Detailed information of TA system TA057495

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/YefM-YoeB
• Location: 1135729..1136231
• Replicon: chromosome
• Accession: NZ_CP012958
• Organism: Aggregatibacter actinomycetemcomitans strain VT1169

Toxin (Protein)

• Gene name: relE
• Uniprot ID: X2JX79
• Locus tag: ACT74_RS05370
• Protein ID: WP_005547296.1
• Coordinates: 1135729..1135980 (+)
• Length: 84 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: S4W640
• Locus tag: ACT74_RS05375
• Protein ID: WP_005556313.1
• Coordinates: 1135977..1136231 (+)
• Length: 85 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
ACT74_RS05350	1131035..1132228	-	1194	WP_005556328.1	hypothetical protein	-
ACT74_RS05355	1132237..1133010	-	774	WP_025298488.1	glycosyltransferase family 25 protein	-
ACT74_RS05360	1133144..1134667	+	1524	WP_061869913.1	hypothetical protein	-
ACT74_RS05365	1134664..1135620	+	957	WP_005556319.1	polysaccharide pyruvyl transferase family protein	-
ACT74_RS05370	1135729..1135980	+	252	WP_005547296.1	type II toxin-antitoxin system prevent-host-death family antitoxin	Toxin
ACT74_RS05375	1135977..1136231	+	255	WP_005556313.1	Txe/YoeB family addiction module toxin	Antitoxin
ACT74_RS05380	1136244..1136987	+	744	WP_005542222.1	YdcF family protein	-
ACT74_RS05385	1137164..1137991	+	828	WP_005556311.1	DNA ligase	-
ACT74_RS05390	1138124..1140298	-	2175	WP_005556309.1	DNA helicase II	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Type II toxin-antitoxin system, antitoxin Phd/YefM (1-73)

Antitoxin

• Toxin YoeB (1-84)

Sequences

Toxin

Protein

• Length: 84 a.a.
• Molecular weight: 9394.66 Da
• Isoelectric Point: 5.0637

>T57495 WP_005547296.1 NZ_CP012958:1135729-1135980 [Aggregatibacter actinomycetemcomitans]
MNVISYSAFRAELATTLDQVVADHSPVMITRQNGKHAVVMSLEDFAAYEETAYLLRSPKNRERLLASIDQLNSGKIIERE
LQE

Nucleotide

• Length: 252 bp

>T57495 NZ_CP012958:1135729-1135980 [Aggregatibacter actinomycetemcomitans]
ATGAATGTAATAAGTTATTCTGCGTTTCGTGCAGAATTGGCAACCACACTTGATCAGGTGGTAGCAGATCATAGCCCAGT
CATGATTACCAGACAAAATGGCAAACACGCTGTTGTAATGAGTTTAGAAGATTTCGCAGCTTACGAAGAAACGGCTTATT
TATTACGCAGCCCCAAAAATAGAGAGCGTTTATTAGCCTCTATTGACCAGCTCAATTCAGGTAAAATCATCGAACGGGAA
CTCCAGGAATGA

Antitoxin

Protein

• Length: 85 a.a.
• Molecular weight: 10217.71 Da
• Isoelectric Point: 8.8844

>AT57495 WP_005556313.1 NZ_CP012958:1135977-1136231 [Aggregatibacter actinomycetemcomitans]
MILAWTETAWEDYLYWQQVDKKTLLRINKLIQNITRSPFEGLGNPEPLKHQLSGFWSRRIDKEHRLVYQVSDSHLTIIQC
RYHY

Nucleotide

• Length: 255 bp

>AT57495 NZ_CP012958:1135977-1136231 [Aggregatibacter actinomycetemcomitans]
ATGATTTTAGCTTGGACGGAAACCGCCTGGGAAGATTATCTTTATTGGCAGCAAGTTGATAAAAAGACGTTGTTGCGCAT
TAATAAACTTATCCAAAATATTACCAGATCACCTTTCGAAGGCTTAGGCAATCCTGAACCTTTAAAACATCAGTTATCCG
GGTTTTGGTCTAGAAGAATAGATAAAGAGCATCGTCTTGTATACCAAGTATCGGATAGCCATTTAACGATTATTCAATGC
CGCTATCACTACTAA

Structures

Toxin

• AlphaFold DB: X2JX79

Antitoxin

• AlphaFold DB: S4W640