Detailed information of TA system TA057497

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/ParE-DnaT
• Location: 1221063..1221597
• Replicon: chromosome
• Accession: NZ_CP012958
• Organism: Aggregatibacter actinomycetemcomitans strain VT1169

Toxin (Protein)

• Gene name: relE
• Uniprot ID: A0A142FYB7
• Locus tag: ACT74_RS05735
• Protein ID: WP_005540089.1
• Coordinates: 1221307..1221597 (+)
• Length: 97 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: -
• Locus tag: ACT74_RS05730
• Protein ID: WP_005545663.1
• Coordinates: 1221063..1221317 (+)
• Length: 85 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
ACT74_RS10650	1216909..1216995	+	87	Protein_1109	MerR family DNA-binding transcriptional regulator	-
ACT74_RS05700	1217252..1217836	+	585	Protein_1110	relaxase/mobilization nuclease domain-containing protein	-
ACT74_RS05705	1217896..1219227	+	1332	WP_061869919.1	3-phosphoshikimate 1-carboxyvinyltransferase	-
ACT74_RS05710	1219315..1219782	-	468	WP_005565412.1	ribonuclease HI	-
ACT74_RS05715	1219850..1220611	+	762	WP_005567590.1	DNA polymerase III subunit epsilon	-
ACT74_RS05730	1221063..1221317	+	255	WP_005545663.1	stability protein StbD	Antitoxin
ACT74_RS05735	1221307..1221597	+	291	WP_005540089.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
ACT74_RS05740	1221654..1221995	-	342	WP_014167925.1	cupin domain-containing protein	-
ACT74_RS05745	1222336..1222788	+	453	WP_006710245.1	50S ribosomal protein L11 methyltransferase	-
ACT74_RS05750	1222959..1224347	+	1389	WP_005567594.1	tRNA 5-hydroxyuridine modification protein YegQ	-
ACT74_RS05755	1224644..1225735	+	1092	WP_014167926.1	tRNA preQ1(34) S-adenosylmethionine ribosyltransferase-isomerase QueA	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (6-83)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 97 a.a.
• Molecular weight: 11509.34 Da
• Isoelectric Point: 10.7396

>T57497 WP_005540089.1 NZ_CP012958:1221307-1221597 [Aggregatibacter actinomycetemcomitans]
MTYKLTFDKRALKEWQKLGDTIRQQFKNKLAERLENPRVPGDKLRGYQNLYKIKLRAAGYRLVYEVNDNQIYILVLSVGK
RNRLDAYKNAEFRQAR

Nucleotide

• Length: 291 bp

>T57497 NZ_CP012958:1221307-1221597 [Aggregatibacter actinomycetemcomitans]
ATGACTTATAAACTCACTTTTGATAAAAGGGCTTTAAAAGAGTGGCAAAAGTTAGGCGATACCATACGCCAACAATTCAA
AAATAAACTTGCGGAACGCTTAGAAAATCCGAGAGTACCGGGCGACAAATTAAGAGGTTATCAAAACCTTTATAAAATCA
AACTCCGCGCAGCCGGTTATCGCTTAGTTTATGAAGTTAATGATAACCAAATTTATATTCTTGTTTTATCCGTGGGTAAA
CGGAATAGATTAGACGCATACAAAAATGCAGAATTCAGACAAGCTCGGTAA

Antitoxin

Protein

• Length: 85 a.a.
• Molecular weight: 9294.53 Da
• Isoelectric Point: 3.9649

>AT57497 WP_005545663.1 NZ_CP012958:1221063-1221317 [Aggregatibacter actinomycetemcomitans]
MAIHQILTQQAASITDLKRDPMGIAYASQDGAVAILNRNQPAFYCVTPALFEYFQNLVEDAELGRIAEERLATLDPIEVS
LDDL

Nucleotide

• Length: 255 bp

>AT57497 NZ_CP012958:1221063-1221317 [Aggregatibacter actinomycetemcomitans]
ATGGCAATACATCAAATTTTGACACAACAAGCCGCAAGCATTACCGATTTAAAACGGGACCCAATGGGCATTGCGTACGC
AAGCCAAGATGGTGCCGTAGCCATATTAAACCGTAACCAACCAGCCTTTTATTGCGTCACGCCTGCATTATTTGAATATT
TTCAAAATCTGGTAGAAGATGCAGAATTAGGCAGAATTGCTGAAGAGCGTCTGGCAACCCTTGATCCGATTGAGGTAAGC
CTTGATGACTTATAA

Structures

Toxin

• AlphaFold DB: A0A142FYB7