Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/RelE(toxin)
Location 956625..957111 Replicon chromosome
Accession NZ_CP012911
Organism Streptococcus suis strain NSUI060

Toxin (Protein)


Gene name relE Uniprot ID A0A0K2E5U8
Locus tag APQ97_RS04660 Protein ID WP_002935012.1
Coordinates 956625..956882 (-) Length 86 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID A0A0K2E5B0
Locus tag APQ97_RS04665 Protein ID WP_002935014.1
Coordinates 956872..957111 (-) Length 80 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
APQ97_RS04640 952259..953329 + 1071 WP_002935006.1 tyrosine recombinase XerS -
APQ97_RS04645 953399..954907 - 1509 WP_013730362.1 phosphoglucomutase -
APQ97_RS04650 954983..955924 - 942 WP_002935009.1 sensor histidine kinase -
APQ97_RS04655 955921..956586 - 666 WP_009909826.1 response regulator transcription factor -
APQ97_RS04660 956625..956882 - 258 WP_002935012.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
APQ97_RS04665 956872..957111 - 240 WP_002935014.1 hypothetical protein Antitoxin
APQ97_RS04670 957203..959173 - 1971 WP_002935016.1 FtsX-like permease family protein -
APQ97_RS04675 959174..959926 - 753 WP_002935019.1 ABC transporter ATP-binding protein -
APQ97_RS04680 959943..960326 - 384 WP_002935021.1 NisI/SpaI family lantibiotic immunity lipoprotein -
APQ97_RS12520 960339..960479 - 141 WP_002935023.1 hypothetical protein -
APQ97_RS04690 960578..961312 - 735 WP_002935025.1 beta-carotene 15,15'-monooxygenase -
APQ97_RS12525 961325..961462 - 138 WP_002935027.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-75)

Antitoxin

Protein of unknown function DUF6290

(1-74)


Sequences

Toxin        


Download         Length: 86 a.a.        Molecular weight: 9849.52 Da        Isoelectric Point: 10.7134

>T57454 WP_002935012.1 NZ_CP012911:c956882-956625 [Streptococcus suis]
MSYKVILSAKAQKQIRKMDKTAASLILRYLYKHIDGCDNPRQYGKALTANRSGQWRYRIGNYRVIVNIEDDKLIVTSIKM
RNGSI

Download         Length: 258 bp

>T57454 NZ_CP012911:c956882-956625 [Streptococcus suis]
TTGAGTTATAAGGTTATTTTGTCTGCTAAGGCCCAAAAGCAAATTCGAAAGATGGATAAAACCGCTGCAAGTTTGATTTT
GCGCTATCTCTACAAGCATATTGACGGTTGCGACAACCCTAGACAATACGGAAAAGCCTTGACTGCTAATCGTTCTGGCC
AATGGCGCTATCGTATCGGCAATTACAGGGTTATCGTTAATATTGAAGATGATAAATTGATTGTGACAAGCATAAAAATG
AGAAATGGAAGTATATAA

Antitoxin


Download         Length: 80 a.a.        Molecular weight: 8924.19 Da        Isoelectric Point: 3.9191

>AT57454 WP_002935014.1 NZ_CP012911:c957111-956872 [Streptococcus suis]
MAAITLKVSEQDKLFMQAMAKFEGVSLSELIRTKTLEALEDEYDARVADVAWAEYQADLANRIEPMTLEQMAEELGIEL

Download         Length: 240 bp

>AT57454 NZ_CP012911:c957111-956872 [Streptococcus suis]
ATGGCAGCTATTACATTGAAAGTTTCTGAGCAGGACAAGCTCTTTATGCAGGCTATGGCAAAGTTTGAAGGTGTCAGTTT
GTCAGAACTCATTCGGACTAAAACCCTTGAAGCCCTTGAAGACGAGTACGATGCGCGTGTGGCAGACGTTGCTTGGGCAG
AATACCAAGCAGACTTGGCGAATAGAATTGAGCCGATGACATTAGAACAAATGGCTGAGGAGTTGGGCATTGAGTTATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0K2E5U8

Antitoxin

Source ID Structure
AlphaFold DB A0A0K2E5B0

References