Detailed information of TA system TA057450

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): BrnTA/BrnT-BrnA
• Location: 1177660..1178195
• Replicon: chromosome
• Accession: NZ_CP012908
• Organism: Ketogulonicigenium vulgare strain Hbe602

Toxin (Protein)

• Gene name: brnT
• Uniprot ID: -
• Locus tag: KVH_RS05995
• Protein ID: WP_013384044.1
• Coordinates: 1177947..1178195 (-)
• Length: 83 a.a.

Antitoxin (Protein)

• Gene name: brnA
• Uniprot ID: F9Y4N2
• Locus tag: KVH_RS05990
• Protein ID: WP_013384043.1
• Coordinates: 1177660..1177950 (-)
• Length: 97 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
KVH_RS05950	1172796..1173200	+	405	WP_013384036.1	hypothetical protein	-
KVH_RS05955	1173197..1174351	+	1155	WP_013384037.1	hypothetical protein	-
KVH_RS05960	1174351..1174614	+	264	WP_013384038.1	hypothetical protein	-
KVH_RS05965	1174727..1175356	+	630	WP_044008023.1	TetR/AcrR family transcriptional regulator	-
KVH_RS05970	1175356..1175691	+	336	WP_014537641.1	DoxX family protein	-
KVH_RS05975	1175839..1176102	+	264	WP_013384040.1	hypothetical protein	-
KVH_RS05980	1176102..1177406	+	1305	WP_060486249.1	hypothetical protein	-
KVH_RS05985	1177421..1177648	+	228	WP_013384042.1	hypothetical protein	-
KVH_RS05990	1177660..1177950	-	291	WP_013384043.1	BrnA antitoxin family protein	Antitoxin
KVH_RS05995	1177947..1178195	-	249	WP_013384044.1	BrnT family toxin	Toxin
KVH_RS06000	1178292..1178834	+	543	WP_013384045.1	lysozyme	-
KVH_RS06005	1178838..1179059	+	222	WP_013384046.1	hypothetical protein	-
KVH_RS16680	1179059..1179274	+	216	WP_162467560.1	hypothetical protein	-
KVH_RS06015	1179465..1179923	-	459	WP_014537644.1	sigma-70 family RNA polymerase sigma factor	-
KVH_RS06020	1180225..1181151	-	927	WP_014537645.1	SDR family NAD(P)-dependent oxidoreductase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	-	1138714..1178834	40120

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Ribonuclease toxin, BrnT, of type II toxin-antitoxin system (6-78)

Antitoxin

• BrnA antitoxin of type II toxin-antitoxin system (20-94)

Sequences

Toxin

Protein

• Length: 83 a.a.
• Molecular weight: 9028.54 Da
• Isoelectric Point: 7.3199

>T57450 WP_013384044.1 NZ_CP012908:c1178195-1177947 [Ketogulonicigenium vulgare]
MMMIVWDEPKRESNLEKHGLDFADLSEEFFLSSVVVPAKNGRHMAIGKLADGTIAVVFATLGTQGLSVISMRHASKKERA
IL

Nucleotide

• Length: 249 bp

>T57450 NZ_CP012908:c1178195-1177947 [Ketogulonicigenium vulgare]
ATGATGATGATTGTCTGGGATGAACCGAAACGCGAAAGCAACCTCGAGAAACACGGGTTAGATTTCGCAGATTTGTCCGA
GGAATTCTTTCTGTCCTCGGTCGTTGTCCCGGCAAAGAACGGGCGTCACATGGCGATAGGGAAGCTTGCCGACGGAACGA
TTGCAGTGGTCTTTGCCACACTTGGAACGCAAGGCCTGTCGGTGATTTCGATGCGCCACGCCAGCAAAAAGGAAAGGGCG
ATCCTATGA

Antitoxin

Protein

• Length: 97 a.a.
• Molecular weight: 10567.07 Da
• Isoelectric Point: 10.4185

>AT57450 WP_013384043.1 NZ_CP012908:c1177950-1177660 [Ketogulonicigenium vulgare]
MKANKLTEKEIQRRIASDPDAPEATDDQLAKAKPFAEAMPQLAENLRRNLGGRPKSDNPKVAVSLRLDQDVIEKFKAAGP
GWQSRMNKALREAAGV

Nucleotide

• Length: 291 bp

>AT57450 NZ_CP012908:c1177950-1177660 [Ketogulonicigenium vulgare]
ATGAAAGCCAACAAGCTAACCGAGAAAGAAATCCAACGCCGGATCGCAAGCGACCCGGACGCACCCGAGGCAACAGATGA
CCAGCTGGCGAAGGCGAAGCCCTTCGCCGAGGCCATGCCCCAACTGGCAGAGAACCTGCGCCGCAACCTTGGCGGCCGCC
CGAAATCCGACAACCCCAAAGTCGCGGTTTCGCTGCGCCTCGATCAAGACGTGATTGAGAAGTTCAAGGCCGCTGGCCCC
GGCTGGCAGTCGCGCATGAACAAAGCCCTGCGCGAAGCTGCGGGGGTATGA

Structures

Antitoxin

• AlphaFold DB: F9Y4N2