Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/RelE-RelB
Location 1603971..1604544 Replicon chromosome
Accession NZ_CP012901
Organism Pseudomonas aeruginosa strain N15-01092

Toxin (Protein)


Gene name relE Uniprot ID W5IUR0
Locus tag AOY09_RS07395 Protein ID WP_009618209.1
Coordinates 1604257..1604544 (+) Length 96 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID W5ISI7
Locus tag AOY09_RS07390 Protein ID WP_009618210.1
Coordinates 1603971..1604270 (+) Length 100 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
AOY09_RS07360 1599073..1599291 + 219 WP_011829925.1 AlpA family transcriptional regulator -
AOY09_RS07365 1599332..1600198 + 867 WP_018076212.1 ParA family protein -
AOY09_RS07370 1600182..1600418 + 237 WP_013982111.1 type II toxin-antitoxin system HicA family toxin -
AOY09_RS07375 1600411..1602069 + 1659 WP_018076213.1 ParB family protein -
AOY09_RS07380 1602087..1602647 + 561 WP_018076214.1 DUF2857 domain-containing protein -
AOY09_RS07385 1602650..1603843 + 1194 WP_017244810.1 hypothetical protein -
AOY09_RS07390 1603971..1604270 + 300 WP_009618210.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
AOY09_RS07395 1604257..1604544 + 288 WP_009618209.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
AOY09_RS07400 1604573..1604764 + 192 WP_011805449.1 hypothetical protein -
AOY09_RS07405 1604888..1605667 + 780 WP_017244811.1 TIGR03761 family integrating conjugative element protein -
AOY09_RS07410 1605664..1606212 + 549 WP_017244812.1 DUF3158 family protein -
AOY09_RS07415 1606209..1606658 + 450 WP_119163122.1 single-stranded DNA-binding protein -
AOY09_RS07420 1606941..1608956 + 2016 WP_003141052.1 DNA topoisomerase III -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Integrative and Conjugative Element - - 1584920..1663382 78462


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(4-90)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(4-58)


Sequences

Toxin        


Download         Length: 96 a.a.        Molecular weight: 10854.46 Da        Isoelectric Point: 8.4628

>T57443 WP_009618209.1 NZ_CP012901:1604257-1604544 [Pseudomonas aeruginosa]
VRVLEWREAARADLLAIVDYISDDNPDAAQRLKDDIEAKAAKLPERPKLYRPGRVAGTREMVVRANYVVVYMEDTRAVSI
LRVLHAAQQWPPARE

Download         Length: 288 bp

>T57443 NZ_CP012901:1604257-1604544 [Pseudomonas aeruginosa]
GTGCGCGTACTTGAGTGGCGGGAAGCTGCCCGCGCCGACCTGCTGGCGATTGTTGACTACATCTCGGACGACAACCCCGA
TGCCGCGCAGCGGTTGAAGGACGACATCGAGGCCAAGGCCGCGAAGCTGCCGGAGCGCCCGAAGCTCTACCGGCCTGGCC
GCGTGGCCGGCACGCGGGAGATGGTCGTGCGTGCGAACTACGTGGTGGTCTACATGGAGGACACCCGCGCGGTGTCCATC
CTGCGCGTGTTGCACGCCGCGCAGCAGTGGCCGCCGGCACGGGAGTGA

Antitoxin


Download         Length: 100 a.a.        Molecular weight: 10816.46 Da        Isoelectric Point: 8.6579

>AT57443 WP_009618210.1 NZ_CP012901:1603971-1604270 [Pseudomonas aeruginosa]
MAAQTSMLHIRVDDKLKADAAEKLAGVGLTVSDAVRILLTRVVKEGALPAGLTADPEAYDAWFRAKVQEALADTRPPVPH
QQVMDEAQALIDRKRRART

Download         Length: 300 bp

>AT57443 NZ_CP012901:1603971-1604270 [Pseudomonas aeruginosa]
ATGGCCGCACAGACTTCGATGCTGCACATCCGCGTGGACGATAAGCTCAAGGCCGATGCAGCCGAGAAACTCGCCGGGGT
CGGCCTCACCGTTTCGGACGCCGTGCGCATCCTGCTGACCCGTGTGGTCAAGGAAGGCGCACTGCCGGCTGGCCTCACGG
CCGACCCGGAGGCCTACGATGCCTGGTTCCGGGCGAAGGTCCAGGAGGCGCTGGCCGACACACGGCCGCCGGTGCCGCAC
CAGCAGGTCATGGATGAGGCGCAGGCCCTGATCGACAGGAAGCGGCGTGCGCGTACTTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A5R9QF16

Antitoxin

Source ID Structure
AlphaFold DB A0A5R9QE11

References