Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/PIN(toxin)
Location 3446751..3447430 Replicon chromosome
Accession NZ_CP012900
Organism Stenotrophomonas acidaminiphila strain ZAC14D2_NAIMI4_2

Toxin (Protein)


Gene name vapC Uniprot ID A0A0S1B316
Locus tag AOT14_RS15150 Protein ID WP_054667732.1
Coordinates 3447002..3447430 (+) Length 143 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID A0A0S1B352
Locus tag AOT14_RS15145 Protein ID WP_054667729.1
Coordinates 3446751..3447002 (+) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
AOT14_RS15135 3442396..3442950 + 555 WP_054667726.1 queuosine precursor transporter -
AOT14_RS15140 3443847..3446651 - 2805 WP_054667727.1 bifunctional [glutamate--ammonia ligase]-adenylyl-L-tyrosine phosphorylase/[glutamate--ammonia-ligase] adenylyltransferase -
AOT14_RS15145 3446751..3447002 + 252 WP_054667729.1 hypothetical protein Antitoxin
AOT14_RS15150 3447002..3447430 + 429 WP_054667732.1 PIN domain-containing protein Toxin
AOT14_RS15155 3447734..3449248 + 1515 WP_054667733.1 acetyl-CoA hydrolase/transferase family protein -
AOT14_RS15160 3449318..3449656 - 339 WP_054667735.1 YegP family protein -
AOT14_RS15165 3449789..3450049 - 261 WP_054667736.1 GIY-YIG nuclease family protein -
AOT14_RS15170 3450068..3450511 - 444 WP_162486463.1 hypothetical protein -
AOT14_RS15175 3450659..3451732 - 1074 WP_054667739.1 3-deoxy-7-phosphoheptulonate synthase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(4-127)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 143 a.a.        Molecular weight: 15822.24 Da        Isoelectric Point: 10.2505

>T57440 WP_054667732.1 NZ_CP012900:3447002-3447430 [Stenotrophomonas acidaminiphila]
MRALLDVNVLIALHDSDHVHHHPASAWLRTHIAHGWASCPLTQNGCLRIMSQPGYAKPQPLGSLVSMLARSTSTRFHAFW
PDAISVLDRTRFQHGYIHSPRQLTDLYLLALAVHHGGRLVTFNRHIALSAVAGARPEHLVQL

Download         Length: 429 bp

>T57440 NZ_CP012900:3447002-3447430 [Stenotrophomonas acidaminiphila]
ATGCGTGCGTTGCTCGACGTGAACGTGCTGATCGCACTGCACGACAGCGACCACGTCCACCATCACCCTGCCTCGGCCTG
GCTGCGCACGCATATCGCGCATGGCTGGGCCAGTTGTCCGCTTACCCAGAACGGTTGCCTGCGCATCATGTCCCAGCCCG
GATACGCCAAGCCGCAACCGCTGGGCAGCCTGGTGAGCATGCTGGCGCGTTCCACGTCCACGCGCTTCCATGCGTTCTGG
CCGGACGCCATCAGCGTGCTGGATCGCACGCGTTTCCAGCATGGCTACATCCACAGTCCGCGACAGTTGACCGATCTGTA
CCTGCTGGCGCTCGCGGTGCACCACGGCGGGCGGCTGGTGACCTTCAACCGGCACATTGCGCTGAGTGCGGTAGCGGGCG
CGCGGCCCGAGCACCTGGTGCAGTTGTAA

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9124.39 Da        Isoelectric Point: 4.7962

>AT57440 WP_054667729.1 NZ_CP012900:3446751-3447002 [Stenotrophomonas acidaminiphila]
MRTTLDIADDVLFAAKELARREKKPLGQVISELARRAFAQSDAPWGTTGVAEPLADYGIHPLPPRGVVVSNELIDRLRDE
EGI

Download         Length: 252 bp

>AT57440 NZ_CP012900:3446751-3447002 [Stenotrophomonas acidaminiphila]
ATGCGCACCACCCTCGACATCGCCGACGACGTGCTGTTTGCCGCCAAGGAGCTGGCACGCCGCGAGAAGAAGCCACTCGG
CCAGGTGATCAGCGAACTGGCGCGGCGGGCGTTCGCCCAGTCCGATGCCCCCTGGGGCACGACCGGCGTGGCCGAACCCC
TGGCCGATTACGGCATTCATCCGCTGCCGCCTCGCGGCGTGGTGGTCAGCAATGAACTCATCGACCGCCTGCGCGACGAA
GAGGGCATCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0S1B316

Antitoxin

Source ID Structure
AlphaFold DB A0A0S1B352

References