Detailed information of TA system TA057448

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): parDE/RHH(antitoxin)
• Location: 6818799..6819304
• Replicon: chromosome
• Accession: NZ_CP012901
• Organism: Pseudomonas aeruginosa strain N15-01092

Toxin (Protein)

• Gene name: parE
• Uniprot ID: -
• Locus tag: AOY09_RS32775
• Protein ID: WP_034037564.1
• Coordinates: 6819023..6819304 (+)
• Length: 94 a.a.

Antitoxin (Protein)

• Gene name: parD
• Uniprot ID: A0A1C7BDS9
• Locus tag: AOY09_RS32770
• Protein ID: WP_003083775.1
• Coordinates: 6818799..6819026 (+)
• Length: 76 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
AOY09_RS32745	6813817..6815310	+	1494	WP_003101230.1	CoA-acylating methylmalonate-semialdehyde dehydrogenase	-
AOY09_RS32750	6815479..6816906	+	1428	WP_003083784.1	GABA permease	-
AOY09_RS32755	6816988..6817329	-	342	WP_003101229.1	alkylphosphonate utilization protein	-
AOY09_RS32760	6817402..6817902	-	501	WP_003101228.1	LEA type 2 family protein	-
AOY09_RS32765	6818003..6818623	+	621	WP_034037566.1	hypothetical protein	-
AOY09_RS32770	6818799..6819026	+	228	WP_003083775.1	CopG family ribbon-helix-helix protein	Antitoxin
AOY09_RS32775	6819023..6819304	+	282	WP_034037564.1	type II toxin-antitoxin system toxin ParE	Toxin
AOY09_RS32780	6819604..6820512	+	909	WP_016561475.1	LysR family transcriptional regulator	-
AOY09_RS32785	6820544..6820930	-	387	WP_014602345.1	aegerolysin family protein	-
AOY09_RS32790	6821134..6821868	-	735	WP_003117208.1	GntR family transcriptional regulator	-
AOY09_RS32795	6821969..6822655	-	687	WP_003083762.1	FadR family transcriptional regulator	-
AOY09_RS32800	6822704..6824053	-	1350	WP_003142411.1	C4-dicarboxylate transporter DctA	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (3-87)

Antitoxin

• Ribbon-helix-helix protein, CopG (5-42)

Sequences

Toxin

Protein

• Length: 94 a.a.
• Molecular weight: 10458.20 Da
• Isoelectric Point: 10.0435

>T57448 WP_034037564.1 NZ_CP012901:6819023-6819304 [Pseudomonas aeruginosa]
MSLKWTRKAAADLDAIYDHYVVLIGPEKALKAVQDIVEQVKPLQQVANQGAGRPSEVPGVRTLPLERWPFSAPFRVKGKE
IQILRIDRVEITP

Nucleotide

• Length: 282 bp

>T57448 NZ_CP012901:6819023-6819304 [Pseudomonas aeruginosa]
ATGAGCCTGAAGTGGACCCGCAAGGCGGCCGCCGACCTGGACGCCATCTACGACCATTACGTCGTGCTGATCGGCCCGGA
AAAAGCTCTGAAAGCCGTTCAGGACATCGTCGAGCAGGTGAAACCGCTGCAGCAGGTAGCCAACCAGGGGGCAGGGCGGC
CCAGCGAGGTGCCAGGCGTACGCACCCTGCCCCTGGAGCGCTGGCCGTTCAGCGCCCCGTTTCGGGTTAAAGGCAAGGAA
ATCCAGATTTTGCGCATCGACAGGGTCGAAATTACCCCCTGA

Antitoxin

Protein

• Length: 76 a.a.
• Molecular weight: 8556.58 Da
• Isoelectric Point: 5.5740

>AT57448 WP_003083775.1 NZ_CP012901:6818799-6819026 [Pseudomonas aeruginosa]
MSTVVSFRADDALVAALDELARATHRDRPYHLRQALAQYLERQQWQVAAIDEGLADANAGRLLEHTEIEKRWGLQ

Nucleotide

• Length: 228 bp

>AT57448 NZ_CP012901:6818799-6819026 [Pseudomonas aeruginosa]
ATGAGCACCGTAGTCTCGTTCCGCGCCGATGACGCCCTGGTCGCGGCCCTCGACGAACTGGCCCGCGCCACCCACCGCGA
CCGCCCCTACCACCTGCGGCAGGCGCTCGCGCAGTACCTGGAAAGGCAGCAGTGGCAGGTCGCTGCCATCGATGAAGGCT
TGGCCGATGCCAATGCCGGTCGCCTGCTGGAACACACCGAGATCGAGAAGCGCTGGGGGCTGCAATGA

Structures

Antitoxin

• AlphaFold DB: A0A1C7BDS9