Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hipBA/HipA-couple_hipB
Location 1348131..1349748 Replicon plasmid unnamed
Accession NZ_CP012940
Organism Ralstonia solanacearum strain UW163

Toxin (Protein)


Gene name hipA Uniprot ID F6GA13
Locus tag UW163_RS21355 Protein ID WP_014619008.1
Coordinates 1348402..1349748 (+) Length 449 a.a.

Antitoxin (Protein)


Gene name hipB Uniprot ID -
Locus tag UW163_RS21350 Protein ID WP_042549221.1
Coordinates 1348131..1348397 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
UW163_RS21320 1343358..1343834 + 477 WP_003265832.1 RidA family protein -
UW163_RS21325 1343935..1344771 + 837 WP_014619014.1 AraC family transcriptional regulator -
UW163_RS21330 1344774..1345892 + 1119 WP_014619013.1 dienelactone hydrolase -
UW163_RS21335 1345931..1346314 - 384 WP_014619012.1 VOC family protein -
UW163_RS21340 1346571..1347005 + 435 WP_042549879.1 PGDYG domain-containing protein -
UW163_RS21345 1347021..1347872 - 852 WP_124994750.1 hypothetical protein -
UW163_RS21350 1348131..1348397 + 267 WP_042549221.1 helix-turn-helix domain-containing protein Antitoxin
UW163_RS21355 1348402..1349748 + 1347 WP_014619008.1 type II toxin-antitoxin system HipA family toxin Toxin
UW163_RS21360 1349843..1350739 + 897 WP_014619007.1 DUF2236 domain-containing protein -
UW163_RS21365 1350743..1352314 - 1572 WP_014619006.1 MFS transporter -
UW163_RS21370 1352407..1353357 - 951 WP_039552434.1 LysR family transcriptional regulator -
UW163_RS21375 1353496..1354122 + 627 WP_014619003.1 FMN-dependent NADH-azoreductase -
UW163_RS26585 1354270..1354416 - 147 WP_014619002.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - cheY / flgG / fliM / fliI / acrB / adeG / cheY / cheB / cheW / motA / cyaB 1..1932001 1932001


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA-like, C-terminal

(159-413)

Antitoxin

Cro/C1-type helix-turn-helix domain

(17-67)


Sequences

Toxin        


Download         Length: 449 a.a.        Molecular weight: 49543.83 Da        Isoelectric Point: 7.8550

>T57468 WP_014619008.1 NZ_CP012940:1348402-1349748 [Ralstonia solanacearum]
MGRRSHTRALGLWMNGTHVGRWELHPHQGDVLKYAASWVAAPEGRPLSLSLPFTPDNAPHKGPAVRAYFENLLPDSRDIR
ERIARRFQAGTTEAFDLLEQIGRDCIGALQVLPADMAPPATGDIDAEPLTEAQIAQTLRETVAPPPLGGMPEDDSHFRIS
IAGAQEKTAFLQIDGHWYRPRGATPTSHIFKLPMGLVGNMKLDLSDSVENEWLCALVLRAYGLPVAHCRPLVFEDQKVLA
VERFDRMWWDRGGKRLLRLPQEDMCQATATPPHLKYEADGGPGIDRIMGLLDGSAHREADRLTLFRSQVLFWMLCAPDGH
AKNFSLALRPGGAYALTPLYDVMSAYPLLGEGPGKLSPHRIRLAMAVRSKNAHWKMQDIQRRHWLGLGQRYGIVTSDGAD
AASIVDNLVARTPEVARTVRALLPEGFPQPLADRILQGLRHAADKLAG

