Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | pezAT/zeta-ParD |
| Location | 2742078..2743070 | Replicon | chromosome |
| Accession | NZ_CP012885 | ||
| Organism | Mycobacterium intracellulare subsp. chimaera strain AH16 | ||
Toxin (Protein)
| Gene name | pezT | Uniprot ID | A0A854HPC2 |
| Locus tag | AN480_RS12820 | Protein ID | WP_054585353.1 |
| Coordinates | 2742492..2743070 (+) | Length | 193 a.a. |
Antitoxin (Protein)
| Gene name | pezA | Uniprot ID | A0A854UQX7 |
| Locus tag | AN480_RS12815 | Protein ID | WP_054585352.1 |
| Coordinates | 2742078..2742467 (+) | Length | 130 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| AN480_RS12795 | 2737229..2737897 | - | 669 | WP_179300141.1 | hypothetical protein | - |
| AN480_RS12800 | 2737977..2739494 | + | 1518 | WP_054585349.1 | carboxylesterase/lipase family protein | - |
| AN480_RS12805 | 2739513..2741516 | + | 2004 | WP_054585350.1 | phosphotransferase | - |
| AN480_RS12810 | 2741513..2742007 | + | 495 | WP_054585351.1 | gluconokinase | - |
| AN480_RS12815 | 2742078..2742467 | + | 390 | WP_054585352.1 | hypothetical protein | Antitoxin |
| AN480_RS12820 | 2742492..2743070 | + | 579 | WP_054585353.1 | zeta toxin family protein | Toxin |
| AN480_RS12825 | 2743081..2744148 | - | 1068 | WP_054585354.1 | DoxX family membrane protein | - |
| AN480_RS12830 | 2744244..2744804 | + | 561 | WP_008256422.1 | pyrazinamidase PncA | - |
| AN480_RS12835 | 2744804..2745604 | + | 801 | WP_054585355.1 | nuclear transport factor 2 family protein | - |
| AN480_RS12840 | 2745616..2745966 | - | 351 | WP_054585356.1 | DoxX family protein | - |
| AN480_RS12845 | 2746132..2747103 | + | 972 | WP_054585357.1 | sigma-70 family RNA polymerase sigma factor | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 193 a.a. Molecular weight: 21127.16 Da Isoelectric Point: 10.7751
>T57430 WP_054585353.1 NZ_CP012885:2742492-2743070 [Mycobacterium intracellulare subsp. chimaera]
MQRLDLVVGPNGAGKSTFIAFTLAPLLPGSPVVNADEIARQRWPEESAGRAYDAAQIAADTRAKLIDLGRSFIAETVFSH
PSKLDLIRTAHRAGFTVVLHAMLIPEDLAVERVRHRVRAGGHDVPETKVRERHRRLWTPVTDAIALSDVATVYDNSRLRG
PRIVARLTGGMTIGSPDWPAWTPGTLRSRWAD
MQRLDLVVGPNGAGKSTFIAFTLAPLLPGSPVVNADEIARQRWPEESAGRAYDAAQIAADTRAKLIDLGRSFIAETVFSH
PSKLDLIRTAHRAGFTVVLHAMLIPEDLAVERVRHRVRAGGHDVPETKVRERHRRLWTPVTDAIALSDVATVYDNSRLRG
PRIVARLTGGMTIGSPDWPAWTPGTLRSRWAD
Download Length: 579 bp
>T57430 NZ_CP012885:2742492-2743070 [Mycobacterium intracellulare subsp. chimaera]
ATGCAGCGACTTGACCTGGTGGTCGGGCCGAACGGTGCCGGCAAGTCGACCTTCATCGCGTTCACCCTGGCGCCGCTGTT
GCCCGGCAGCCCGGTCGTCAACGCCGACGAAATCGCAAGGCAGCGCTGGCCGGAGGAGTCGGCGGGGCGCGCCTACGACG
