Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) abiEi-abiEii/AbiEii-AbiEi
Location 1014063..1015495 Replicon chromosome
Accession NZ_CP012911
Organism Streptococcus suis strain NSUI060

Toxin (Protein)


Gene name abiEi Uniprot ID A0A126UMF2
Locus tag APQ97_RS04940 Protein ID WP_024383472.1
Coordinates 1014650..1015495 (+) Length 282 a.a.

Antitoxin (Protein)


Gene name abiEii Uniprot ID A0A126UN77
Locus tag APQ97_RS04935 Protein ID WP_024401254.1
Coordinates 1014063..1014653 (+) Length 197 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
APQ97_RS04935 1014063..1014653 + 591 WP_024401254.1 type IV toxin-antitoxin system AbiEi family antitoxin domain-containing protein Antitoxin
APQ97_RS04940 1014650..1015495 + 846 WP_024383472.1 nucleotidyl transferase AbiEii/AbiGii toxin family protein Toxin
APQ97_RS04945 1015557..1018358 - 2802 WP_061286116.1 CHAP domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Integrative and Conjugative Element tet(O) - 968950..1026249 57299


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Nucleotidyl transferase AbiEii toxin, Type IV TA system

(33-258)

Antitoxin

Transcriptional regulator, AbiEi antitoxin

(6-50)


Sequences

Toxin        


Download         Length: 282 a.a.        Molecular weight: 32435.11 Da        Isoelectric Point: 5.7531

>T57456 WP_024383472.1 NZ_CP012911:1014650-1015495 [Streptococcus suis]
MNKAKLTALCHKISKNTGLTFNSVMTYYFLEVILKKLSQSTYSNHYIFKGGFLLSNVIGVESRSTVDIDFLFHQITLSED
TVKQQLKEILADSKEGISFTIQSITAIKESDDYGGYRATILCQIENIKQVIHLDIATGDVVTPQPITYDYKAIFDEDNFP
IIAYTIETILAEKLQTIYSRNFLNSRSKDFYDVYILSKLKKEDIDFIQLKNACQRTFTYRETELDFAKIIELLERFKSDP
TQNQQWQNYSKKYSYTKGISLADVLDEMIRLITVLISINSD

Download         Length: 846 bp

>T57456 NZ_CP012911:1014650-1015495 [Streptococcus suis]
ATGAATAAAGCTAAGCTAACAGCACTCTGTCATAAAATATCAAAGAATACTGGATTAACCTTTAATTCCGTGATGACCTA
TTACTTTCTTGAAGTGATTTTGAAAAAATTAAGTCAGAGTACCTATTCAAATCACTATATATTCAAAGGAGGATTCCTAC
TGTCAAATGTTATCGGAGTTGAATCTCGTAGCACGGTTGATATTGATTTTTTGTTCCATCAAATAACACTTTCAGAAGAT
ACTGTGAAGCAGCAACTCAAGGAAATTTTAGCAGATTCAAAAGAAGGTATTTCTTTCACAATTCAATCTATCACAGCAAT
TAAAGAAAGTGATGACTATGGTGGCTATCGAGCAACCATTTTGTGCCAAATTGAGAATATTAAACAAGTTATCCATTTGG
ATATTGCGACAGGTGATGTTGTAACTCCTCAGCCGATTACATACGACTATAAAGCTATTTTTGATGAAGACAATTTTCCA
ATCATTGCTTATACAATTGAAACAATTCTAGCTGAGAAACTTCAAACCATCTATTCACGCAACTTCTTGAACAGTAGAAG
CAAAGATTTTTACGATGTTTATATTCTTTCAAAACTGAAGAAAGAAGACATTGACTTCATTCAGTTGAAAAATGCCTGTC
AGAGAACATTTACATATCGCGAAACAGAACTCGATTTTGCAAAGATTATTGAACTACTCGAGAGATTCAAATCTGATCCT
ACTCAGAATCAACAATGGCAAAATTATTCAAAAAAATATAGCTATACAAAAGGGATTTCACTTGCAGATGTTCTTGATGA
GATGATTCGTCTTATAACAGTACTCATTTCTATAAATTCTGATTAA

Antitoxin


Download         Length: 197 a.a.        Molecular weight: 23210.76 Da        Isoelectric Point: 7.3107

>AT57456 WP_024401254.1 NZ_CP012911:1014063-1014653 [Streptococcus suis]
MSKKEILLEFIENHNGIITYKDCKALKIPTIYLTRLEKEGILYRVEKGIFLTQNGDYDEYYFFQYRYPKAIFSYISALYL
QQFTDEIPQYFDVTIPRGYRFNTPPANLNIHSVSKEYSELGITLVKTPMGNEVSVYDLERIICDFVIHREKIDTELFVKT
LQHYGNYSKKNLTKLYEYATKMNTLDKVKQTLEVLV

Download         Length: 591 bp

>AT57456 NZ_CP012911:1014063-1014653 [Streptococcus suis]
ATGTCAAAAAAAGAGATTCTACTTGAATTTATAGAAAACCACAATGGCATTATCACCTATAAAGATTGTAAAGCTCTAAA
GATTCCAACAATATATTTGACAAGACTAGAAAAAGAAGGGATTCTATACCGCGTCGAAAAAGGAATTTTCCTAACCCAGA
ATGGAGACTACGACGAATACTACTTCTTTCAGTACCGTTATCCCAAGGCTATTTTCTCTTATATCTCAGCGCTTTACCTG
CAACAATTTACAGATGAAATTCCTCAATATTTTGACGTAACCATTCCTAGAGGCTACCGTTTTAATACTCCTCCAGCAAA
TCTGAACATTCATTCCGTTTCTAAGGAATATAGCGAACTGGGAATTACACTTGTAAAAACCCCTATGGGAAACGAGGTAA
GTGTGTATGATTTAGAACGTATTATCTGTGATTTTGTGATTCATCGAGAAAAAATAGATACTGAGCTTTTTGTCAAAACA
CTTCAACATTACGGAAACTATTCTAAAAAAAATCTTACAAAACTCTATGAATATGCGACAAAAATGAACACTTTGGACAA
GGTCAAACAAACTCTGGAGGTCCTAGTATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A126UMF2

Antitoxin

Source ID Structure
AlphaFold DB A0A126UN77

References