Detailed information of TA system TA057493

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/YafQ-RelB
• Location: 580508..581058
• Replicon: chromosome
• Accession: NZ_CP012958
• Organism: Aggregatibacter actinomycetemcomitans strain VT1169

Toxin (Protein)

• Gene name: relE
• Uniprot ID: -
• Locus tag: ACT74_RS02825
• Protein ID: WP_014167746.1
• Coordinates: 580508..580774 (-)
• Length: 89 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: X2JQ67
• Locus tag: ACT74_RS02830
• Protein ID: WP_005539223.1
• Coordinates: 580786..581058 (-)
• Length: 91 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
ACT74_RS02805	575963..577129	+	1167	WP_005590091.1	phage tail protein	-
ACT74_RS02810	577129..577740	+	612	WP_005590093.1	DUF4376 domain-containing protein	-
ACT74_RS02815	577893..578711	-	819	WP_196755600.1	integrase arm-type DNA-binding domain-containing protein	-
ACT74_RS02820	578917..580476	-	1560	WP_005590096.1	glutamine-hydrolyzing GMP synthase	-
ACT74_RS02825	580508..580774	-	267	WP_014167746.1	type II toxin-antitoxin system mRNA interferase toxin, RelE/StbE family	Toxin
ACT74_RS02830	580786..581058	-	273	WP_005539223.1	type II toxin-antitoxin system RelB/DinJ family antitoxin	Antitoxin
ACT74_RS02835	581313..582665	-	1353	WP_005545994.1	anaerobic C4-dicarboxylate transporter DcuC	-
ACT74_RS02845	583103..583558	+	456	WP_005569409.1	ribosome maturation factor RimP	-
ACT74_RS02850	583582..585078	+	1497	WP_005569410.1	transcription termination/antitermination protein NusA	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (5-87)

Antitoxin

• RelB antitoxin/Antitoxin DinJ (1-85)

Sequences

Toxin

Protein

• Length: 89 a.a.
• Molecular weight: 10516.05 Da
• Isoelectric Point: 7.2393

>T57493 WP_014167746.1 NZ_CP012958:c580774-580508 [Aggregatibacter actinomycetemcomitans]
MDYVLSKEYKRDLKKIPVEIQSGPEYAEVLYCLFNQKSLPERYKDHALQGNWQGFRDCHIKNDLILIYKIEADTLYFARL
NSHSEVFK

Nucleotide

• Length: 267 bp

>T57493 NZ_CP012958:c580774-580508 [Aggregatibacter actinomycetemcomitans]
ATGGATTACGTTTTATCAAAAGAATATAAACGGGACTTAAAAAAAATTCCGGTCGAAATTCAATCCGGTCCGGAATATGC
AGAGGTTTTATATTGCCTGTTCAATCAAAAATCCCTACCCGAACGATATAAAGATCATGCTTTGCAAGGAAATTGGCAGG
GATTTCGAGATTGCCACATCAAAAATGATCTCATTTTAATTTACAAAATAGAAGCAGACACCCTCTATTTTGCAAGGCTA
AATTCTCACTCGGAAGTGTTTAAATAA

Antitoxin

Protein

• Length: 91 a.a.
• Molecular weight: 10147.52 Da
• Isoelectric Point: 6.2633

>AT57493 WP_005539223.1 NZ_CP012958:c581058-580786 [Aggregatibacter actinomycetemcomitans]
MLDSAVNFRTQADIKEQAFNVIKSYGLTPAQVLNMFLTQIAKTNTIPLSLDYQPNTKTANAINELMSGKGERFSVDSFDE
FQQKIRDLSK

Nucleotide

• Length: 273 bp

>AT57493 NZ_CP012958:c581058-580786 [Aggregatibacter actinomycetemcomitans]
ATGTTAGATAGCGCAGTGAATTTCCGTACTCAAGCCGACATCAAAGAGCAAGCGTTTAACGTCATTAAAAGCTATGGCTT
AACGCCCGCTCAGGTGTTAAATATGTTTTTGACCCAAATTGCCAAAACCAACACAATTCCGCTCAGTTTGGATTATCAGC
CGAATACAAAAACAGCTAATGCAATCAATGAATTAATGAGCGGAAAAGGGGAAAGATTTAGCGTAGATTCCTTTGATGAA
TTTCAACAAAAAATTCGTGATTTAAGCAAATAA

Structures

Antitoxin

• AlphaFold DB: X2JQ67