CCGCGCAAATCGCCGCCGACACGCGCGCGAAGTTGATCGACCTGGGTCGGTCGTTCATCGCGGAGACCGTGTTTTCCCAC
CCGTCGAAGCTGGACCTCATCCGCACCGCCCACCGAGCGGGCTTCACCGTCGTCCTGCACGCGATGCTCATCCCGGAAGA
CCTTGCCGTCGAACGTGTCCGGCACCGCGTGCGGGCCGGCGGCCACGACGTACCGGAAACCAAGGTTCGCGAGCGCCATC
GTCGCTTGTGGACACCGGTCACCGACGCCATCGCGCTGTCCGACGTCGCCACCGTCTACGACAACAGCCGGCTGCGCGGG
CCGCGCATCGTCGCCCGCCTCACCGGCGGCATGACAATCGGTTCACCGGACTGGCCCGCGTGGACGCCAGGGACCTTGCG
GTCACGCTGGGCGGACTAA
ATGCAGCGACTTGACCTGGTGGTCGGGCCGAACGGTGCCGGCAAGTCGACCTTCATCGCGTTCACCCTGGCGCCGCTGTT
GCCCGGCAGCCCGGTCGTCAACGCCGACGAAATCGCAAGGCAGCGCTGGCCGGAGGAGTCGGCGGGGCGCGCCTACGACG
CCGCGCAAATCGCCGCCGACACGCGCGCGAAGTTGATCGACCTGGGTCGGTCGTTCATCGCGGAGACCGTGTTTTCCCAC
CCGTCGAAGCTGGACCTCATCCGCACCGCCCACCGAGCGGGCTTCACCGTCGTCCTGCACGCGATGCTCATCCCGGAAGA
CCTTGCCGTCGAACGTGTCCGGCACCGCGTGCGGGCCGGCGGCCACGACGTACCGGAAACCAAGGTTCGCGAGCGCCATC
GTCGCTTGTGGACACCGGTCACCGACGCCATCGCGCTGTCCGACGTCGCCACCGTCTACGACAACAGCCGGCTGCGCGGG
CCGCGCATCGTCGCCCGCCTCACCGGCGGCATGACAATCGGTTCACCGGACTGGCCCGCGTGGACGCCAGGGACCTTGCG
GTCACGCTGGGCGGACTAA
Antitoxin
Download Length: 130 a.a. Molecular weight: 13529.94 Da Isoelectric Point: 5.5559
>AT57430 WP_054585352.1 NZ_CP012885:2742078-2742467 [Mycobacterium intracellulare subsp. chimaera]
MADAPDRVTRVASDLMDSAASEGARQSRSAKQQLDHWARVGRAVSSQHTASRRRVEAAMAGQLATGELTVEEGVVFNAEI
SAAIEESLVHANYGATLAGHGVTTVALNEDGDIVEHRPDGAAVVLARGR
MADAPDRVTRVASDLMDSAASEGARQSRSAKQQLDHWARVGRAVSSQHTASRRRVEAAMAGQLATGELTVEEGVVFNAEI
SAAIEESLVHANYGATLAGHGVTTVALNEDGDIVEHRPDGAAVVLARGR
Download Length: 390 bp
>AT57430 NZ_CP012885:2742078-2742467 [Mycobacterium intracellulare subsp. chimaera]
ATGGCCGACGCTCCCGATCGTGTGACCCGCGTGGCGTCCGACCTGATGGACAGCGCGGCCTCCGAAGGCGCCCGCCAGAG
CCGTTCGGCCAAGCAGCAACTCGACCACTGGGCGCGTGTCGGGCGCGCGGTGTCCAGCCAGCACACCGCCTCGCGTCGGC
GGGTCGAGGCCGCGATGGCCGGCCAGCTGGCGACCGGCGAACTCACCGTCGAGGAAGGCGTGGTGTTCAACGCCGAGATC
TCCGCGGCTATTGAAGAAAGCCTGGTGCACGCCAACTACGGGGCGACGCTGGCCGGGCATGGCGTCACCACGGTCGCCCT
CAACGAGGACGGCGACATCGTCGAGCACCGGCCCGATGGCGCCGCCGTGGTGCTGGCGCGCGGGCGCTGA
ATGGCCGACGCTCCCGATCGTGTGACCCGCGTGGCGTCCGACCTGATGGACAGCGCGGCCTCCGAAGGCGCCCGCCAGAG
CCGTTCGGCCAAGCAGCAACTCGACCACTGGGCGCGTGTCGGGCGCGCGGTGTCCAGCCAGCACACCGCCTCGCGTCGGC
GGGTCGAGGCCGCGATGGCCGGCCAGCTGGCGACCGGCGAACTCACCGTCGAGGAAGGCGTGGTGTTCAACGCCGAGATC
TCCGCGGCTATTGAAGAAAGCCTGGTGCACGCCAACTACGGGGCGACGCTGGCCGGGCATGGCGTCACCACGGTCGCCCT
CAACGAGGACGGCGACATCGTCGAGCACCGGCCCGATGGCGCCGCCGTGGTGCTGGCGCGCGGGCGCTGA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
Structures
Toxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A854HPC2 |
Antitoxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A854UQX7 |