57435

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/DUF433(antitoxin)
Location 2804283..2804842 Replicon chromosome
Accession NZ_CP012897
Organism Brevundimonas sp. DS20

Toxin (Protein)


Gene name vapC Uniprot ID A0A0P0D782
Locus tag JL11_RS13750 Protein ID WP_054766147.1
Coordinates 2804510..2804842 (+) Length 111 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID A0A0P0CRE5
Locus tag JL11_RS13745 Protein ID WP_054766146.1
Coordinates 2804283..2804513 (+) Length 77 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JL11_RS13725 2799922..2800575 - 654 WP_054766143.1 squalene/phytoene synthase family protein -
JL11_RS13730 2800565..2801539 - 975 WP_054766991.1 polyprenyl synthetase family protein -
JL11_RS13735 2801706..2802461 + 756 WP_054766144.1 methyltransferase -
JL11_RS13740 2802591..2804258 + 1668 WP_054766145.1 energy-dependent translational throttle protein EttA -
JL11_RS13745 2804283..2804513 + 231 WP_054766146.1 DUF433 domain-containing protein Antitoxin
JL11_RS13750 2804510..2804842 + 333 WP_054766147.1 DUF5615 family PIN-like protein Toxin
JL11_RS13755 2804839..2805765 + 927 WP_054766148.1 2-hydroxyacid dehydrogenase -
JL11_RS13760 2805766..2806170 - 405 WP_054766149.1 EF-hand domain-containing protein -
JL11_RS13765 2806288..2807262 + 975 WP_054766150.1 metalloregulator ArsR/SmtB family transcription factor -
JL11_RS13770 2807259..2808215 + 957 WP_054766151.1 methylenetetrahydrofolate reductase [NAD(P)H] -
JL11_RS13775 2808215..2809321 + 1107 WP_054766152.1 homocysteine S-methyltransferase family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Domain of unknown function DUF5615

(2-77)

Antitoxin

Protein of unknown function DUF433

(9-64)


Sequences

Toxin        


Download         Length: 111 a.a.        Molecular weight: 12615.58 Da        Isoelectric Point: 7.4063

>T57435 WP_054766147.1 NZ_CP012897:2804510-2804842 [Brevundimonas sp. DS20]
VKFIVDAQLPIALADWLRANGHAADHVSTLLAVHARDQDIWDLARAESRVIITKDRDFAIWAADRRLGPQIVWLRLGNAT
RRVLIEWLEPRWARIEQGLLDGLHLIEVRA

Download         Length: 333 bp

>T57435 NZ_CP012897:2804510-2804842 [Brevundimonas sp. DS20]
GTGAAATTCATCGTGGACGCCCAGCTGCCTATCGCTCTTGCCGATTGGCTGAGAGCTAATGGGCACGCGGCCGACCATGT
TTCCACGCTTCTGGCGGTACATGCGCGTGACCAGGACATCTGGGATTTGGCCCGAGCGGAATCGCGCGTCATCATCACCA
AGGATCGGGACTTCGCCATCTGGGCGGCGGACCGCCGGCTAGGGCCTCAGATCGTCTGGCTTCGTCTTGGCAACGCGACC
CGGCGTGTGCTGATCGAATGGCTTGAACCCCGATGGGCCAGGATCGAACAAGGCCTCCTCGACGGCCTCCATTTGATCGA
GGTGCGCGCATGA

Antitoxin


Download         Length: 77 a.a.        Molecular weight: 7983.07 Da        Isoelectric Point: 3.9918

>AT57435 WP_054766146.1 NZ_CP012897:2804283-2804513 [Brevundimonas sp. DS20]
MSDDLLSRITIDPSQCGGRPCIRGMRIRVQDVLDMLAGGASPEEVLADFPYLEADDIRASLAYAAASIGDTGVIAA

Download         Length: 231 bp

>AT57435 NZ_CP012897:2804283-2804513 [Brevundimonas sp. DS20]
ATGAGCGACGATCTTCTGTCCCGCATCACCATTGATCCCAGCCAGTGCGGGGGCCGTCCGTGCATTCGAGGCATGCGAAT
TCGCGTGCAGGACGTTCTGGACATGCTGGCCGGTGGCGCGAGCCCGGAGGAAGTCCTCGCGGACTTTCCCTACCTGGAAG
CTGACGACATTCGGGCCAGCCTTGCCTATGCGGCCGCAAGCATCGGCGACACCGGCGTGATCGCCGCGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0P0D782

Antitoxin

Source ID Structure
AlphaFold DB A0A0P0CRE5

References