Detailed information of TA system TA057465

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vapBC/LOTUS_5_Limkain_b1-Phd
• Location: 1145946..1146607
• Replicon: chromosome
• Accession: NZ_CP012939
• Organism: Ralstonia solanacearum strain UW163

Toxin (Protein)

• Gene name: vapC
• Uniprot ID: A0A399W071
• Locus tag: UW163_RS05420
• Protein ID: WP_003278076.1
• Coordinates: 1145946..1146359 (-)
• Length: 138 a.a.

Antitoxin (Protein)

• Gene name: vapB
• Uniprot ID: -
• Locus tag: UW163_RS05425
• Protein ID: WP_003278075.1
• Coordinates: 1146356..1146607 (-)
• Length: 84 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
UW163_RS05380	1140949..1141395	+	447	WP_014617601.1	hypothetical protein	-
UW163_RS05385	1141503..1142276	+	774	WP_014617600.1	hypothetical protein	-
UW163_RS05390	1142285..1142677	+	393	WP_014617599.1	hypothetical protein	-
UW163_RS05395	1142674..1142895	+	222	WP_014617598.1	hypothetical protein	-
UW163_RS05400	1142870..1143514	+	645	WP_014617597.1	hypothetical protein	-
UW163_RS05405	1143557..1143847	-	291	WP_014617596.1	H-NS histone family protein	-
UW163_RS05410	1144042..1145508	-	1467	WP_014617595.1	YOPP/AvrRxv family protein	-
UW163_RS05415	1145708..1145941	+	234	WP_124994719.1	hypothetical protein	-
UW163_RS05420	1145946..1146359	-	414	WP_003278076.1	type II toxin-antitoxin system VapC family toxin	Toxin
UW163_RS05425	1146356..1146607	-	252	WP_003278075.1	type II toxin-antitoxin system Phd/YefM family antitoxin	Antitoxin
UW163_RS05430	1146680..1150780	+	4101	WP_042567785.1	phage tail tape measure protein	-
UW163_RS05435	1150784..1151179	+	396	WP_061581058.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	-	1115485..1166174	50689

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• PIN domain (3-122)

Antitoxin

• Type II toxin-antitoxin system, antitoxin Phd/YefM (1-63)

Sequences

Toxin

Protein

• Length: 138 a.a.
• Molecular weight: 15756.12 Da
• Isoelectric Point: 6.2337

>T57465 WP_003278076.1 NZ_CP012939:c1146359-1145946 [Ralstonia solanacearum]
MSYLIDTNVLSELRRKQPDARVLAWMQDRPRQSLYLSVLTLGEIRKGIERLDDAARRQHLIDWLETELPNYFLGRLLDID
AHTADRWGRLMSSANRPLPAIDGLLAATALQHDLILVTRNTKDFVGLDVPLINPWET

Nucleotide

• Length: 414 bp

>T57465 NZ_CP012939:c1146359-1145946 [Ralstonia solanacearum]
TTGAGTTACCTGATCGACACCAATGTGCTGTCCGAACTACGCCGCAAGCAGCCCGATGCGCGCGTGCTCGCCTGGATGCA
AGACCGGCCGCGCCAGTCGCTCTACCTGAGCGTGCTGACCCTGGGCGAAATCCGCAAAGGGATCGAGCGGCTGGACGACG
CAGCACGCCGCCAGCACCTGATCGACTGGCTCGAAACGGAACTGCCGAACTACTTCCTCGGCCGCTTGCTCGACATCGAT
GCCCATACCGCCGACCGCTGGGGCCGGCTGATGTCGAGCGCCAACCGGCCGCTGCCGGCCATCGACGGCCTGCTCGCCGC
GACCGCCCTGCAGCACGACCTCATACTGGTCACGCGTAACACGAAGGATTTCGTCGGACTCGACGTCCCGCTCATCAACC
CGTGGGAAACGTGA

Antitoxin

Protein

• Length: 84 a.a.
• Molecular weight: 9242.46 Da
• Isoelectric Point: 5.0774

>AT57465 WP_003278075.1 NZ_CP012939:c1146607-1146356 [Ralstonia solanacearum]
MQSWQLQAAKARFSDVVKRAADDGPQEITVHGRPVAVVISRALFDRLSGGGESLVDFMRQSPLAGLDDVVFERERSLPRE
VEF

Nucleotide

• Length: 252 bp

>AT57465 NZ_CP012939:c1146607-1146356 [Ralstonia solanacearum]
ATGCAAAGCTGGCAGTTGCAAGCCGCCAAGGCGCGGTTTTCCGACGTCGTGAAGCGCGCAGCGGACGATGGTCCGCAGGA
AATCACGGTGCATGGCCGCCCGGTCGCGGTTGTGATCTCGCGCGCACTGTTCGATCGCCTGAGTGGCGGCGGGGAGTCGC
TGGTCGACTTCATGCGCCAGTCTCCGTTGGCGGGCCTGGACGACGTCGTCTTCGAGCGCGAACGCAGCCTGCCGCGCGAG
GTCGAGTTTTGA

Structures

Toxin

• AlphaFold DB: A0A399W071