57405

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) sanaTA/AbiEii-DUF6088
Location 1432456..1433803 Replicon chromosome
Accession NZ_CP012882
Organism Vibrio vulnificus NBRC 15645 = ATCC 27562

Toxin (Protein)


Gene name sanaT Uniprot ID -
Locus tag AOT11_RS21875 Protein ID WP_017422918.1
Coordinates 1432456..1433397 (-) Length 314 a.a.

Antitoxin (Protein)


Gene name sanaA Uniprot ID A0A854GL31
Locus tag AOT11_RS21880 Protein ID WP_017422919.1
Coordinates 1433399..1433803 (-) Length 135 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
AOT11_RS21860 1430171..1430737 - 567 WP_017422914.1 hypothetical protein -
AOT11_RS21875 1432456..1433397 - 942 WP_017422918.1 nucleotidyl transferase AbiEii/AbiGii toxin family protein Toxin
AOT11_RS21880 1433399..1433803 - 405 WP_017422919.1 hypothetical protein Antitoxin
AOT11_RS21885 1434137..1435897 + 1761 WP_017422920.1 ABC transporter ATP-binding protein/permease -
AOT11_RS21890 1435950..1436714 - 765 WP_017422921.1 nucleotidyltransferase domain-containing protein -
AOT11_RS23510 1437033..1437227 + 195 WP_127891366.1 hypothetical protein -
AOT11_RS21895 1437214..1437960 - 747 WP_026050861.1 carbon-nitrogen hydrolase family protein -
AOT11_RS21900 1438150..1438608 - 459 WP_011081157.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Nucleotidyl transferase AbiEii toxin, Type IV TA system

(33-300)

Antitoxin

Protein of unknown function DUF6088

(7-130)


Sequences

Toxin        


Download         Length: 314 a.a.        Molecular weight: 36018.40 Da        Isoelectric Point: 5.3175

>T57405 WP_017422918.1 NZ_CP012882:c1433397-1432456 [Vibrio vulnificus NBRC 15645 = ATCC 27562]
MNTLKQKFLEVSDALELGNPAIIEKDFWVVALLAELAKVSPEYHQMVFSGGTALAKSNVKILRMSEDVDIKLIPNQAFDE
LSRAKKKAVRKAWVNEIEQAITHSERFTVETRAVRDEYRYVEFELRYPQQFSQAPCLRPIIKLELIETIPLLDVESRSIQ
SLVAELYQQPHEVSSFDCVSVYATLVEKIISMLRRTMSVKRNTERTDDVALVRHIYDVHCITKLSTTELNSIDGLFKAVL
EEDIARFGNQNAEFVANPKQELQLGLKELEENPIFRQRFQDFVTPMVFNTEPHDFDTCFASFKRIAASLIEKI

Download         Length: 942 bp

>T57405 NZ_CP012882:c1433397-1432456 [Vibrio vulnificus NBRC 15645 = ATCC 27562]
ATGAACACACTGAAACAGAAATTCCTTGAGGTTTCCGACGCGCTTGAGCTCGGAAACCCTGCCATCATTGAAAAAGATTT
CTGGGTCGTTGCCTTACTTGCCGAGCTAGCAAAAGTTTCTCCTGAATATCATCAAATGGTCTTTTCCGGCGGTACGGCCT
TGGCGAAATCAAACGTTAAAATTCTAAGAATGTCGGAAGATGTGGATATAAAACTCATCCCCAACCAAGCGTTTGATGAA
CTGAGTCGTGCAAAAAAGAAAGCCGTTAGAAAGGCATGGGTTAACGAGATTGAACAGGCGATCACTCATTCAGAACGATT
TACCGTTGAAACGCGAGCTGTGCGAGATGAGTACCGTTACGTTGAGTTTGAACTCAGATATCCGCAACAGTTTAGTCAAG
CGCCCTGTCTTCGTCCCATTATTAAGTTAGAGTTAATCGAAACTATTCCATTACTGGATGTGGAGTCGCGCAGCATTCAA
TCACTGGTTGCAGAGTTGTACCAACAACCGCACGAAGTGAGTTCATTTGATTGCGTCTCTGTCTATGCCACATTGGTTGA
AAAAATTATTTCGATGCTGCGCCGTACCATGTCGGTAAAACGCAATACGGAGCGAACCGATGATGTTGCTTTGGTTCGCC
ATATCTACGATGTGCATTGCATAACAAAGCTCTCAACGACTGAACTCAACTCGATTGACGGCCTATTCAAAGCGGTACTG
GAAGAAGATATTGCCCGCTTTGGCAATCAAAATGCAGAGTTTGTTGCCAACCCCAAACAAGAGCTACAACTTGGCCTCAA
AGAACTTGAGGAAAATCCCATTTTCCGCCAACGCTTTCAGGACTTTGTCACGCCAATGGTGTTTAACACCGAGCCCCATG
ATTTTGATACCTGTTTTGCCTCATTCAAGCGCATTGCCGCGTCGCTAATTGAAAAAATTTAA

Antitoxin


Download         Length: 135 a.a.        Molecular weight: 15115.43 Da        Isoelectric Point: 10.6258

>AT57405 WP_017422919.1 NZ_CP012882:c1433803-1433399 [Vibrio vulnificus NBRC 15645 = ATCC 27562]
MTAVDRICQKIKRSRRYVFERKDFDGFASYDQIGRALRQLVQQGELMKLGYGLYTKARINSLTGKPMPTNPGGTDALVRE
ILKMKGVDFEMDSLSQQSLSGASTQIPSSVHYSWNPKQFNRKLVVGSRVLNLPS

Download         Length: 405 bp

>AT57405 NZ_CP012882:c1433803-1433399 [Vibrio vulnificus NBRC 15645 = ATCC 27562]
ATGACAGCAGTAGACCGCATTTGTCAAAAGATAAAGCGTTCAAGACGTTATGTATTTGAACGCAAAGACTTTGACGGATT
TGCAAGTTACGACCAAATAGGGCGGGCACTGAGGCAGCTTGTACAGCAAGGGGAGCTAATGAAGCTTGGCTATGGTTTGT
ATACCAAAGCAAGAATCAATAGCCTCACTGGTAAGCCTATGCCCACCAATCCAGGTGGTACCGATGCTCTTGTGCGTGAA
ATTCTTAAAATGAAAGGCGTTGATTTTGAAATGGATAGTCTATCGCAACAAAGTCTTTCAGGTGCGAGTACCCAAATTCC
ATCCTCTGTTCACTATTCATGGAACCCAAAACAGTTTAATCGCAAACTGGTGGTTGGTAGCCGTGTGCTGAACTTGCCAA
GTTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A854GL31

References