ID G4A7B4
Locus tag ACT75_RS01935 Protein ID WP_005539226.1
Coordinates 422321..422587 (+) Length 89 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID X2JQ67
Locus tag ACT75_RS01930 Protein ID WP_005539223.1
Coordinates 422037..422309 (+) Length 91 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
ACT75_RS01895 417913..418554 + 642 WP_005546457.1 sulfite exporter TauE/SafE family protein -
ACT75_RS01900 418569..419051 + 483 WP_005552667.1 redoxin family protein -
ACT75_RS01905 419183..419377 - 195 WP_005551806.1 integrase core domain-containing protein -
ACT75_RS01910 419408..419542 - 135 WP_005544187.1 hypothetical protein -
ACT75_RS01915 419549..419752 - 204 WP_005544186.1 IS3 family transposase -
ACT75_RS01920 419880..420053 + 174 WP_005552670.1 hypothetical protein -
ACT75_RS01925 420429..421781 + 1353 WP_061866524.1 anaerobic C4-dicarboxylate transporter DcuC -
ACT75_RS01930 422037..422309 + 273 WP_005539223.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
ACT75_RS01935 422321..422587 + 267 WP_005539226.1 type II toxin-antitoxin system mRNA interferase toxin, RelE/StbE family Toxin
ACT75_RS01940 422619..424178 + 1560 WP_005539229.1 glutamine-hydrolyzing GMP synthase -
ACT75_RS01945 424571..425521 - 951 WP_005539231.1 hypothetical protein -
ACT75_RS01950 425715..426128 - 414 WP_005539234.1 hydroxyisourate hydrolase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, YafQ-like toxin

(5-88)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-85)


Sequences

Toxin        


Download         Length: 89 a.a.        Molecular weight: 10502.03 Da        Isoelectric Point: 7.2393

>T57500 WP_005539226.1 NZ_CP012959:422321-422587 [Aggregatibacter actinomycetemcomitans]
MDYVLSKEYKRDLKKLPVEIQSGPEYAEVLYCLFNQKSLPERYKDHALQGNWQGFRDCHIKNDLVLIYKIEADTLYFARL
NSHSEVFK

Download         Length: 267 bp

>T57500 NZ_CP012959:422321-422587 [Aggregatibacter actinomycetemcomitans]
ATGGATTACGTTTTATCAAAAGAATATAAACGGGACTTAAAAAAACTTCCGGTCGAAATTCAATCCGGTCCGGAATATGC
AGAGGTTTTATATTGCCTGTTCAATCAAAAATCCCTACCCGAACGATATAAAGATCATGCTTTGCAAGGAAATTGGCAGG
GATTTCGAGATTGCCACATCAAAAATGATCTCGTTTTAATTTACAAAATAGAAGCAGACACCCTCTATTTTGCAAGGCTA
AATTCTCACTCGGAAGTGTTTAAATAA

Antitoxin


Download         Length: 91 a.a.        Molecular weight: 10147.52 Da        Isoelectric Point: 6.2633

>AT57500 WP_005539223.1 NZ_CP012959:422037-422309 [Aggregatibacter actinomycetemcomitans]
MLDSAVNFRTQADIKEQAFNVIKSYGLTPAQVLNMFLTQIAKTNTIPLSLDYQPNTKTANAINELMSGKGERFSVDSFDE
FQQKIRDLSK

Download         Length: 273 bp

>AT57500 NZ_CP012959:422037-422309 [Aggregatibacter actinomycetemcomitans]
ATGTTAGATAGCGCAGTGAATTTCCGTACTCAAGCCGACATCAAAGAGCAAGCGTTTAACGTCATTAAAAGCTATGGCTT
AACGCCCGCTCAGGTGTTAAATATGTTTTTGACCCAAATTGCCAAAACCAACACAATTCCGCTCAGTTTGGATTATCAGC
CGAATACAAAAACAGCTAATGCAATCAATGAATTAATGAGCGGAAAAGGGGAAAGATTTAGCGTAGATTCCTTTGATGAA
TTTCAACAAAAAATTCGTGATTTAAGCAAATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A142FY83

Antitoxin

Source ID Structure
AlphaFold DB X2JQ67

References