Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 1735898..1736555 Replicon chromosome
Accession NZ_CP012883
Organism Klebsiella pneumoniae KP-1

Toxin (Protein)


Gene name cptA Uniprot ID W8UCT0
Locus tag KLP1_RS08595 Protein ID WP_002916310.1
Coordinates 1735898..1736308 (-) Length 137 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID W8UQ37
Locus tag KLP1_RS08600 Protein ID WP_002916312.1
Coordinates 1736289..1736555 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KLP1_RS08575 1731898..1733631 - 1734 WP_004149758.1 single-stranded-DNA-specific exonuclease RecJ -
KLP1_RS08580 1733637..1734350 - 714 WP_004185548.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
KLP1_RS08585 1734373..1735269 - 897 WP_004144729.1 site-specific tyrosine recombinase XerD -
KLP1_RS08590 1735370..1735891 + 522 WP_004144730.1 flavodoxin FldB -
KLP1_RS08595 1735898..1736308 - 411 WP_002916310.1 protein YgfX Toxin
KLP1_RS08600 1736289..1736555 - 267 WP_002916312.1 FAD assembly factor SdhE Antitoxin
KLP1_RS08605 1736801..1737784 + 984 WP_004185555.1 tRNA-modifying protein YgfZ -
KLP1_RS08610 1737935..1738594 - 660 WP_002916317.1 hemolysin III family protein -
KLP1_RS08615 1738758..1739069 - 312 WP_004144734.1 N(4)-acetylcytidine aminohydrolase -
KLP1_RS08620 1739119..1739847 + 729 WP_002916321.1 MurR/RpiR family transcriptional regulator -
KLP1_RS08625 1739966..1741399 + 1434 WP_002916322.1 6-phospho-beta-glucosidase BglA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-132)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 137 a.a.        Molecular weight: 16049.85 Da        Isoelectric Point: 11.4778

>T57415 WP_002916310.1 NZ_CP012883:c1736308-1735898 [Klebsiella pneumoniae KP-1]
VVLWQSDLRISWRAQWFSLLLHGVVAALVLLVPWPLSYTPIWLLLLSLVVFDCVRSQRRIHARRGEIKLLTDSRLRWQNA
EWEILGTPWVINSGMLLRLRHVDTRRGQHLWLAADSMDAGEWRDLRRLVLQKPAQE

Download         Length: 411 bp

>T57415 NZ_CP012883:c1736308-1735898 [Klebsiella pneumoniae KP-1]
GTGGTCCTGTGGCAATCTGATCTCCGTATCTCCTGGCGCGCGCAGTGGTTTTCCCTGCTGCTTCACGGCGTGGTGGCGGC
CCTGGTGCTGTTGGTTCCCTGGCCGCTGAGCTATACCCCGATCTGGCTGCTGCTGCTGTCGCTGGTGGTCTTCGACTGCG
TGCGCAGCCAGCGGCGGATCCATGCCCGTCGCGGGGAGATAAAACTGCTCACCGATTCCCGTCTTCGCTGGCAAAACGCC
GAATGGGAAATCCTCGGGACGCCGTGGGTTATCAATAGCGGTATGCTGCTGCGTTTGCGCCATGTCGATACCCGGCGCGG
ACAGCATCTTTGGCTGGCGGCGGACAGCATGGACGCCGGAGAGTGGCGCGATCTGCGCCGGCTGGTGCTGCAAAAACCGG
CGCAGGAGTAA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10480.98 Da        Isoelectric Point: 5.1116

>AT57415 WP_002916312.1 NZ_CP012883:c1736555-1736289 [Klebsiella pneumoniae KP-1]
MDINNKARIHWACRRGMRELDISIMPFFEYEYDTLSDADKQLFIRLLENDDPDLFNWLMNHGKPADAELQRMVTLIQTRN
RERGPVAI

Download         Length: 267 bp

>AT57415 NZ_CP012883:c1736555-1736289 [Klebsiella pneumoniae KP-1]
ATGGACATTAACAATAAAGCACGTATCCACTGGGCATGCCGCCGCGGGATGCGCGAACTCGACATCTCCATCATGCCGTT
CTTTGAGTATGAGTATGATACCCTCAGCGACGCTGACAAACAGCTGTTCATTCGCCTGCTGGAAAATGACGATCCGGATC
TGTTCAACTGGCTGATGAACCACGGCAAACCGGCCGATGCGGAGCTGCAGCGGATGGTAACCTTAATTCAGACACGGAAT
CGGGAACGTGGTCCTGTGGCAATCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H3GSW7

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GY41

References