Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) omega-epsilon-zeta/zeta-epsilon
Location 1303159..1304710 Replicon chromosome
Accession NZ_CP012911
Organism Streptococcus suis strain NSUI060

Toxin (Protein)


Gene name zeta Uniprot ID -
Locus tag APQ97_RS11915 Protein ID WP_079739431.1
Coordinates 1303159..1304436 (-) Length 426 a.a.

Antitoxin (Protein)


Gene name epsilon Uniprot ID R2XCR7
Locus tag APQ97_RS06390 Protein ID WP_000301765.1
Coordinates 1304438..1304710 (-) Length 91 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
APQ97_RS06365 1298247..1300058 - 1812 WP_014637055.1 glutamine--fructose-6-phosphate transaminase (isomerizing) -
APQ97_RS06370 1300490..1301839 - 1350 WP_053866436.1 ISLre2 family transposase -
APQ97_RS06375 1302013..1302228 - 216 WP_053866437.1 hypothetical protein -
APQ97_RS06380 1302275..1303072 - 798 WP_053866438.1 AAA family ATPase -
APQ97_RS11915 1303159..1304436 - 1278 WP_079739431.1 zeta toxin family protein Toxin
APQ97_RS06390 1304438..1304710 - 273 WP_000301765.1 antitoxin Antitoxin
APQ97_RS06395 1304727..1304936 - 210 WP_000527318.1 peptide-binding protein -
APQ97_RS06400 1305035..1305931 - 897 WP_002334978.1 ParA family protein -
APQ97_RS11920 1306020..1306304 - 285 WP_074390291.1 topoisomerase DNA-binding C4 zinc finger domain-containing protein -
APQ97_RS06405 1306450..1307187 - 738 WP_012477196.1 23S rRNA (adenine(2058)-N(6))-methyltransferase Erm(B) -
APQ97_RS06410 1307312..1307407 - 96 WP_001809736.1 23S rRNA methyltransferase attenuation leader peptide -
APQ97_RS06415 1307483..1307824 - 342 Protein_1232 recombinase family protein -
APQ97_RS06420 1308176..1308493 - 318 WP_053866439.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Integrative and Conjugative Element erm(B) - 1300490..1331209 30719
- flank IS/Tn erm(B) - 1306450..1311197 4747


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Zeta toxin domain

(27-214)

Antitoxin

Bacterial epsilon antitoxin

(2-90)


Sequences

Toxin        


Download         Length: 426 a.a.        Molecular weight: 48802.57 Da        Isoelectric Point: 9.0764

>T57457 WP_079739431.1 NZ_CP012911:c1304436-1303159 [Streptococcus suis]
MANIVNFTDKQFENRLNDNLEELIQGKKAVESPTAFLLGGQPGSGKTSLRSAIFEETQGNVIVIDNDTFKQQHPNFDELV
KLYEKDVVKHVTPYSNRMTEAIISRLSDQGYNLVIEGTGRTTDVPIQTATMLQSKGYETKIYVMAVPKIESYLGTIERYE
TMYADDPMTARATPKQAHDIVVKNLPTNLETLHKTGLFSDIRLYNREGVKLYSSLETPSISPKETLERELNRKVSGKEIQ
PTLERIEQKMVQNQHQETPEFKAIQQKANKDRPQLQAMLAYIREGDIVVVTELERLGRNNKELTEVMNDIQAKGATLEVL
NLPTLRGIEDDNLRRLLNNLILELYKYQAQAERERIKERQRQGIAIAKTQGKYKGRKAIFSEDDSRLLHAFDLYLEGLSD
KDVAKLTGINERTFRRYREKHKIKR

