Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hipBA/HipA-couple_hipB
Location 168599..170148 Replicon plasmid 2
Accession NZ_CP012910
Organism Ketogulonicigenium vulgare strain Hbe602

Toxin (Protein)


Gene name hipA Uniprot ID -
Locus tag KVH_RS16040 Protein ID WP_014538165.1
Coordinates 168599..169897 (-) Length 433 a.a.

Antitoxin (Protein)


Gene name hipB Uniprot ID -
Locus tag KVH_RS16045 Protein ID WP_044008278.1
Coordinates 169897..170148 (-) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KVH_RS16030 165761..166636 + 876 WP_014538167.1 chemotaxis protein CheR -
KVH_RS16035 166629..168455 + 1827 WP_014538166.1 response regulator -
KVH_RS16040 168599..169897 - 1299 WP_014538165.1 type II toxin-antitoxin system HipA family toxin Toxin
KVH_RS16045 169897..170148 - 252 WP_044008278.1 helix-turn-helix domain-containing protein Antitoxin
KVH_RS16050 170455..172029 + 1575 WP_014538164.1 ABC transporter substrate-binding protein -
KVH_RS16055 172048..172998 + 951 WP_013385705.1 ABC transporter permease -
KVH_RS16060 173008..173859 + 852 WP_014538163.1 ABC transporter permease -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - - 1..242716 242716


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA, N-terminal subdomain 1

(10-109)

Antitoxin

Cro/C1-type helix-turn-helix domain

(12-54)


Sequences

Toxin        


Download         Length: 433 a.a.        Molecular weight: 46516.30 Da        Isoelectric Point: 7.7322

>T57451 WP_014538165.1 NZ_CP012910:c169897-168599 [Ketogulonicigenium vulgare]
MGRRRAYPPLDVYMNARLVGQFARQSGGAHLFTYAQSWLDWPGRLPISRALPLQGARHQGAAVIAVFDNLLPDHPQIRDR
LAARVGAGGADAFSLLAEIGRDCVGALQFLPAGEVPDAQGLQADPLSAAQIGALLSNLSAAPLGLDRTRDFRISVAGAQE
KTALLRQGDQWFAPRGATPTTHILKPAIGLLPSGVDLRNAPQNEHFCLRLLAGFGLRVADTQVADFNGLSTLVVTRFDRL
WTADGRLIRLPQEDCCQALGVPSSLKYQSDGGPGIREISALLQASDQPVQDRLDFFKANILFWLMGATDGHAKNFSLSMA
PGGRFRLAPLYDVISLQPALAAGQMQPGDMRLAMRMGASRYYRIGDITGRHILESGLDAGLSRVQVLAICAEIAESAAAA
FEAASDTVQDQEMIAAIRAGFDQRLPRLMTMT

Download         Length: 1299 bp

>T57451 NZ_CP012910:c169897-168599 [Ketogulonicigenium vulgare]
ATGGGACGTCGCCGGGCCTATCCGCCATTGGATGTCTATATGAACGCACGTCTTGTCGGGCAGTTTGCGCGGCAAAGCGG
GGGCGCGCATCTGTTCACCTATGCGCAAAGCTGGCTGGACTGGCCGGGCCGGCTGCCGATCTCGCGGGCGTTGCCATTGC
AGGGCGCACGCCATCAAGGCGCGGCGGTGATTGCGGTTTTTGACAACCTGCTGCCCGATCACCCGCAGATCCGCGACCGT
CTGGCGGCGCGGGTCGGGGCGGGCGGTGCGGATGCGTTCAGCCTGCTGGCCGAGATTGGGCGCGATTGCGTCGGCGCGCT
GCAATTTCTGCCAGCGGGCGAGGTGCCTGACGCGCAGGGGCTGCAGGCCGATCCGCTGAGCGCGGCGCAGATTGGCGCGC
TGCTATCGAACCTGAGCGCCGCGCCGCTGGGGCTGGACCGCACGCGGGACTTCCGCATTTCGGTCGCTGGGGCGCAGGAA
AAGACGGCGCTGCTGCGGCAGGGCGATCAGTGGTTCGCGCCGCGCGGGGCGACCCCTACGACCCATATCCTGAAACCCGC
GATCGGGCTGCTGCCCAGTGGGGTCGATCTGCGCAACGCCCCCCAGAACGAGCATTTCTGTCTGCGCCTGCTGGCCGGTT
TCGGTCTGCGCGTGGCTGACACGCAGGTTGCGGATTTCAATGGCCTCAGCACGCTGGTTGTCACCCGGTTTGACCGGCTG
TGGACGGCGGATGGGCGGTTGATCCGCCTGCCGCAAGAGGATTGCTGTCAGGCCCTCGGCGTGCCGTCCAGCCTGAAATA
TCAAAGCGATGGCGGCCCGGGCATCCGCGAGATCAGCGCGCTGTTGCAGGCCAGCGATCAGCCGGTGCAGGACCGGTTGG
ATTTTTTCAAGGCGAATATCCTGTTCTGGCTGATGGGCGCGACCGATGGCCATGCCAAGAATTTCAGCCTGTCCATGGCC
CCCGGCGGGCGGTTCCGGCTGGCACCGCTGTATGATGTGATCAGCCTGCAACCGGCGCTGGCGGCGGGGCAGATGCAGCC
CGGGGATATGCGCCTCGCGATGCGGATGGGGGCAAGCCGCTATTATCGCATAGGGGATATCACCGGCCGCCATATTCTGG
AAAGCGGGCTGGATGCCGGATTGTCGCGGGTGCAGGTCCTGGCGATTTGCGCTGAGATTGCCGAAAGCGCCGCCGCGGCC
TTTGAGGCGGCATCAGACACAGTGCAGGACCAGGAGATGATCGCGGCGATCCGCGCGGGGTTTGACCAGCGCTTGCCCAG
ACTGATGACAATGACCTGA

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9042.29 Da        Isoelectric Point: 5.6379

>AT57451 WP_044008278.1 NZ_CP012910:c170148-169897 [Ketogulonicigenium vulgare]
MDHIIRSPKDIGHVLRQARKAGGLSQADLAAKAGLWQRTVSTLETGAADARLETLFDLLAALDLELQVVPRSRTDPDSFA
DLF

Download         Length: 252 bp

>AT57451 NZ_CP012910:c170148-169897 [Ketogulonicigenium vulgare]
ATGGACCATATCATTCGCTCACCCAAAGATATCGGACATGTGCTGCGGCAGGCCCGCAAGGCAGGGGGGCTGTCGCAGGC
TGACCTTGCCGCAAAAGCGGGCCTGTGGCAGCGCACGGTTTCCACGCTGGAAACCGGCGCGGCGGATGCAAGGCTGGAAA
CGCTGTTTGATCTGCTCGCCGCGCTGGATCTGGAATTGCAGGTCGTGCCGCGCAGCCGCACCGATCCCGACAGTTTTGCC
GATCTGTTCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References