57498

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relE-PumB/upstrm_HI1419-dnstrm_HI1420
Location 62114..62711 Replicon chromosome
Accession NZ_CP012959
Organism Aggregatibacter actinomycetemcomitans strain 624

Toxin (Protein)


Gene name relE Uniprot ID A0A142FXE8
Locus tag ACT75_RS00285 Protein ID WP_005595366.1
Coordinates 62114..62416 (+) Length 101 a.a.

Antitoxin (Protein)


Gene name PumB Uniprot ID G4A710
Locus tag ACT75_RS00290 Protein ID WP_005556438.1
Coordinates 62418..62711 (+) Length 98 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
ACT75_RS00265 57472..58221 - 750 WP_005538836.1 hypothetical protein -
ACT75_RS00270 58225..58437 - 213 WP_005538838.1 hypothetical protein -
ACT75_RS11545 58572..58808 - 237 WP_005538841.1 hypothetical protein -
ACT75_RS12285 58763..59974 - 1212 WP_061866516.1 hypothetical protein -
ACT75_RS00280 60015..61961 - 1947 WP_005538140.1 ABC transporter ATP-binding protein -
ACT75_RS00285 62114..62416 + 303 WP_005595366.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
ACT75_RS00290 62418..62711 + 294 WP_005556438.1 putative addiction module antidote protein Antitoxin
ACT75_RS00295 62748..64100 - 1353 WP_005538151.1 deoxyguanosinetriphosphate triphosphohydrolase family protein -
ACT75_RS00300 64102..64794 - 693 WP_005538152.1 CidB/LrgB family autolysis modulator -
ACT75_RS00305 64794..65204 - 411 WP_005538154.1 CidA/LrgA family protein -
ACT75_RS00315 65780..66781 + 1002 WP_061866595.1 site-specific integrase -
ACT75_RS12820 66891..67070 - 180 WP_005538158.1 helix-turn-helix domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 62114..71342 9228


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Addiction module killer protein, predicted

(1-97)

Antitoxin

Cro/C1-type helix-turn-helix domain

(47-89)


Sequences

Toxin        


Download         Length: 101 a.a.        Molecular weight: 11413.93 Da        Isoelectric Point: 5.8716

>T57498 WP_005595366.1 NZ_CP012959:62114-62416 [Aggregatibacter actinomycetemcomitans]
MYIIEETEEFSNWLENLTDELAIVNIVARIERAKLGNFGDHKSVGNGVYEMRITKGKGYRIYYARKGGITYLLILGGDKS
SQEQDIQNAKALWQQIKNGE

Download         Length: 303 bp

>T57498 NZ_CP012959:62114-62416 [Aggregatibacter actinomycetemcomitans]
ATGTATATAATTGAGGAAACGGAGGAATTCTCCAACTGGTTAGAGAATCTAACCGACGAACTTGCGATTGTGAATATTGT
TGCTCGAATCGAAAGGGCAAAGCTCGGCAATTTCGGTGATCATAAATCGGTGGGTAATGGCGTATATGAAATGCGAATTA
CAAAAGGGAAAGGCTATAGGATCTACTATGCCAGAAAAGGGGGTATTACTTATCTATTGATTCTTGGTGGCGATAAGTCA
AGCCAAGAACAAGATATTCAGAATGCAAAAGCACTATGGCAACAGATTAAAAACGGAGAATAA

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 10694.39 Da        Isoelectric Point: 6.3545

>AT57498 WP_005556438.1 NZ_CP012959:62418-62711 [Aggregatibacter actinomycetemcomitans]
MTVTTREFDAARYLKNEKMMAMYLETVLEEGTTAEFIQALNTVARAKGMSELAEKTGIGRESLYKTLSSEKPRFDTILKI
ISALGLSLSINAKDAVA

Download         Length: 294 bp

>AT57498 NZ_CP012959:62418-62711 [Aggregatibacter actinomycetemcomitans]
ATGACAGTAACAACCCGAGAATTTGATGCAGCGCGTTATTTGAAAAATGAAAAAATGATGGCAATGTATCTTGAAACAGT
TTTAGAAGAAGGCACAACGGCTGAGTTTATACAAGCTCTGAATACGGTCGCAAGAGCAAAGGGCATGTCGGAACTGGCGG
AAAAAACCGGCATCGGACGTGAAAGTTTGTACAAAACCCTATCAAGTGAAAAACCACGTTTTGACACGATTCTAAAAATT
ATTTCAGCATTGGGGCTTAGCCTTTCTATTAATGCTAAAGATGCAGTAGCCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A142FXE8

Antitoxin

Source ID Structure
AlphaFold DB A0A142FXE9

References