Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 3832459..3833078 Replicon chromosome
Accession NZ_CP012883
Organism Klebsiella pneumoniae KP-1

Toxin (Protein)


Gene name Hha Uniprot ID R8WYV2
Locus tag KLP1_RS19015 Protein ID WP_002892050.1
Coordinates 3832459..3832677 (-) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID J2DPF6
Locus tag KLP1_RS19020 Protein ID WP_002892066.1
Coordinates 3832704..3833078 (-) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KLP1_RS18980 3828506..3828769 + 264 WP_002892011.1 type B 50S ribosomal protein L31 -
KLP1_RS18985 3828769..3828909 + 141 WP_002892018.1 type B 50S ribosomal protein L36 -
KLP1_RS18990 3828906..3829604 - 699 WP_002892021.1 GNAT family N-acetyltransferase -
KLP1_RS18995 3829705..3831156 + 1452 WP_002892023.1 PLP-dependent aminotransferase family protein -
KLP1_RS19000 3831131..3831601 - 471 WP_021441312.1 YlaC family protein -
KLP1_RS28915 3831622..3831762 + 141 WP_004147370.1 hypothetical protein -
KLP1_RS19010 3831734..3832300 - 567 WP_021441313.1 maltose O-acetyltransferase -
KLP1_RS19015 3832459..3832677 - 219 WP_002892050.1 hemolysin expression modulator Hha Toxin
KLP1_RS19020 3832704..3833078 - 375 WP_002892066.1 Hha toxicity modulator TomB Antitoxin
KLP1_RS19025 3833564..3836710 - 3147 WP_002892069.1 multidrug efflux RND transporter permease subunit AcrB -
KLP1_RS19030 3836733..3837926 - 1194 WP_004177236.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-116)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8628.00 Da        Isoelectric Point: 8.9008

>T57423 WP_002892050.1 NZ_CP012883:c3832677-3832459 [Klebsiella pneumoniae KP-1]
MSDKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPTSVWKFIR

Download         Length: 219 bp

>T57423 NZ_CP012883:c3832677-3832459 [Klebsiella pneumoniae KP-1]
ATGTCTGATAAGCCATTAACTAAAACAGACTATTTGATGCGCTTACGTCGTTGCCAGACAATTGACACGCTGGAGCGCGT
CATTGAAAAAAATAAATATGAACTGTCTGATAATGAGCTGGCGGTATTTTACTCAGCTGCCGACCATCGTCTGGCGGAAC
TGACCATGAATAAGCTATACGATAAAATCCCGACTTCTGTCTGGAAATTTATCCGCTAA

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14368.06 Da        Isoelectric Point: 4.8989

>AT57423 WP_002892066.1 NZ_CP012883:c3833078-3832704 [Klebsiella pneumoniae KP-1]
MDEYSPKRHDIAQLRFLCETLYHDCLANLEESNHGWVNDPTSAVNLQLNELIEHIATFALNYKIKYAEDNKLIAQVDEYL
DDTFTLFSNYGINSTDLQKWKKSGNRLFRCFVNASRENPASLSC

Download         Length: 375 bp

>AT57423 NZ_CP012883:c3833078-3832704 [Klebsiella pneumoniae KP-1]
ATGGACGAATACTCGCCAAAAAGACATGATATTGCACAGCTACGCTTTCTCTGCGAAACGCTGTATCATGACTGCCTTGC
AAACCTGGAAGAGAGCAACCATGGCTGGGTCAACGACCCGACGTCGGCTGTCAATCTCCAGTTAAATGAATTGATCGAGC
ACATTGCCACATTCGCTCTTAATTATAAAATTAAGTATGCAGAGGATAATAAGCTGATCGCTCAGGTTGACGAATATCTG
GACGACACTTTTACGTTGTTCAGTAACTACGGCATTAACTCTACGGATTTGCAAAAGTGGAAAAAATCCGGTAACCGACT
ATTTCGTTGCTTTGTCAACGCCAGCCGGGAAAACCCGGCCAGTCTATCGTGTTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2P8K6F2

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GJ93

References