Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) ccdAB/CcdA(antitoxin)
Location 19937..20462 Replicon plasmid pSA02DT10168701_99
Accession NZ_CP012923
Organism Salmonella enterica subsp. enterica serovar Heidelberg strain SA02DT10168701

Toxin (Protein)


Gene name ccdB Uniprot ID S1PFV8
Locus tag APS46_RS23280 Protein ID WP_001159871.1
Coordinates 20157..20462 (+) Length 102 a.a.

Antitoxin (Protein)


Gene name ccdA Uniprot ID H9TJP1
Locus tag APS46_RS23275 Protein ID WP_000813630.1
Coordinates 19937..20155 (+) Length 73 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
APS46_RS23245 14938..15528 - 591 WP_000194550.1 hypothetical protein -
APS46_RS23250 15528..15782 - 255 WP_000343103.1 hypothetical protein -
APS46_RS23255 16134..17135 + 1002 WP_000774875.1 DUF4238 domain-containing protein -
APS46_RS23260 17311..17655 - 345 WP_000793307.1 hypothetical protein -
APS46_RS23265 18154..18408 - 255 WP_000678527.1 hypothetical protein -
APS46_RS23270 18453..19379 - 927 WP_001290416.1 hypothetical protein -
APS46_RS23275 19937..20155 + 219 WP_000813630.1 type II toxin-antitoxin system antitoxin CcdA Antitoxin
APS46_RS23280 20157..20462 + 306 WP_001159871.1 type II toxin-antitoxin system toxin CcdB Toxin
APS46_RS23285 20463..21269 + 807 WP_000016969.1 site-specific integrase -
APS46_RS23290 21449..22093 + 645 WP_001144036.1 ParA family protein -
APS46_RS23295 22180..22488 + 309 WP_000030199.1 hypothetical protein -
APS46_RS23300 22902..23882 + 981 WP_000688514.1 plasmid segregation protein ParM -
APS46_RS23305 23875..24291 + 417 WP_001278818.1 plasmid partitioning/stability family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - - 1..99011 99011


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(12-128)

Antitoxin

Post-segregation antitoxin CcdA

(19-61)


Sequences

Toxin        


Download         Length: 102 a.a.        Molecular weight: 13091.77 Da        Isoelectric Point: 12.8043

>T57460 WP_001159871.1 NZ_CP012923:20157-20462 [Salmonella enterica subsp. enterica serovar Heidelberg]
KKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKK
KKKKKKKKKKKKKKKKKKKKKK

Download         Length: 306 bp

>T57460 NZ_CP012923:20157-20462 [Salmonella enterica subsp. enterica serovar Heidelberg]
AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA
AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA
AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA
AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA

Antitoxin


Download         Length: 73 a.a.        Molecular weight: 9374.72 Da        Isoelectric Point: 12.6573

>AT57460 WP_000813630.1 NZ_CP012923:19937-20155 [Salmonella enterica subsp. enterica serovar Heidelberg]
KKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKK

Download         Length: 219 bp

>AT57460 NZ_CP012923:19937-20155 [Salmonella enterica subsp. enterica serovar Heidelberg]
AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA
AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA
AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A829CCE8

Antitoxin

Source ID Structure
AlphaFold DB A0A829CEF5

References