Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 3740334..3740991 Replicon chromosome
Accession NZ_CP012871
Organism [Enterobacter] lignolyticus strain G5

Toxin (Protein)


Gene name cptA Uniprot ID A0A806X7B2
Locus tag AO703_RS17335 Protein ID WP_062741885.1
Coordinates 3740334..3740744 (-) Length 137 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID E3G4Y1
Locus tag AO703_RS17340 Protein ID WP_013364882.1
Coordinates 3740725..3740991 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
AO703_RS17315 3736334..3738067 - 1734 WP_062741879.1 single-stranded-DNA-specific exonuclease RecJ -
AO703_RS17320 3738073..3738786 - 714 WP_013364886.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
AO703_RS17325 3738809..3739705 - 897 WP_062741881.1 site-specific tyrosine recombinase XerD -
AO703_RS17330 3739805..3740326 + 522 WP_062741883.1 flavodoxin FldB -
AO703_RS17335 3740334..3740744 - 411 WP_062741885.1 protein YgfX Toxin
AO703_RS17340 3740725..3740991 - 267 WP_013364882.1 FAD assembly factor SdhE Antitoxin
AO703_RS17345 3741239..3742222 + 984 WP_062741887.1 tRNA-modifying protein YgfZ -
AO703_RS17350 3742264..3742923 - 660 WP_013364880.1 hemolysin III family protein -
AO703_RS17355 3743087..3743398 - 312 WP_013364879.1 N(4)-acetylcytidine aminohydrolase -
AO703_RS17360 3743450..3744181 + 732 WP_062742512.1 MurR/RpiR family transcriptional regulator -
AO703_RS17365 3744299..3745732 + 1434 WP_062741889.1 6-phospho-beta-glucosidase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-132)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 137 a.a.        Molecular weight: 16065.93 Da        Isoelectric Point: 11.7657

>T57391 WP_062741885.1 NZ_CP012871:c3740744-3740334 [[Enterobacter] lignolyticus]
VVLWQSDLRVSWRAQWVSLLLHGLVAAAILLMPWPLSYTPLWLVLLSLVVFDSVRSQRRINARQGEIKLLMDSRLRWHNQ
EWEIIGTPWIIKSGMMLRLRRIGSYKRIHLWIAADSMDAGEWRDLRRTISQQPAQQ

Download         Length: 411 bp

>T57391 NZ_CP012871:c3740744-3740334 [[Enterobacter] lignolyticus]
GTGGTCCTGTGGCAATCTGATCTTCGCGTCTCCTGGCGCGCTCAGTGGGTGTCTCTGCTGCTCCACGGCCTGGTGGCGGC
GGCGATATTGCTGATGCCCTGGCCGCTGAGCTACACCCCGCTCTGGCTGGTGCTCCTGTCGCTGGTGGTGTTCGACAGCG
TTCGCAGCCAGCGCCGCATCAACGCCCGTCAGGGGGAAATCAAGCTGCTGATGGATTCCCGCCTGCGCTGGCATAACCAG
GAGTGGGAAATTATTGGCACCCCCTGGATCATCAAAAGTGGGATGATGCTGCGCTTACGCAGAATCGGAAGCTACAAGAG
AATACACCTGTGGATTGCGGCTGACAGCATGGATGCCGGAGAGTGGCGGGATTTGCGCCGGACGATATCGCAGCAGCCGG
CGCAGCAGTAG

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10500.04 Da        Isoelectric Point: 5.1114

>AT57391 WP_013364882.1 NZ_CP012871:c3740991-3740725 [[Enterobacter] lignolyticus]
MDITNKARIHWACRRGMRELDISIMPFFEYEYDTLSDSDKQLFIRLLECDDPDLFNWLMNHGKPADAELQRMVQLIQTRN
RERGPVAI

Download         Length: 267 bp

>AT57391 NZ_CP012871:c3740991-3740725 [[Enterobacter] lignolyticus]
ATGGACATTACTAATAAAGCCCGTATCCATTGGGCATGCCGCCGCGGTATGCGTGAGCTCGATATTTCCATCATGCCGTT
CTTTGAATATGAATACGACACGTTGAGCGACAGCGATAAGCAGCTCTTTATTCGCCTTCTGGAGTGCGACGACCCCGATC
TTTTCAACTGGCTGATGAACCACGGGAAGCCAGCGGACGCGGAACTGCAAAGGATGGTGCAACTCATTCAGACACGGAAT
CGGGAACGTGGTCCTGTGGCAATCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A806X7B2

Antitoxin

Source ID Structure
AlphaFold DB A0A806XG21

References