Detailed information of TA system TA057479

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hicAB/HicA-HicB
• Location: 1196317..1196792
• Replicon: chromosome
• Accession: NZ_CP012946
• Organism: Blastochloris viridis strain ATCC 19567

Toxin (Protein)

• Gene name: hicA
• Uniprot ID: -
• Locus tag: BVIR_RS05340
• Protein ID: WP_055038701.1
• Coordinates: 1196317..1196508 (+)
• Length: 64 a.a.

Antitoxin (Protein)

• Gene name: hicB
• Uniprot ID: A0A0P0ID03
• Locus tag: BVIR_RS05345
• Protein ID: WP_055036760.1
• Coordinates: 1196505..1196792 (+)
• Length: 96 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
BVIR_RS05305	1191822..1192124	-	303	WP_055038700.1	hypothetical protein	-
BVIR_RS05310	1192358..1193413	-	1056	WP_082417334.1	polysaccharide deacetylase family protein	-
BVIR_RS05315	1194067..1194282	+	216	WP_055036755.1	hypothetical protein	-
BVIR_RS05320	1194348..1194638	-	291	WP_055036756.1	hypothetical protein	-
BVIR_RS05325	1194798..1195238	+	441	WP_055036757.1	isoprenylcysteine carboxylmethyltransferase family protein	-
BVIR_RS05330	1195291..1195620	-	330	WP_058124826.1	hypothetical protein	-
BVIR_RS05335	1195865..1196212	+	348	WP_055036759.1	ArsC family reductase	-
BVIR_RS05340	1196317..1196508	+	192	WP_055038701.1	type II toxin-antitoxin system HicA family toxin	Toxin
BVIR_RS05345	1196505..1196792	+	288	WP_055036760.1	type II toxin-antitoxin system HicB family antitoxin	Antitoxin
BVIR_RS16690	1197263..1197706	-	444	WP_145911850.1	hypothetical protein	-
BVIR_RS05350	1197765..1198013	-	249	WP_055036761.1	DUF2442 domain-containing protein	-
BVIR_RS16695	1198325..1198837	-	513	WP_145911849.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HicA mRNA interferase family (3-59)

Antitoxin

• HicB-like antitoxin of toxin-antitoxin system (5-86)

Sequences

Toxin

Protein

• Length: 64 a.a.
• Molecular weight: 7255.39 Da
• Isoelectric Point: 10.9847

>T57479 WP_055038701.1 NZ_CP012946:1196317-1196508 [Blastochloris viridis]
IDSRDIIRLLEQDGWIYVGATGSHYHFRHPAKPGKVTVPHPRKDLHPKTARSIFRMAGLKEPR

Nucleotide

• Length: 192 bp

>T57479 NZ_CP012946:1196317-1196508 [Blastochloris viridis]
ATCGATTCACGCGATATCATCCGCCTGTTGGAGCAGGACGGGTGGATTTATGTGGGCGCCACCGGCAGCCACTACCACTT
CAGGCATCCGGCAAAGCCCGGCAAGGTCACCGTGCCTCACCCGCGCAAGGACTTGCATCCGAAGACCGCGCGATCGATCT
TTCGGATGGCGGGCTTGAAGGAGCCGCGATGA

Antitoxin

Protein

• Length: 96 a.a.
• Molecular weight: 9564.56 Da
• Isoelectric Point: 3.9005

>AT57479 WP_055036760.1 NZ_CP012946:1196505-1196792 [Blastochloris viridis]
MMAGYLALVHKDAGTSYGVSFPDVPGCVSAGDTLEEALANAAEALGGHLALLATDGDSVPSPRSFEALRADASLADEFED
AVVSFVQPHATASAA

Nucleotide

• Length: 288 bp

>AT57479 NZ_CP012946:1196505-1196792 [Blastochloris viridis]
ATGATGGCCGGTTATCTCGCATTGGTGCACAAGGACGCGGGCACGAGCTACGGCGTCAGCTTTCCGGACGTTCCGGGCTG
CGTGTCGGCTGGCGATACGCTGGAGGAAGCGCTGGCCAATGCGGCGGAGGCGCTTGGCGGACACCTCGCTTTGCTCGCCA
CCGATGGCGACTCGGTGCCGTCCCCGCGCAGCTTCGAAGCCTTGCGGGCGGATGCCAGCCTCGCCGACGAGTTTGAGGAT
GCGGTGGTGAGCTTCGTTCAGCCGCACGCCACCGCCTCGGCGGCCTGA

Structures

Antitoxin

• AlphaFold DB: A0A0P0ID03