Detailed information of TA system
Bioinformatically predictedOverview
TA module
Type | II | Classification (family/domain) | Hha-TomB/- |
Location | 1177669..1178288 | Replicon | chromosome |
Accession | NZ_CP012871 | ||
Organism | [Enterobacter] lignolyticus strain G5 |
Toxin (Protein)
Gene name | Hha | Uniprot ID | E3G6B6 |
Locus tag | AO703_RS22085 | Protein ID | WP_013367304.1 |
Coordinates | 1177669..1177887 (-) | Length | 73 a.a. |
Antitoxin (Protein)
Gene name | TomB | Uniprot ID | E3G6B5 |
Locus tag | AO703_RS05365 | Protein ID | WP_013367303.1 |
Coordinates | 1177914..1178288 (-) | Length | 125 a.a. |
Genomic Context
Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
---|---|---|---|---|---|---|
AO703_RS05335 | 1173751..1174011 | + | 261 | WP_013367310.1 | type B 50S ribosomal protein L31 | - |
AO703_RS05340 | 1174014..1174154 | + | 141 | WP_006818844.1 | type B 50S ribosomal protein L36 | - |
AO703_RS05345 | 1174151..1174861 | - | 711 | WP_062740502.1 | GNAT family N-acetyltransferase | - |
AO703_RS05350 | 1174962..1176422 | + | 1461 | WP_062740503.1 | PLP-dependent aminotransferase family protein | - |
AO703_RS05355 | 1176394..1176861 | - | 468 | WP_062740504.1 | hypothetical protein | - |
AO703_RS05360 | 1176961..1177515 | - | 555 | WP_062740505.1 | maltose O-acetyltransferase | - |
AO703_RS22085 | 1177669..1177887 | - | 219 | WP_013367304.1 | hemolysin expression modulator Hha | Toxin |
AO703_RS05365 | 1177914..1178288 | - | 375 | WP_013367303.1 | Hha toxicity modulator TomB | Antitoxin |
AO703_RS05370 | 1178767..1181913 | - | 3147 | WP_062740506.1 | multidrug efflux RND transporter permease subunit AcrB | - |
AO703_RS05375 | 1181936..1183129 | - | 1194 | WP_062740507.1 | multidrug efflux RND transporter periplasmic adaptor subunit AcrA | - |
Associated MGEs
MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 73 a.a. Molecular weight: 8640.05 Da Isoelectric Point: 8.9008
>T57379 WP_013367304.1 NZ_CP012871:c1177887-1177669 [[Enterobacter] lignolyticus]
MSEKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPVSVWKFIR
MSEKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPVSVWKFIR
Download Length: 219 bp
>T57379 NZ_CP012871:c1177887-1177669 [[Enterobacter] lignolyticus]
ATGTCAGAGAAACCCTTAACAAAGACTGATTATTTGATGCGTTTGCGACGTTGTCAGACTATTGACACGCTGGAACGTGT
CATTGAAAAAAATAAATATGAACTTTCAGACAATGAACTGGCTGTTTTTTACTCAGCCGCCGATCATCGTCTTGCCGAAC
TTACTATGAATAAGCTTTACGATAAAATCCCCGTTTCGGTATGGAAATTCATACGTTAA
ATGTCAGAGAAACCCTTAACAAAGACTGATTATTTGATGCGTTTGCGACGTTGTCAGACTATTGACACGCTGGAACGTGT
CATTGAAAAAAATAAATATGAACTTTCAGACAATGAACTGGCTGTTTTTTACTCAGCCGCCGATCATCGTCTTGCCGAAC
TTACTATGAATAAGCTTTACGATAAAATCCCCGTTTCGGTATGGAAATTCATACGTTAA
Antitoxin
Download Length: 125 a.a. Molecular weight: 14526.41 Da Isoelectric Point: 4.9045
>AT57379 WP_013367303.1 NZ_CP012871:c1178288-1177914 [[Enterobacter] lignolyticus]
MDEYSPKRHDIAQLKFLCETLYHDCLVNLEENRAGWVNDPTSAINLQINELIEHIATFALNYKIKYNEDNKLIAQIDEYL
DDTFMLFSNYGINAEDLQKWRKSGNRLFRCFTNISRANPVSLSC
MDEYSPKRHDIAQLKFLCETLYHDCLVNLEENRAGWVNDPTSAINLQINELIEHIATFALNYKIKYNEDNKLIAQIDEYL
DDTFMLFSNYGINAEDLQKWRKSGNRLFRCFTNISRANPVSLSC
Download Length: 375 bp
>AT57379 NZ_CP012871:c1178288-1177914 [[Enterobacter] lignolyticus]
ATGGACGAATACTCGCCAAAAAGACATGATATCGCACAGCTTAAATTTCTCTGTGAAACCCTGTATCATGACTGCCTTGT
TAACCTTGAAGAGAACCGTGCAGGCTGGGTGAACGATCCGACCTCCGCGATTAACCTTCAAATCAACGAACTGATCGAGC
ATATTGCTACCTTCGCACTTAATTACAAAATTAAGTATAACGAAGACAATAAATTGATCGCACAAATTGATGAATATCTG
GACGATACCTTTATGTTGTTCAGTAACTATGGCATTAACGCAGAGGATCTGCAGAAATGGCGAAAATCTGGAAACAGGCT
TTTTCGTTGTTTCACCAACATCAGTAGAGCTAATCCGGTTAGTCTCTCCTGTTAA
ATGGACGAATACTCGCCAAAAAGACATGATATCGCACAGCTTAAATTTCTCTGTGAAACCCTGTATCATGACTGCCTTGT
TAACCTTGAAGAGAACCGTGCAGGCTGGGTGAACGATCCGACCTCCGCGATTAACCTTCAAATCAACGAACTGATCGAGC
ATATTGCTACCTTCGCACTTAATTACAAAATTAAGTATAACGAAGACAATAAATTGATCGCACAAATTGATGAATATCTG
GACGATACCTTTATGTTGTTCAGTAACTATGGCATTAACGCAGAGGATCTGCAGAAATGGCGAAAATCTGGAAACAGGCT
TTTTCGTTGTTTCACCAACATCAGTAGAGCTAATCCGGTTAGTCTCTCCTGTTAA
Similar Proteins
Only experimentally validated proteins are listed.
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
---|
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
---|
Structures
Toxin
Source | ID | Structure |
---|---|---|
AlphaFold DB | E3G6B6 |
Antitoxin
Source | ID | Structure |
---|---|---|
AlphaFold DB | A0A806X2P6 |