Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) parDE/CC2985(antitoxin)
Location 1228979..1229525 Replicon chromosome
Accession NZ_CP012945
Organism Devosia sp. A16

Toxin (Protein)


Gene name parE Uniprot ID -
Locus tag APS40_RS05945 Protein ID WP_156342844.1
Coordinates 1228979..1229275 (-) Length 99 a.a.

Antitoxin (Protein)


Gene name parD Uniprot ID -
Locus tag APS40_RS05950 Protein ID WP_055046181.1
Coordinates 1229262..1229525 (-) Length 88 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
APS40_RS05930 1224553..1225149 - 597 WP_055046177.1 5-formyltetrahydrofolate cyclo-ligase -
APS40_RS05935 1225574..1227274 + 1701 WP_055046178.1 cation:proton antiporter -
APS40_RS05940 1227365..1228966 + 1602 WP_055046179.1 GGDEF domain-containing protein -
APS40_RS05945 1228979..1229275 - 297 WP_156342844.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
APS40_RS05950 1229262..1229525 - 264 WP_055046181.1 type II toxin-antitoxin system ParD family antitoxin Antitoxin
APS40_RS05955 1229663..1230550 + 888 WP_197279446.1 lytic transglycosylase domain-containing protein -
APS40_RS05960 1230547..1230924 - 378 WP_055046183.1 cell division protein ZapA -
APS40_RS05965 1230930..1231229 - 300 WP_055046184.1 DUF4164 family protein -
APS40_RS05970 1231423..1233402 + 1980 WP_055046185.1 transketolase -
APS40_RS05975 1233446..1234453 + 1008 WP_055046186.1 type I glyceraldehyde-3-phosphate dehydrogenase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(4-92)

Antitoxin

Antitoxin ParD

(3-70)


Sequences

Toxin        


Download         Length: 99 a.a.        Molecular weight: 11320.94 Da        Isoelectric Point: 5.5057

>T57476 WP_156342844.1 NZ_CP012945:c1229275-1228979 [Devosia sp. A16]
VMRLRLTPDAEQDITDIFVYGVLTYGLKLSEEYSGRLQGAIDRLGDYPMLGREHDEINPPVRLYRYESHHILYAIRDGEL
LVLRVLHGSVDWISLLGH

Download         Length: 297 bp

>T57476 NZ_CP012945:c1229275-1228979 [Devosia sp. A16]
GTGATGCGGCTTAGGCTGACGCCGGACGCAGAACAGGACATCACCGACATTTTCGTCTACGGGGTGCTCACTTACGGGCT
GAAGCTCAGTGAGGAGTACAGTGGACGGCTGCAAGGCGCTATCGACCGCCTCGGGGACTATCCAATGCTTGGTCGAGAGC
ACGACGAGATCAACCCGCCGGTACGCCTCTACCGGTATGAGTCGCACCATATCCTTTATGCGATCCGCGACGGCGAACTA
CTCGTGCTGCGCGTGCTGCACGGCAGTGTCGACTGGATCAGCCTGCTTGGTCACTGA

Antitoxin


Download         Length: 88 a.a.        Molecular weight: 9685.95 Da        Isoelectric Point: 5.1467

>AT57476 WP_055046181.1 NZ_CP012945:c1229525-1229262 [Devosia sp. A16]
MATMNISLPDKMKQWVEEQTADGRYANASDYVRDLVRRDQARREAISKLQQVVDDALASGISDKSIEEVFAEARVKAMAA
LKARDAA

Download         Length: 264 bp

>AT57476 NZ_CP012945:c1229525-1229262 [Devosia sp. A16]
ATGGCTACCATGAACATCTCGCTGCCCGACAAGATGAAACAATGGGTTGAGGAGCAGACCGCCGACGGTCGCTACGCCAA
CGCCAGCGACTACGTGCGCGACCTGGTGCGGCGCGATCAGGCTCGGCGCGAGGCTATCAGCAAGCTGCAGCAAGTCGTCG
ACGATGCGCTGGCCAGTGGCATCAGTGACAAATCGATCGAGGAGGTTTTTGCCGAAGCCAGGGTGAAAGCGATGGCGGCA
TTGAAGGCTCGTGATGCGGCTTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References