Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/PIN-MazE
Location 2011429..2012056 Replicon chromosome
Accession NZ_CP012945
Organism Devosia sp. A16

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag APS40_RS09795 Protein ID WP_055046869.1
Coordinates 2011429..2011833 (-) Length 135 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag APS40_RS09800 Protein ID WP_055046870.1
Coordinates 2011820..2012056 (-) Length 79 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
APS40_RS09765 2007163..2008098 - 936 WP_055046863.1 hydroxymethylbilane synthase -
APS40_RS09770 2008169..2009227 + 1059 WP_055046864.1 tRNA (adenosine(37)-N6)-threonylcarbamoyltransferase complex transferase subunit TsaD -
APS40_RS09775 2009217..2010185 + 969 WP_055046865.1 NAD(P)H-dependent glycerol-3-phosphate dehydrogenase -
APS40_RS09780 2010185..2010478 + 294 WP_055046866.1 hypothetical protein -
APS40_RS09785 2010481..2010906 + 426 WP_055046867.1 EVE domain-containing protein -
APS40_RS09790 2011009..2011428 + 420 WP_055046868.1 DUF1761 domain-containing protein -
APS40_RS09795 2011429..2011833 - 405 WP_055046869.1 PIN domain-containing protein Toxin
APS40_RS09800 2011820..2012056 - 237 WP_055046870.1 AbrB/MazE/SpoVT family DNA-binding domain-containing protein Antitoxin
APS40_RS09805 2012112..2012303 - 192 WP_055046871.1 DUF1674 domain-containing protein -
APS40_RS09810 2012400..2013386 + 987 WP_055046872.1 zinc metalloprotease HtpX -
APS40_RS09815 2013392..2014690 + 1299 WP_055046873.1 RsmB/NOP family class I SAM-dependent RNA methyltransferase -
APS40_RS09820 2014770..2016404 + 1635 WP_055046874.1 heparinase II/III family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(6-115)

Antitoxin

SpoVT-AbrB domain

(5-37)


Sequences

Toxin        


Download         Length: 135 a.a.        Molecular weight: 14726.86 Da        Isoelectric Point: 4.6805

>T57477 WP_055046869.1 NZ_CP012945:c2011833-2011429 [Devosia sp. A16]
MPGVSFLDTNILVYFAVQDPARFGRAAEIVEAGGTISVQVLNEFANVARSKMHMEWGEISEVEDLLCSLLQVHPLTVETH
RQALALAERHAFQVYDATILASALEAACTTLYAEDMQHGQLIAGRLRIVNPFVS

Download         Length: 405 bp

>T57477 NZ_CP012945:c2011833-2011429 [Devosia sp. A16]
ATGCCAGGCGTTAGCTTCCTCGACACCAACATCCTCGTCTACTTCGCAGTTCAGGACCCGGCGCGTTTTGGCCGGGCTGC
CGAGATTGTGGAGGCAGGCGGGACGATCAGCGTTCAGGTGCTCAACGAGTTCGCGAACGTCGCTCGCTCGAAGATGCACA
TGGAGTGGGGCGAAATTTCCGAGGTGGAGGACTTGCTCTGCAGCCTGCTGCAGGTGCACCCGCTAACCGTGGAGACGCAC
CGACAGGCGCTGGCCCTCGCGGAGCGCCATGCTTTCCAAGTTTACGACGCGACGATCCTCGCATCGGCCCTCGAGGCTGC
CTGCACCACCCTCTATGCCGAAGACATGCAGCACGGCCAGCTGATCGCTGGCCGGCTGCGGATCGTCAACCCGTTCGTCA
GTTAG

Antitoxin


Download         Length: 79 a.a.        Molecular weight: 9036.31 Da        Isoelectric Point: 10.4352

>AT57477 WP_055046870.1 NZ_CP012945:c2012056-2011820 [Devosia sp. A16]
MKVSKWGNSLAVRIPTDVASRLGLKEGDEVDLQPSETNGIELLRLASRRERIERLRELMKGRLPADYRFDREEANARR

Download         Length: 237 bp

>AT57477 NZ_CP012945:c2012056-2011820 [Devosia sp. A16]
ATGAAGGTCTCGAAATGGGGAAACAGCCTCGCGGTACGCATCCCAACGGACGTGGCCAGCAGACTCGGCCTGAAGGAGGG
TGACGAGGTTGACCTTCAGCCCTCCGAAACCAACGGGATCGAACTGCTCCGCCTTGCCTCGCGCCGCGAACGCATCGAAC
GGCTGAGGGAGTTGATGAAAGGGCGGCTGCCGGCGGACTACCGGTTTGATCGCGAAGAAGCGAATGCCAGGCGTTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References