Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/RHH(antitoxin)
Location 4417468..4418012 Replicon chromosome
Accession NZ_CP012945
Organism Devosia sp. A16

Toxin (Protein)


Gene name relE Uniprot ID -
Locus tag APS40_RS21185 Protein ID WP_055048930.1
Coordinates 4417788..4418012 (+) Length 75 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID -
Locus tag APS40_RS21180 Protein ID WP_055048929.1
Coordinates 4417468..4417737 (+) Length 90 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
APS40_RS25050 4412853..4413971 - 1119 WP_055048925.1 DNA-processing protein DprA -
APS40_RS25055 4413975..4414607 - 633 WP_055048926.1 glycerol-3-phosphate 1-O-acyltransferase PlsY -
APS40_RS21165 4414604..4415917 - 1314 WP_082434585.1 dihydroorotase -
APS40_RS21170 4415914..4416897 - 984 WP_055048927.1 aspartate carbamoyltransferase catalytic subunit -
APS40_RS21175 4416966..4417421 - 456 WP_055048928.1 Holliday junction resolvase RuvX -
APS40_RS21180 4417468..4417737 + 270 WP_055048929.1 ribbon-helix-helix protein, CopG family Antitoxin
APS40_RS21185 4417788..4418012 + 225 WP_055048930.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
APS40_RS21190 4418009..4418524 + 516 WP_055048931.1 hypothetical protein -
APS40_RS21195 4418607..4418894 + 288 WP_055048932.1 Asp-tRNA(Asn)/Glu-tRNA(Gln) amidotransferase subunit GatC -
APS40_RS21200 4418900..4419382 + 483 WP_055048933.1 GNAT family N-acetyltransferase -
APS40_RS21205 4419490..4420974 + 1485 WP_055048934.1 Asp-tRNA(Asn)/Glu-tRNA(Gln) amidotransferase subunit GatA -
APS40_RS21210 4421156..4421470 + 315 WP_055049769.1 hypothetical protein -
APS40_RS21215 4421532..4421789 - 258 WP_055048935.1 YjhX family toxin -
APS40_RS21220 4422096..4422404 + 309 WP_055048936.1 chorismate mutase -
APS40_RS21225 4422441..4422959 + 519 WP_055048937.1 GNAT family N-acetyltransferase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(10-73)

Antitoxin

Ribbon-helix-helix protein, CopG

(6-42)


Sequences

Toxin        


Download         Length: 75 a.a.        Molecular weight: 8529.04 Da        Isoelectric Point: 5.1186

>T57478 WP_055048930.1 NZ_CP012945:4417788-4418012 [Devosia sp. A16]
MLLSPVNELAAALVVRKLVSAPDKLLGMPRMGERVEEIPDREVRRMLAAPYELLYEVLSDEIAILRFLHNREDR

Download         Length: 225 bp

>T57478 NZ_CP012945:4417788-4418012 [Devosia sp. A16]
ATGCTTCTCAGCCCCGTCAACGAACTCGCCGCGGCGCTCGTGGTGCGAAAGCTGGTTTCGGCGCCAGATAAGCTCCTCGG
TATGCCGCGGATGGGCGAACGGGTCGAAGAGATCCCCGACCGGGAGGTGCGCCGCATGTTGGCCGCTCCCTACGAACTTC
TCTACGAAGTCCTTTCCGACGAAATTGCTATTCTTCGCTTCCTCCATAACCGGGAAGACCGATGA

Antitoxin


Download         Length: 90 a.a.        Molecular weight: 10222.61 Da        Isoelectric Point: 4.9001

>AT57478 WP_055048929.1 NZ_CP012945:4417468-4417737 [Devosia sp. A16]
MSTRVLTAHIPEELAEKVDRYAESMERSRAWIVKQALSNWVDWEEEKLRRTLEGLADVDAGRLIDHEDMVAWANSLGTDK
PLPPPVPRK

Download         Length: 270 bp

>AT57478 NZ_CP012945:4417468-4417737 [Devosia sp. A16]
ATGAGCACCCGAGTCCTGACGGCACATATTCCTGAGGAACTGGCGGAGAAAGTAGATCGCTACGCCGAATCCATGGAGCG
CTCTCGAGCCTGGATCGTCAAGCAGGCGCTTTCCAACTGGGTAGATTGGGAAGAAGAGAAGCTTCGGCGTACCTTGGAGG
GGCTTGCGGACGTCGACGCTGGCCGTCTCATCGATCATGAGGACATGGTGGCGTGGGCAAATAGCCTCGGCACGGACAAG
CCACTCCCTCCACCAGTCCCGCGCAAGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References