Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/COG3657-dnstrm_HI1420
Location 412213..412805 Replicon chromosome
Accession NZ_CP012958
Organism Aggregatibacter actinomycetemcomitans strain VT1169

Toxin (Protein)


Gene name relE Uniprot ID -
Locus tag ACT74_RS01990 Protein ID WP_014167707.1
Coordinates 412213..412512 (+) Length 100 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID -
Locus tag ACT74_RS01995 Protein ID WP_005568148.1
Coordinates 412509..412805 (+) Length 99 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
ACT74_RS01965 407492..408706 - 1215 WP_061869832.1 molybdopterin molybdotransferase MoeA -
ACT74_RS01970 408835..409491 + 657 WP_005568155.1 GTP cyclohydrolase I FolE -
ACT74_RS01975 409592..411034 - 1443 WP_050846335.1 serine-type D-Ala-D-Ala carboxypeptidase -
ACT74_RS01980 411194..411670 + 477 WP_005572298.1 transcription elongation factor GreA -
ACT74_RS01985 411743..412045 - 303 WP_005568150.1 ribosome assembly RNA-binding protein YhbY -
ACT74_RS01990 412213..412512 + 300 WP_014167707.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
ACT74_RS01995 412509..412805 + 297 WP_005568148.1 putative addiction module antidote protein Antitoxin
ACT74_RS02000 412838..413452 - 615 WP_005568146.1 riboflavin synthase -
ACT74_RS02005 413479..414876 + 1398 WP_005592819.1 MATE family efflux transporter -
ACT74_RS02010 415180..415659 - 480 WP_005545251.1 Cys-tRNA(Pro) deacylase -
ACT74_RS02015 415720..416523 + 804 WP_005572988.1 aspartate-semialdehyde dehydrogenase -
ACT74_RS02020 416478..416957 + 480 Protein_392 extracellular solute-binding protein -
ACT74_RS02025 416932..417729 + 798 WP_005568139.1 ABC transporter permease -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(13-92)

Antitoxin

Uncharacterized protein HI1420

(5-91)


Sequences

Toxin        


Download         Length: 100 a.a.        Molecular weight: 11406.53 Da        Isoelectric Point: 10.6671

>T57490 WP_014167707.1 NZ_CP012958:412213-412512 [Aggregatibacter actinomycetemcomitans]
MMIQIKTTFLFDEWLKKLKNLRAKAKINARIKRLQFGNFGDLKSVNDGIFEMRIDKGQGYRVYLKNQNGILVILLCGGDK
STQEKDIKKAKQLAQEMGL

Download         Length: 300 bp

>T57490 NZ_CP012958:412213-412512 [Aggregatibacter actinomycetemcomitans]
ATGATGATACAAATTAAGACGACTTTTCTTTTTGATGAATGGTTGAAGAAACTCAAAAACCTAAGAGCTAAAGCAAAAAT
CAACGCACGAATTAAACGGTTACAGTTTGGTAATTTCGGTGATTTAAAAAGCGTTAATGACGGCATATTTGAAATGCGGA
TTGATAAAGGTCAGGGGTATCGGGTTTATCTGAAAAATCAAAATGGCATACTTGTTATCCTGCTTTGTGGCGGAGACAAA
TCCACTCAAGAGAAAGATATCAAGAAAGCAAAACAACTTGCACAGGAAATGGGACTATGA

Antitoxin


Download         Length: 99 a.a.        Molecular weight: 10939.44 Da        Isoelectric Point: 4.4155

>AT57490 WP_005568148.1 NZ_CP012958:412509-412805 [Aggregatibacter actinomycetemcomitans]
MSEQLKDFDPAEYLSTEEDIRLYLNEVLQENNIELILSALGDIARTRNMSQIARETGMSREGLYKALSGTGNPTFATVIK
VMKALNLQLQVQPSGYVS

Download         Length: 297 bp

>AT57490 NZ_CP012958:412509-412805 [Aggregatibacter actinomycetemcomitans]
ATGAGTGAACAATTGAAAGATTTTGATCCTGCAGAATATTTATCTACCGAAGAAGATATTCGGCTTTATTTAAATGAAGT
GCTACAAGAAAATAATATTGAGCTTATTTTGTCTGCGTTAGGCGATATCGCACGAACCAGAAATATGAGCCAAATTGCCC
GCGAAACCGGTATGAGTAGAGAAGGGCTTTATAAAGCCCTGTCCGGTACGGGCAATCCTACCTTTGCCACCGTGATTAAA
GTCATGAAAGCCTTAAATTTACAACTCCAAGTGCAACCTTCCGGTTATGTTTCTTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References