Detailed information of TA system TA057436

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): stbE-relB/ParE-YafN
• Location: 3100977..3101496
• Replicon: chromosome
• Accession: NZ_CP012897
• Organism: Brevundimonas sp. DS20

Toxin (Protein)

• Gene name: stbE
• Uniprot ID: A0A0P0CXI5
• Locus tag: JL11_RS15215
• Protein ID: WP_054766396.1
• Coordinates: 3101212..3101496 (+)
• Length: 95 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: A0A0P0DE96
• Locus tag: JL11_RS15210
• Protein ID: WP_054766395.1
• Coordinates: 3100977..3101222 (+)
• Length: 82 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
JL11_RS15190	3096872..3097147	-	276	WP_007445714.1	DUF2849 domain-containing protein	-
JL11_RS15195	3097144..3098529	-	1386	WP_054767021.1	siroheme synthase CysG	-
JL11_RS15200	3098652..3099581	+	930	WP_054766393.1	transcriptional regulator GcvA	-
JL11_RS15205	3099632..3100933	+	1302	WP_054766394.1	adenylosuccinate lyase	-
JL11_RS15210	3100977..3101222	+	246	WP_054766395.1	type II toxin-antitoxin system Phd/YefM family antitoxin	Antitoxin
JL11_RS15215	3101212..3101496	+	285	WP_054766396.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
JL11_RS15220	3101493..3101996	+	504	WP_054766397.1	DNA-deoxyinosine glycosylase	-
JL11_RS15225	3101996..3102838	+	843	WP_054766398.1	formyltetrahydrofolate deformylase	-
JL11_RS15230	3102944..3103570	+	627	WP_054766399.1	fasciclin domain-containing protein	-
JL11_RS15235	3103753..3104076	-	324	WP_054767022.1	DUF1476 domain-containing protein	-
JL11_RS15240	3104355..3105113	+	759	WP_054766400.1	phosphoribosylaminoimidazolesuccinocarboxamide synthase	-
JL11_RS15245	3105113..3105316	+	204	WP_054766401.1	hypothetical protein	-
JL11_RS15250	3105316..3105600	+	285	WP_054766402.1	hypothetical protein	-
JL11_RS15255	3105600..3105836	+	237	WP_054766403.1	phosphoribosylformylglycinamidine synthase subunit PurS	-
JL11_RS15260	3105933..3106412	+	480	WP_054766404.1	YbhB/YbcL family Raf kinase inhibitor-like protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (5-87)

Antitoxin

• Type II toxin-antitoxin system, antitoxin Phd/YefM (9-71)

Sequences

Toxin

Protein

• Length: 95 a.a.
• Molecular weight: 11007.82 Da
• Isoelectric Point: 10.7091

>T57436 WP_054766396.1 NZ_CP012897:3101212-3101496 [Brevundimonas sp. DS20]
MPFDLQFLPSALKEWEKLGAPVRVQFKKKLAERLESPRVPKDALHGMRDHYKIKLRDAGYRLVYRVEDAIVTVTVVAVGR
RDRSQVYRDAARRE

Nucleotide

• Length: 285 bp

>T57436 NZ_CP012897:3101212-3101496 [Brevundimonas sp. DS20]
ATGCCCTTTGATCTTCAGTTCCTCCCCTCCGCGCTGAAGGAGTGGGAGAAGCTGGGCGCTCCGGTCCGGGTCCAGTTCAA
GAAAAAGCTCGCCGAACGACTGGAGAGTCCGCGTGTTCCGAAGGATGCGCTCCACGGGATGCGCGATCACTACAAGATCA
AGCTGCGCGACGCCGGATATCGGCTGGTCTATCGGGTCGAGGACGCAATCGTCACGGTGACCGTCGTCGCGGTGGGCAGA
CGCGACCGCAGCCAGGTGTATCGGGACGCGGCGCGTCGGGAATGA

Antitoxin

Protein

• Length: 82 a.a.
• Molecular weight: 8843.14 Da
• Isoelectric Point: 4.4865

>AT57436 WP_054766395.1 NZ_CP012897:3100977-3101222 [Brevundimonas sp. DS20]
MQRVEASIAVSVSDLKKSPSAVMDDAAGQTVAVLNHNRVMAYMVPAAAYEAMIERLDDLALIETVRQRQDETPVRVSLDA
L

Nucleotide

• Length: 246 bp

>AT57436 NZ_CP012897:3100977-3101222 [Brevundimonas sp. DS20]
ATGCAACGCGTCGAAGCCTCTATCGCGGTCAGCGTCTCTGACCTGAAGAAGAGCCCCAGCGCCGTCATGGACGACGCGGC
GGGCCAGACCGTGGCCGTGCTGAACCACAACCGGGTCATGGCCTATATGGTCCCGGCCGCCGCCTATGAGGCGATGATCG
AACGCCTGGACGATCTGGCCTTGATCGAGACTGTCCGCCAGCGGCAGGACGAGACGCCGGTGCGCGTCTCGCTCGATGCC
CTTTGA

Structures

Toxin

• AlphaFold DB: A0A0P0CXI5

Antitoxin

• AlphaFold DB: A0A0P0DE96