Download         Length: 1278 bp

>T57457 NZ_CP012911:c1304436-1303159 [Streptococcus suis]
ATGGCAAATATAGTCAATTTTACTGACAAACAATTTGAGAATCGCTTAAATGATAATTTAGAAGAATTGATTCAAGGAAA
AAAAGCGGTTGAATCGCCAACCGCTTTTTTACTTGGTGGGCAACCAGGGTCAGGGAAAACCAGTTTGCGATCAGCAATTT
TTGAAGAAACACAAGGGAATGTTATTGTCATTGATAATGATACCTTTAAACAACAGCACCCTAATTTTGATGAACTAGTG
AAGCTTTATGAAAAAGACGTAGTAAAACACGTTACCCCTTATTCTAATCGCATGACAGAAGCGATCATAAGCCGTTTGAG
CGATCAAGGGTATAATTTGGTGATCGAAGGTACAGGACGAACAACAGACGTTCCTATTCAAACCGCAACAATGCTTCAAT
CTAAAGGTTATGAAACAAAAATATACGTCATGGCAGTACCGAAAATTGAATCATACTTAGGAACAATTGAACGATATGAA
ACCATGTATGCAGATGATCCAATGACAGCCAGGGCAACACCAAAACAAGCGCATGATATTGTTGTCAAAAACTTACCGAC
CAATTTAGAAACCCTTCATAAAACGGGCTTATTTAGCGATATAAGGCTTTACAATAGAGAAGGAGTGAAACTCTATTCAA
GCTTAGAAACGCCTTCCATTAGTCCGAAAGAGACCTTAGAAAGAGAATTAAATCGTAAAGTATCAGGGAAAGAAATTCAA
CCGACTTTGGAGAGAATAGAGCAAAAAATGGTTCAAAATCAACACCAAGAAACCCCTGAATTTAAAGCAATTCAACAAAA
AGCTAATAAAGACCGCCCTCAGTTACAAGCTATGCTTGCTTATATACGTGAAGGTGATATAGTGGTTGTGACAGAATTAG
AACGCCTGGGTAGGAATAACAAGGAGCTAACTGAGGTCATGAATGATATTCAAGCCAAGGGGGCAACCTTGGAAGTCTTA
AATCTTCCCACTCTTCGAGGGATTGAGGATGACAACCTGAGACGGCTCTTGAACAATCTTATCCTGGAACTCTACAAGTA
CCAGGCACAAGCTGAAAGGGAACGCATAAAGGAACGGCAACGCCAAGGGATAGCTATTGCCAAGACTCAAGGAAAGTACA
AAGGCAGAAAAGCCATTTTTTCAGAAGATGACAGCAGGCTTCTTCATGCCTTTGACCTTTACCTTGAAGGTCTATCAGAT
AAAGACGTTGCCAAGCTAACAGGTATCAACGAACGTACTTTTAGGCGGTATCGTGAAAAGCATAAGATAAAAAGATAA

Antitoxin


Download         Length: 91 a.a.        Molecular weight: 10721.25 Da        Isoelectric Point: 6.4676

>AT57457 WP_000301765.1 NZ_CP012911:c1304710-1304438 [Streptococcus suis]
MAVTYEKTFEIEIINELSASVYNRVLNYVLNHELNKNDSQLLEVNLLNQLKLAKRVNLFDYSLEELQAVHEYWRSMNRYS
KQVLNKEKVA

Download         Length: 273 bp

>AT57457 NZ_CP012911:c1304710-1304438 [Streptococcus suis]
ATGGCAGTTACGTATGAAAAAACATTTGAAATAGAGATCATTAACGAATTATCGGCAAGCGTTTATAATCGAGTATTAAA
CTATGTTTTGAACCATGAATTAAATAAAAATGACTCTCAATTATTGGAAGTCAATTTATTAAACCAATTAAAGCTTGCAA
AACGTGTAAATCTTTTTGATTATTCTTTAGAAGAATTACAAGCCGTTCATGAGTATTGGCGGTCAATGAATCGTTACTCA
AAACAAGTTTTGAATAAAGAGAAAGTGGCTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
PDB 3Q8X
PDB 1GVN
AlphaFold DB A0A829F0A3

References