Detailed information of TA system TA057426

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/RelE-Phd
• Location: 1404996..1405540
• Replicon: chromosome
• Accession: NZ_CP012885
• Organism: Mycobacterium intracellulare subsp. chimaera strain AH16

Toxin (Protein)

• Gene name: relE
• Uniprot ID: A0A854HUL3
• Locus tag: AN480_RS07010
• Protein ID: WP_042910934.1
• Coordinates: 1405295..1405540 (+)
• Length: 82 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: S4Z4W6
• Locus tag: AN480_RS07005
• Protein ID: WP_020821851.1
• Coordinates: 1404996..1405280 (+)
• Length: 95 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
AN480_RS06980	1400070..1400669	-	600	WP_009953444.1	lipid droplet-associated protein	-
AN480_RS06985	1400759..1401757	+	999	WP_042910931.1	4-hydroxy-3-methylbut-2-enyl diphosphate reductase	-
AN480_RS06990	1401803..1402948	-	1146	WP_179945068.1	hypothetical protein	-
AN480_RS06995	1403078..1404151	+	1074	WP_042910932.1	redox-regulated ATPase YchF	-
AN480_RS07000	1404168..1404908	+	741	WP_042910933.1	aminoglycoside 3'-phosphotransferase	-
AN480_RS07005	1404996..1405280	+	285	WP_020821851.1	type II toxin-antitoxin system Phd/YefM family antitoxin	Antitoxin
AN480_RS07010	1405295..1405540	+	246	WP_042910934.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
AN480_RS07015	1405576..1406127	+	552	WP_036454798.1	VOC family protein	-
AN480_RS07020	1406206..1406604	+	399	WP_036454800.1	VOC family protein	-
AN480_RS07025	1406699..1406896	+	198	WP_036455532.1	type II toxin-antitoxin system VapB family antitoxin	-
AN480_RS07030	1406893..1407261	+	369	WP_036454801.1	type II toxin-antitoxin system VapC family toxin	-
AN480_RS07035	1407444..1407785	+	342	WP_172417493.1	hypothetical protein	-
AN480_RS31560	1407871..1408230	+	360	WP_042910935.1	hypothetical protein	-
AN480_RS31460	1408415..1408946	+	532	Protein_1381	C40 family peptidase	-
AN480_RS07050	1409353..1409676	+	324	WP_036454806.1	antibiotic biosynthesis monooxygenase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (29-80)

Antitoxin

• Type II toxin-antitoxin system, antitoxin Phd/YefM (1-71)

Sequences

Toxin

Protein

• Length: 82 a.a.
• Molecular weight: 9380.95 Da
• Isoelectric Point: 11.2612

>T57426 WP_042910934.1 NZ_CP012885:1405295-1405540 [Mycobacterium intracellulare subsp. chimaera]
MTAAAKRALTHLLPESVAIACWEFIRGPLAENPQRVGKPLRGQLEGRYSARRGEFRVIYRIFDERVVVPVIHIAHRRDVY
R

Nucleotide

• Length: 246 bp

>T57426 NZ_CP012885:1405295-1405540 [Mycobacterium intracellulare subsp. chimaera]
ATGACGGCAGCTGCGAAGAGGGCGCTCACTCATTTGTTGCCCGAGTCGGTGGCCATTGCTTGCTGGGAGTTCATTCGGGG
TCCGCTCGCGGAGAACCCGCAGCGGGTGGGCAAGCCGCTTCGCGGCCAGTTGGAAGGGCGATACTCGGCGCGCAGGGGCG
AGTTTCGCGTCATTTACCGGATCTTCGACGAACGGGTGGTGGTCCCCGTCATCCACATCGCGCATCGCCGCGACGTTTAC
CGGTGA

Antitoxin

Protein

• Length: 95 a.a.
• Molecular weight: 10513.88 Da
• Isoelectric Point: 4.3705

>AT57426 WP_020821851.1 NZ_CP012885:1404996-1405280 [Mycobacterium intracellulare subsp. chimaera]
MSTLPLAEVRANLSKLVDEAVRTHERIEVTRQGRRAAVILSADDFDSIMETLAILSDQDLMREVRAAESEAEDGALYTLD
QVTEEMRAVGRLPR

Nucleotide

• Length: 285 bp

>AT57426 NZ_CP012885:1404996-1405280 [Mycobacterium intracellulare subsp. chimaera]
ATGTCGACGCTTCCGCTGGCCGAGGTCCGAGCCAACCTTTCCAAGCTGGTCGACGAGGCCGTCCGGACCCATGAGCGCAT
CGAGGTCACCAGGCAAGGTCGCCGCGCGGCGGTGATTCTCAGCGCGGATGACTTCGATTCGATTATGGAAACTCTGGCCA
TCCTCAGCGATCAAGACTTGATGCGCGAAGTCCGAGCGGCAGAGTCAGAGGCAGAGGACGGCGCGCTCTACACACTCGAT
CAGGTGACCGAGGAGATGCGTGCTGTCGGCCGGCTCCCGCGGTGA

Structures

Toxin

• AlphaFold DB: A0A854HUL3

Antitoxin

• AlphaFold DB: S4Z4W6