57434

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/PIN(toxin)
Location 1077110..1077771 Replicon chromosome
Accession NZ_CP012897
Organism Brevundimonas sp. DS20

Toxin (Protein)


Gene name vapC Uniprot ID A0A0P0DC47
Locus tag JL11_RS17115 Protein ID WP_054764716.1
Coordinates 1077110..1077547 (-) Length 146 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID A0A0P0DI52
Locus tag JL11_RS17635 Protein ID WP_054764717.1
Coordinates 1077544..1077771 (-) Length 76 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JL11_RS05145 1072588..1073013 + 426 WP_054764710.1 hypothetical protein -
JL11_RS05150 1073049..1074146 + 1098 WP_054764711.1 helix-turn-helix domain-containing protein -
JL11_RS05155 1074205..1074918 + 714 WP_054764712.1 CPBP family intramembrane metalloprotease -
JL11_RS05160 1075045..1075800 + 756 WP_054764713.1 protein TolQ -
JL11_RS05165 1075804..1076271 + 468 WP_054764714.1 protein TolR -
JL11_RS05170 1076276..1077106 + 831 WP_054764715.1 hypothetical protein -
JL11_RS17115 1077110..1077547 - 438 WP_054764716.1 DNA-binding protein Toxin
JL11_RS17635 1077544..1077771 - 228 WP_054764717.1 hypothetical protein Antitoxin
JL11_RS05185 1077916..1079286 + 1371 WP_054764718.1 Tol-Pal system protein TolB -
JL11_RS05190 1079440..1079997 + 558 WP_054764719.1 peptidoglycan-associated lipoprotein Pal -
JL11_RS05195 1080111..1081220 + 1110 WP_054764720.1 DUF3667 domain-containing protein -
JL11_RS05200 1081263..1082105 + 843 WP_054764721.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain toxin

(1-127)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 146 a.a.        Molecular weight: 15967.30 Da        Isoelectric Point: 6.9782

>T57434 WP_054764716.1 NZ_CP012897:c1077547-1077110 [Brevundimonas sp. DS20]
MTYLLDVNVLIALVDPRHVFHHPANTWFQREAAPSWATCPITENGLVRIVGSSRYRNPVGPPSDVVRILALLRDMAGHVF
WPDAVSLADERLFEPSALTKPEQITDAYLLALAVSNGGRLATFDRRLSPDAVKGGRSALHLITDT

Download         Length: 438 bp

>T57434 NZ_CP012897:c1077547-1077110 [Brevundimonas sp. DS20]
TTGACCTATCTGTTGGACGTGAACGTGCTGATCGCCCTCGTCGATCCCCGCCACGTCTTTCACCATCCTGCCAATACCTG
GTTCCAACGCGAAGCCGCTCCGTCCTGGGCCACCTGTCCGATAACCGAGAACGGTTTGGTCCGCATCGTCGGCAGCAGCC
GCTATCGCAATCCGGTCGGGCCGCCTTCCGATGTCGTTCGGATTCTCGCTCTGCTGCGAGACATGGCTGGTCACGTCTTT
TGGCCGGATGCCGTCAGTCTGGCCGACGAACGCCTGTTCGAGCCCTCGGCCCTGACCAAGCCGGAACAGATCACCGACGC
CTATCTCCTGGCTCTGGCGGTCTCGAACGGGGGCCGGCTTGCGACCTTCGATCGCCGACTGTCCCCAGACGCCGTCAAAG
GCGGACGATCGGCCCTTCACCTGATCACAGACACCTGA

Antitoxin


Download         Length: 76 a.a.        Molecular weight: 8322.49 Da        Isoelectric Point: 5.0336

>AT57434 WP_054764717.1 NZ_CP012897:c1077771-1077544 [Brevundimonas sp. DS20]
MRTTLAIDDDVLNAARALAAHQDRTVGEVMSELARQALQKRESTVRFRNGVPLLPDRPGPMVTLEDVNALRDELP

Download         Length: 228 bp

>AT57434 NZ_CP012897:c1077771-1077544 [Brevundimonas sp. DS20]
ATGCGCACCACCCTCGCCATAGACGACGACGTGCTGAATGCGGCTCGCGCCCTTGCCGCCCACCAGGACCGCACGGTGGG
TGAGGTGATGTCTGAACTCGCTCGTCAGGCGCTGCAAAAGCGTGAGAGCACGGTGCGCTTCCGCAACGGGGTTCCTCTTC
TGCCCGATCGGCCTGGGCCCATGGTCACGCTGGAAGACGTCAACGCCCTGCGTGACGAGCTGCCTTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0P0DC47

Antitoxin

Source ID Structure
AlphaFold DB A0A0P0DI52

References