Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/RelE(toxin)
Location 711161..711647 Replicon chromosome
Accession NZ_CP012911
Organism Streptococcus suis strain NSUI060

Toxin (Protein)


Gene name relE Uniprot ID D5AGV2
Locus tag APQ97_RS03530 Protein ID WP_011922754.1
Coordinates 711378..711647 (+) Length 90 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID D5AGV1
Locus tag APQ97_RS03525 Protein ID WP_002938604.1
Coordinates 711161..711388 (+) Length 76 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
APQ97_RS03500 706493..707038 - 546 WP_002938614.1 NAD(P)H-dependent oxidoreductase -
APQ97_RS03505 707101..707550 - 450 WP_002938613.1 MarR family transcriptional regulator -
APQ97_RS03510 707853..708350 + 498 WP_002938611.1 DUF5590 domain-containing protein -
APQ97_RS03515 708347..709528 + 1182 WP_061286109.1 pyridoxal phosphate-dependent aminotransferase -
APQ97_RS03520 709543..710889 + 1347 WP_013730302.1 asparagine--tRNA ligase -
APQ97_RS03525 711161..711388 + 228 WP_002938604.1 hypothetical protein Antitoxin
APQ97_RS03530 711378..711647 + 270 WP_011922754.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
APQ97_RS03535 712053..713372 + 1320 WP_002937278.1 MATE family efflux transporter -
APQ97_RS03540 713556..713933 + 378 WP_002937263.1 RidA family protein -
APQ97_RS03545 713955..714842 + 888 WP_002937261.1 RNase adapter RapZ -
APQ97_RS03550 714839..715813 + 975 WP_002937257.1 YvcK family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(6-87)

Antitoxin

Protein of unknown function DUF6290

(1-71)


Sequences

Toxin        


Download         Length: 90 a.a.        Molecular weight: 10437.49 Da        Isoelectric Point: 10.3916

>T57453 WP_011922754.1 NZ_CP012911:711378-711647 [Streptococcus suis]
MAYKLVLSDDALKQLKKMDRHVGMMLAKDLKKRLDGLENPRQFGKALVGDYKGLWRYRVGNYRVICDIIDNKMVILALEI
GHRKEIYKK

Download         Length: 270 bp

>T57453 NZ_CP012911:711378-711647 [Streptococcus suis]
ATGGCTTATAAGCTTGTTCTCAGCGATGATGCTTTGAAGCAGTTGAAAAAAATGGACAGGCATGTGGGGATGATGCTTGC
TAAGGATTTGAAAAAACGTTTGGACGGTTTGGAGAATCCAAGACAATTTGGGAAGGCCTTGGTAGGAGACTATAAGGGGC
TGTGGCGGTATAGAGTGGGGAATTACCGTGTAATTTGTGATATTATTGATAACAAAATGGTCATCCTGGCCCTTGAAATC
GGGCACCGGAAAGAAATCTATAAAAAATGA

Antitoxin


Download         Length: 76 a.a.        Molecular weight: 8450.51 Da        Isoelectric Point: 4.1589

>AT57453 WP_002938604.1 NZ_CP012911:711161-711388 [Streptococcus suis]
MGIVSLRLNDAEEEIFRSYAIHTGKSLSELFKTALAEQIEDQLDYEIGIKALKKFQENPVTHSIDDVLAELEDGL

Download         Length: 228 bp

>AT57453 NZ_CP012911:711161-711388 [Streptococcus suis]
ATGGGAATTGTATCCTTGCGATTAAACGATGCAGAAGAAGAAATTTTCAGAAGCTATGCTATTCATACAGGAAAAAGCCT
GTCTGAGCTATTCAAAACTGCACTTGCTGAACAGATAGAAGACCAGTTGGACTATGAAATTGGTATCAAGGCTTTGAAGA
AATTCCAAGAAAATCCTGTTACACACTCGATTGATGATGTTCTTGCGGAGTTAGAAGATGGCTTATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A126UKS2

Antitoxin

Source ID Structure
AlphaFold DB A0A140EXF0

References