Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 3101829..3102345 Replicon chromosome
Accession NZ_CP012883
Organism Klebsiella pneumoniae KP-1

Toxin (Protein)


Gene name relE Uniprot ID J2XDK6
Locus tag KLP1_RS15445 Protein ID WP_002886902.1
Coordinates 3102061..3102345 (+) Length 95 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID R4Y888
Locus tag KLP1_RS15440 Protein ID WP_002886901.1
Coordinates 3101829..3102071 (+) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KLP1_RS15425 3097857..3098597 + 741 WP_002886899.1 KDGP aldolase family protein -
KLP1_RS15430 3098664..3099818 + 1155 WP_002886900.1 lactonase family protein -
KLP1_RS15435 3099841..3101751 + 1911 WP_004152270.1 BglG family transcription antiterminator -
KLP1_RS15440 3101829..3102071 + 243 WP_002886901.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
KLP1_RS15445 3102061..3102345 + 285 WP_002886902.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
KLP1_RS15450 3102349..3102813 - 465 WP_004222151.1 anaerobic ribonucleoside-triphosphate reductase-activating protein -
KLP1_RS15455 3103121..3105259 - 2139 WP_004186701.1 anaerobic ribonucleoside-triphosphate reductase -
KLP1_RS15465 3105616..3106359 - 744 WP_021441079.1 MurR/RpiR family transcriptional regulator -
KLP1_RS28840 3106362..3106535 - 174 WP_032410138.1 hypothetical protein -
KLP1_RS15475 3106620..3106928 + 309 WP_004178377.1 PTS sugar transporter subunit IIB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-82)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-80)


Sequences

Toxin        


Download         Length: 95 a.a.        Molecular weight: 11125.95 Da        Isoelectric Point: 10.3787

>T57421 WP_002886902.1 NZ_CP012883:3102061-3102345 [Klebsiella pneumoniae KP-1]
MTYELEFDPRAWREWQKPGETVKKQFKNKLQQIVQNPRIESARLSDLPDCYKIKLKASGYRLVYQVRDSVVVVYVIAIGK
REKAAVYHQANKRL

Download         Length: 285 bp

>T57421 NZ_CP012883:3102061-3102345 [Klebsiella pneumoniae KP-1]
ATGACCTATGAACTGGAGTTTGATCCACGAGCCTGGCGCGAATGGCAGAAGCCTGGCGAGACGGTCAAAAAACAGTTCAA
AAATAAGCTCCAGCAGATTGTGCAGAATCCGCGAATTGAGTCGGCCAGGCTGAGCGATTTACCGGATTGCTACAAAATCA
AGCTTAAGGCGTCAGGTTATCGGTTGGTGTATCAAGTACGAGATAGTGTGGTGGTGGTTTACGTTATTGCCATTGGCAAA
AGAGAGAAAGCGGCCGTTTATCATCAGGCGAATAAACGGCTCTAA

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 9045.55 Da        Isoelectric Point: 6.3340

>AT57421 WP_002886901.1 NZ_CP012883:3101829-3102071 [Klebsiella pneumoniae KP-1]
MATLNVRLDDKLKKEAYAVLEKLDMTPTEAVRLLFQYIAENGRMPVKSMTISDGEAALLRTVRERLENPRPGVKVSLDDL

Download         Length: 243 bp

>AT57421 NZ_CP012883:3101829-3102071 [Klebsiella pneumoniae KP-1]
ATGGCCACGCTCAATGTTCGACTGGACGATAAACTCAAAAAAGAGGCTTATGCCGTGCTGGAGAAACTCGATATGACACC
AACGGAGGCGGTACGCCTGCTGTTTCAATACATTGCGGAAAATGGCCGCATGCCGGTGAAAAGTATGACCATCAGTGATG
GCGAAGCGGCGTTATTACGCACCGTTCGCGAACGGCTGGAAAACCCACGGCCGGGGGTTAAGGTGAGTCTGGATGACCTA
TGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H3GMH2

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GLP0

References