Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) parDE/RelE-RHH
Location 2395..2942 Replicon plasmid p12-4374_96
Accession NZ_CP012929
Organism Salmonella enterica subsp. enterica serovar Heidelberg strain 12-4374

Toxin (Protein)


Gene name parE Uniprot ID W0LWB3
Locus tag APS45_RS23835 Protein ID WP_000970007.1
Coordinates 2661..2942 (+) Length 94 a.a.

Antitoxin (Protein)


Gene name parD Uniprot ID E1QMW3
Locus tag APS45_RS23830 Protein ID WP_000079941.1
Coordinates 2395..2664 (+) Length 90 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
APS45_RS23825 455..1486 + 1032 WP_000907873.1 replication initiation protein -
APS45_RS23830 2395..2664 + 270 WP_000079941.1 hypothetical protein Antitoxin
APS45_RS23835 2661..2942 + 282 WP_000970007.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
APS45_RS23840 2982..3830 + 849 WP_001057991.1 3'-5' exonuclease -
APS45_RS23845 3947..4420 + 474 WP_001334658.1 hypothetical protein -
APS45_RS27020 4897..5163 - 267 WP_000955263.1 hypothetical protein -
APS45_RS23855 5163..5657 - 495 WP_001459505.1 hypothetical protein -
APS45_RS23860 5713..6315 - 603 WP_000517695.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - - 1..96042 96042


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(1-120)

Antitoxin

Ribbon-helix-helix protein, CopG

(4-39)


Sequences

Toxin        


Download         Length: 94 a.a.        Molecular weight: 12066.38 Da        Isoelectric Point: 12.7685

>T57461 WP_000970007.1 NZ_CP012929:2661-2942 [Salmonella enterica subsp. enterica serovar Heidelberg]
KKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKK
KKKKKKKKKKKKKK

Download         Length: 282 bp

>T57461 NZ_CP012929:2661-2942 [Salmonella enterica subsp. enterica serovar Heidelberg]
AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA
AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA
AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA
AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA

Antitoxin


Download         Length: 90 a.a.        Molecular weight: 11553.68 Da        Isoelectric Point: 12.7493

>AT57461 WP_000079941.1 NZ_CP012929:2395-2664 [Salmonella enterica subsp. enterica serovar Heidelberg]
KKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKK
KKKKKKKKKK

Download         Length: 270 bp

>AT57461 NZ_CP012929:2395-2664 [Salmonella enterica subsp. enterica serovar Heidelberg]
AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA
AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA
AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA
AAAAAAAAAAAAAAAAAAAAAAAAAAAAAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7G1GDN5

Antitoxin

Source ID Structure
AlphaFold DB A0A629TXC5

References