57438

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) parDE/CC2985(antitoxin)
Location 3311778..3312343 Replicon chromosome
Accession NZ_CP012897
Organism Brevundimonas sp. DS20

Toxin (Protein)


Gene name parE Uniprot ID A0A0P0DEU7
Locus tag JL11_RS16245 Protein ID WP_054766572.1
Coordinates 3312023..3312343 (+) Length 107 a.a.

Antitoxin (Protein)


Gene name parD Uniprot ID A0A0P0D2E3
Locus tag JL11_RS16240 Protein ID WP_054766571.1
Coordinates 3311778..3312023 (+) Length 82 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JL11_RS16225 3307597..3308322 + 726 WP_054766568.1 16S rRNA (uracil(1498)-N(3))-methyltransferase -
JL11_RS16230 3308600..3309961 + 1362 WP_054766569.1 glutamate--cysteine ligase -
JL11_RS16235 3310021..3311643 + 1623 WP_054766570.1 response regulator -
JL11_RS16240 3311778..3312023 + 246 WP_054766571.1 type II toxin-antitoxin system ParD family antitoxin Antitoxin
JL11_RS16245 3312023..3312343 + 321 WP_054766572.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
JL11_RS16250 3312340..3313089 + 750 WP_054766573.1 DUF72 domain-containing protein -
JL11_RS16255 3313165..3314220 + 1056 WP_191558703.1 NAD(P)-dependent alcohol dehydrogenase -
JL11_RS16260 3314342..3315067 + 726 WP_054766575.1 acetoacetyl-CoA reductase -
JL11_RS16265 3315116..3315886 + 771 WP_054766576.1 DUF4908 domain-containing protein -
JL11_RS16270 3315876..3316604 - 729 WP_054766577.1 hydroxyacylglutathione hydrolase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(2-90)

Antitoxin

Antitoxin ParD

(3-68)


Sequences

Toxin        


Download         Length: 107 a.a.        Molecular weight: 12070.51 Da        Isoelectric Point: 4.5960

>T57438 WP_054766572.1 NZ_CP012897:3312023-3312343 [Brevundimonas sp. DS20]
MLRLSREARADLQQVYLQGLELFGSRQADDYIEGLFAKLDLLTDFPRLGAARPELSADAHVMFYKSHAVLYRIDDADVFI
RRIRHALEDWQSDGSEVGSKDEGSEP

Download         Length: 321 bp

>T57438 NZ_CP012897:3312023-3312343 [Brevundimonas sp. DS20]
ATGCTTCGCCTGAGCCGCGAGGCGCGGGCGGACTTGCAGCAGGTCTATTTGCAAGGTCTGGAACTGTTTGGGAGCCGTCA
GGCCGATGACTATATCGAGGGCCTGTTCGCGAAACTGGATTTGCTTACGGACTTCCCCCGGCTCGGAGCCGCTCGGCCCG
AGTTGAGCGCGGACGCTCACGTGATGTTCTACAAGAGCCATGCCGTCCTCTATCGGATCGACGATGCGGACGTGTTTATC
CGACGCATTCGGCACGCGCTTGAGGATTGGCAATCCGATGGCTCTGAGGTCGGATCGAAAGACGAAGGGAGCGAACCATG
A

Antitoxin


Download         Length: 82 a.a.        Molecular weight: 9189.37 Da        Isoelectric Point: 5.8451

>AT57438 WP_054766571.1 NZ_CP012897:3311778-3312023 [Brevundimonas sp. DS20]
MATMNISLPDPMKAWVEEQAQSGRYANASDVIRDLIRREQVKAEKIAHWQRLIAEADASGVSDQSPREVIEELRAQLRRA
S

Download         Length: 246 bp

>AT57438 NZ_CP012897:3311778-3312023 [Brevundimonas sp. DS20]
ATGGCTACGATGAACATCTCCCTGCCCGACCCGATGAAGGCCTGGGTCGAGGAACAGGCCCAATCGGGCCGCTACGCCAA
CGCCTCCGACGTCATCCGCGACCTGATCCGCCGCGAGCAGGTCAAGGCGGAAAAGATCGCGCACTGGCAAAGATTGATCG
CAGAGGCCGACGCCTCTGGCGTTTCCGATCAGTCTCCGCGTGAAGTGATTGAGGAACTGCGCGCCCAGTTGCGCCGCGCC
TCCTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0P0DEU7

Antitoxin

Source ID Structure
AlphaFold DB A0A0P0D2E3

References