Download         Length: 1347 bp

>T57468 NZ_CP012940:1348402-1349748 [Ralstonia solanacearum]
ATGGGGCGCCGGTCGCATACGCGGGCCCTCGGGCTCTGGATGAATGGCACCCATGTCGGCCGCTGGGAGCTGCACCCGCA
CCAGGGCGACGTGCTGAAGTACGCGGCATCCTGGGTGGCCGCGCCCGAGGGTCGGCCCCTGTCGCTGTCCCTGCCGTTCA
CGCCGGACAACGCGCCCCACAAGGGCCCGGCGGTCCGGGCGTATTTCGAGAACCTCCTGCCGGACAGCCGCGACATCCGC
GAGCGCATCGCGCGCCGTTTCCAGGCCGGGACAACCGAGGCGTTCGACCTGCTGGAGCAGATCGGCCGCGACTGCATCGG
CGCCCTGCAAGTGCTGCCGGCCGACATGGCCCCACCGGCCACGGGCGACATCGACGCGGAACCGCTGACCGAGGCGCAGA
TCGCGCAGACGCTGCGGGAGACCGTCGCCCCGCCCCCCTTGGGCGGCATGCCGGAAGACGATAGCCATTTCCGCATCTCG
ATCGCCGGCGCGCAGGAAAAGACGGCCTTCCTCCAGATCGACGGACACTGGTACCGCCCCCGGGGCGCGACGCCAACCAG
CCACATCTTCAAGCTGCCGATGGGGCTGGTCGGCAACATGAAGCTGGACCTGAGCGATTCGGTGGAAAACGAATGGCTGT
GCGCCCTGGTGCTGCGGGCGTATGGCCTGCCCGTCGCGCACTGCCGGCCGCTGGTGTTCGAAGACCAGAAGGTGCTCGCC
GTGGAGCGGTTCGACCGCATGTGGTGGGACCGCGGCGGCAAACGGCTCCTCCGCCTGCCGCAGGAAGACATGTGCCAGGC
CACGGCGACGCCCCCGCACCTGAAGTACGAGGCCGACGGCGGCCCCGGCATCGACCGCATCATGGGCCTGCTCGACGGCT
CCGCGCACCGGGAGGCCGACCGCCTGACGCTGTTCCGCAGCCAGGTGCTGTTCTGGATGCTGTGTGCGCCCGATGGCCAC
GCGAAGAACTTCAGCCTCGCGCTACGTCCCGGCGGCGCCTACGCGCTCACGCCGCTGTACGACGTGATGTCGGCCTACCC
GCTGCTGGGCGAGGGGCCGGGCAAGCTGTCGCCGCACCGGATCCGGCTGGCGATGGCCGTCCGCTCGAAGAATGCGCACT
GGAAAATGCAGGACATCCAGCGTCGCCACTGGCTGGGCCTGGGCCAACGCTACGGCATCGTCACGTCCGATGGCGCGGAT
GCCGCCTCCATCGTGGACAACCTGGTGGCCCGGACGCCCGAGGTGGCCCGTACCGTGCGCGCGCTGCTGCCGGAAGGCTT
CCCGCAGCCGCTGGCCGACCGCATTCTGCAGGGGCTGCGGCACGCTGCGGACAAACTCGCGGGATAG

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 9636.14 Da        Isoelectric Point: 10.9487

>AT57468 WP_042549221.1 NZ_CP012940:1348131-1348397 [Ralstonia solanacearum]
MNEFIVRTPEQLPAILKGFRKQAGLSQAELAARMGVRQQTLSALERNAENVSAGRLMRLLSVLGVELVLRKPDAAGEPGR
PASDQPQW

Download         Length: 267 bp

>AT57468 NZ_CP012940:1348131-1348397 [Ralstonia solanacearum]
ATGAACGAGTTCATCGTACGCACCCCCGAGCAGTTGCCGGCGATCCTCAAGGGCTTCCGTAAACAGGCCGGGCTGAGCCA
GGCCGAACTGGCCGCCCGGATGGGCGTGCGCCAGCAAACCCTCTCAGCGCTGGAGCGCAACGCAGAAAACGTGAGCGCCG
GGCGGCTGATGCGCCTGCTGTCGGTGCTGGGCGTGGAGCTGGTGCTGCGCAAACCCGACGCCGCCGGCGAGCCCGGCCGC
CCGGCGTCCGACCAGCCGCAGTGGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB F6GA13

Antitoxin

Source ID Structure

References