57439

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/PemK-PrlF
Location 3372319..3372856 Replicon chromosome
Accession NZ_CP012897
Organism Brevundimonas sp. DS20

Toxin (Protein)


Gene name mazF Uniprot ID A0A0P0DMR9
Locus tag JL11_RS16585 Protein ID WP_054766634.1
Coordinates 3372521..3372856 (+) Length 112 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID A0A0P0CT78
Locus tag JL11_RS16580 Protein ID WP_054766633.1
Coordinates 3372319..3372534 (+) Length 72 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JL11_RS16565 3369000..3369782 - 783 WP_156314220.1 ZIP family metal transporter -
JL11_RS16570 3369847..3371004 + 1158 WP_054766631.1 glutamate 5-kinase -
JL11_RS16575 3371001..3372272 + 1272 WP_054766632.1 glutamate-5-semialdehyde dehydrogenase -
JL11_RS16580 3372319..3372534 + 216 WP_054766633.1 type II toxin-antitoxin system PrlF family antitoxin Antitoxin
JL11_RS16585 3372521..3372856 + 336 WP_054766634.1 type II toxin-antitoxin system PemK/MazF family toxin Toxin
JL11_RS16590 3372913..3375336 - 2424 WP_054766635.1 membrane-bound PQQ-dependent dehydrogenase, glucose/quinate/shikimate family -
JL11_RS16595 3375566..3376993 + 1428 WP_054766636.1 NAD(P)-dependent oxidoreductase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(5-108)

Antitoxin

PrlF antitoxin

(4-52)


Sequences

Toxin        


Download         Length: 112 a.a.        Molecular weight: 12377.26 Da        Isoelectric Point: 9.7716

>T57439 WP_054766634.1 NZ_CP012897:3372521-3372856 [Brevundimonas sp. DS20]
MPDFERGDVVRVPFPYTDRNTRQHRPAMVVSNGPLGESDRLLWVVMITSAENRRWAEDVPLDEDYAAAGLPAPSLIRPVK
IATIDAAVAKKLGRIDPDRLARAMQSVRAKL

Download         Length: 336 bp

>T57439 NZ_CP012897:3372521-3372856 [Brevundimonas sp. DS20]
ATGCCGGACTTTGAGCGCGGAGACGTCGTCCGCGTCCCTTTCCCCTACACCGATCGGAACACACGCCAGCACCGCCCTGC
TATGGTCGTGTCCAACGGTCCGCTTGGCGAGTCGGACCGGCTGTTATGGGTAGTGATGATCACCAGCGCCGAGAACCGCA
GATGGGCGGAGGATGTGCCGCTGGACGAGGACTATGCCGCTGCCGGTCTGCCGGCGCCCTCGTTAATTCGTCCGGTCAAG
ATCGCCACCATAGATGCAGCCGTGGCTAAGAAGCTGGGGCGGATCGATCCGGACCGGCTGGCGCGAGCGATGCAGTCGGT
GCGCGCCAAGCTCTGA

Antitoxin


Download         Length: 72 a.a.        Molecular weight: 7982.92 Da        Isoelectric Point: 4.6750

>AT57439 WP_054766633.1 NZ_CP012897:3372319-3372534 [Brevundimonas sp. DS20]
MIKSRLTSKAQTTIPQAVRTALNLQDGDEIQYDLVGDRAILRKAWRAPADDPFSAFDEWDTEADRKAYAGL

Download         Length: 216 bp

>AT57439 NZ_CP012897:3372319-3372534 [Brevundimonas sp. DS20]
ATGATCAAAAGCCGCCTCACATCCAAGGCCCAGACCACCATCCCGCAGGCCGTCCGCACGGCGTTGAATCTGCAGGACGG
CGACGAGATCCAGTATGATCTGGTCGGCGACCGAGCCATTCTGCGCAAGGCGTGGCGCGCGCCTGCGGACGATCCGTTCA
GCGCCTTCGACGAATGGGACACCGAGGCGGACCGCAAGGCCTATGCCGGACTTTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0P0DMR9

Antitoxin

Source ID Structure
AlphaFold DB A0A0P0CT78

References