Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) PumA-relB/COG3657-dnstrm_HI1420
Location 1031837..1032461 Replicon chromosome
Accession NZ_CP012897
Organism Brevundimonas sp. DS20

Toxin (Protein)


Gene name PumA Uniprot ID A0A0P0CXW0
Locus tag JL11_RS04950 Protein ID WP_054764677.1
Coordinates 1031837..1032163 (+) Length 109 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID A0A0P0DA33
Locus tag JL11_RS04955 Protein ID WP_054764678.1
Coordinates 1032153..1032461 (+) Length 103 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JL11_RS04930 1027725..1029482 - 1758 WP_054764675.1 hypothetical protein -
JL11_RS04940 1029927..1030388 - 462 WP_054766821.1 TIGR02300 family protein -
JL11_RS04945 1030513..1031832 + 1320 WP_054764676.1 3-phosphoshikimate 1-carboxyvinyltransferase -
JL11_RS04950 1031837..1032163 + 327 WP_054764677.1 addiction module antitoxin RelB Toxin
JL11_RS04955 1032153..1032461 + 309 WP_054764678.1 putative addiction module antidote protein Antitoxin
JL11_RS04960 1032461..1033105 + 645 WP_054764679.1 (d)CMP kinase -
JL11_RS04965 1033266..1034969 + 1704 WP_054764680.1 30S ribosomal protein S1 -
JL11_RS04970 1035372..1035662 + 291 WP_054766822.1 integration host factor subunit beta -
JL11_RS04975 1035686..1036102 + 417 WP_054764681.1 large-conductance mechanosensitive channel protein MscL -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Addiction module killer protein, predicted

(11-104)

Antitoxin

Uncharacterized protein HI1420

(8-94)


Sequences

Toxin        


Download         Length: 109 a.a.        Molecular weight: 12171.83 Da        Isoelectric Point: 8.5999

>T57433 WP_054764677.1 NZ_CP012897:1031837-1032163 [Brevundimonas sp. DS20]
MSPIDDSGDVEIELTPQFVAWRARLRDARALAKIADRLTRLQFGHWGDVKPIGEGVSELRIDVVPGYRVYAFQRNRTWVV
VPGGGDKSSQRRDIEAALLLARELRNAD

Download         Length: 327 bp

>T57433 NZ_CP012897:1031837-1032163 [Brevundimonas sp. DS20]
ATGTCGCCTATAGACGACAGTGGGGATGTTGAGATTGAACTGACGCCGCAGTTCGTCGCTTGGCGCGCTAGGCTGCGGGA
CGCACGGGCGTTGGCGAAGATCGCCGATCGGCTGACAAGGCTTCAGTTCGGGCACTGGGGCGACGTCAAACCCATCGGGG
AGGGCGTCAGCGAACTGCGGATCGACGTCGTTCCCGGCTACCGCGTGTACGCGTTCCAACGGAACCGCACCTGGGTCGTC
GTGCCTGGCGGAGGCGACAAGTCGTCCCAAAGGCGGGACATAGAGGCGGCCTTGCTTCTGGCGAGAGAGTTGAGAAATGC
CGATTGA

Antitoxin


Download         Length: 103 a.a.        Molecular weight: 10967.54 Da        Isoelectric Point: 4.2584

>AT57433 WP_054764678.1 NZ_CP012897:1032153-1032461 [Brevundimonas sp. DS20]
MPIETVPFDAADFLDTPEAVEEFLVASFESAAELGDPRLITNALGVVARAKGMSQMARDAELSRTALYRALSEDGRPELS
TIFKVMQALGLRLAPVRVDSAA

Download         Length: 309 bp

>AT57433 NZ_CP012897:1032153-1032461 [Brevundimonas sp. DS20]
ATGCCGATTGAGACTGTCCCCTTCGACGCCGCCGACTTTCTCGACACGCCGGAGGCGGTTGAAGAGTTTCTGGTGGCGTC
GTTTGAATCCGCCGCCGAACTGGGCGATCCGCGCCTGATCACAAATGCGCTCGGCGTGGTCGCCCGGGCCAAGGGCATGA
GCCAGATGGCGCGCGACGCCGAACTGTCGCGCACCGCCCTCTATCGCGCCCTCAGCGAAGACGGGCGGCCTGAGCTTTCG
ACCATCTTCAAGGTGATGCAGGCCCTGGGTCTTCGCCTCGCCCCTGTTCGCGTGGACTCCGCCGCCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0P0CXW0

Antitoxin

Source ID Structure
AlphaFold DB A0A0P0DA33

References