Detailed information of TA system TA057390

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hicAB/-
• Location: 3012927..3013558
• Replicon: chromosome
• Accession: NZ_CP012871
• Organism: [Enterobacter] lignolyticus strain G5

Toxin (Protein)

• Gene name: hicA
• Uniprot ID: -
• Locus tag: AO703_RS22395
• Protein ID: WP_071886733.1
• Coordinates: 3013283..3013558 (-)
• Length: 92 a.a.

Antitoxin (Protein)

• Gene name: hicB
• Uniprot ID: E3GCU1
• Locus tag: AO703_RS13945
• Protein ID: WP_013365615.1
• Coordinates: 3012927..3013286 (-)
• Length: 120 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
AO703_RS13930	3009074..3010477	+	1404	WP_013365620.1	two-component system sensor histidine kinase BaeS	-
AO703_RS13935	3010474..3011196	+	723	WP_013365619.1	two-component system response regulator BaeR	-
AO703_RS13940	3011347..3012708	+	1362	WP_013365618.1	tRNA 5-hydroxyuridine modification protein YegQ	-
AO703_RS13945	3012927..3013286	-	360	WP_013365615.1	type II toxin-antitoxin system HicB family antitoxin	Antitoxin
AO703_RS22395	3013283..3013558	-	276	WP_071886733.1	type II toxin-antitoxin system HicA family toxin	Toxin
AO703_RS13950	3013685..3014155	-	471	WP_071886734.1	hypothetical protein	-
AO703_RS13955	3014142..3014909	-	768	WP_062741511.1	winged helix-turn-helix domain-containing protein	-
AO703_RS13960	3014965..3015657	-	693	WP_062741512.1	fimbria/pilus periplasmic chaperone	-
AO703_RS13965	3015629..3016972	-	1344	WP_062741513.1	fimbrial protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HicA mRNA interferase family (30-86)

Antitoxin

• Uncharacterised protein family HicB (60-112)

Sequences

Toxin

Protein

• Length: 92 a.a.
• Molecular weight: 10061.62 Da
• Isoelectric Point: 10.6115

>T57390 WP_071886733.1 NZ_CP012871:c3013558-3013283 [[Enterobacter] lignolyticus]
MKERVSLLRKKQKSTLEQIFKSPAQSGIKWADIESMIKALGGEVKEGRGSRCIFLLNGSIASFHRPHPSPDTDKGAVANL
RDWLESTGVKP

Nucleotide

• Length: 276 bp

>T57390 NZ_CP012871:c3013558-3013283 [[Enterobacter] lignolyticus]
ATGAAAGAGCGCGTTTCATTACTACGGAAGAAACAAAAAAGTACGCTGGAACAAATATTTAAATCACCCGCTCAATCTGG
CATTAAGTGGGCTGATATAGAATCCATGATCAAGGCCTTAGGCGGTGAGGTTAAAGAAGGTCGAGGTTCACGCTGCATAT
TTCTGCTGAACGGTAGTATTGCCAGCTTCCATCGACCTCATCCATCACCGGATACCGATAAAGGCGCAGTAGCCAACCTG
CGTGACTGGCTGGAGAGTACAGGAGTAAAGCCATGA

Antitoxin

Protein

• Length: 120 a.a.
• Molecular weight: 13207.91 Da
• Isoelectric Point: 5.2080

>AT57390 WP_013365615.1 NZ_CP012871:c3013286-3012927 [[Enterobacter] lignolyticus]
MSKASTPNTIEIAGQPAVISYVPELGAFRGKFLGLTGYCDFVSDSIQGLKKEGEISLREYLDDCKAAGIEAYTHQEKIKT
FTLRYPESFGERLTQAAAEHETSVNAYIIETLNERMKHA

Nucleotide

• Length: 360 bp

>AT57390 NZ_CP012871:c3013286-3012927 [[Enterobacter] lignolyticus]
ATGAGCAAGGCATCAACGCCAAACACGATTGAGATAGCGGGGCAGCCTGCAGTGATTAGCTATGTTCCAGAACTTGGCGC
TTTTCGCGGTAAGTTCCTCGGCCTGACGGGATATTGCGACTTCGTCTCCGACAGTATCCAGGGTCTGAAAAAAGAAGGTG
AGATCTCACTGCGCGAGTACCTTGATGATTGTAAAGCAGCAGGTATTGAGGCCTACACGCATCAGGAGAAAATTAAAACC
TTCACGCTACGTTATCCAGAATCATTTGGAGAGCGTTTAACCCAGGCCGCCGCGGAGCACGAAACGTCGGTAAATGCTTA
TATCATTGAAACGCTCAATGAACGTATGAAGCATGCGTGA

Structures

Antitoxin

• AlphaFold DB: A0A806X756