57379

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 1177669..1178288 Replicon chromosome
Accession NZ_CP012871
Organism [Enterobacter] lignolyticus strain G5

Toxin (Protein)


Gene name Hha Uniprot ID E3G6B6
Locus tag AO703_RS22085 Protein ID WP_013367304.1
Coordinates 1177669..1177887 (-) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID E3G6B5
Locus tag AO703_RS05365 Protein ID WP_013367303.1
Coordinates 1177914..1178288 (-) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
AO703_RS05335 1173751..1174011 + 261 WP_013367310.1 type B 50S ribosomal protein L31 -
AO703_RS05340 1174014..1174154 + 141 WP_006818844.1 type B 50S ribosomal protein L36 -
AO703_RS05345 1174151..1174861 - 711 WP_062740502.1 GNAT family N-acetyltransferase -
AO703_RS05350 1174962..1176422 + 1461 WP_062740503.1 PLP-dependent aminotransferase family protein -
AO703_RS05355 1176394..1176861 - 468 WP_062740504.1 hypothetical protein -
AO703_RS05360 1176961..1177515 - 555 WP_062740505.1 maltose O-acetyltransferase -
AO703_RS22085 1177669..1177887 - 219 WP_013367304.1 hemolysin expression modulator Hha Toxin
AO703_RS05365 1177914..1178288 - 375 WP_013367303.1 Hha toxicity modulator TomB Antitoxin
AO703_RS05370 1178767..1181913 - 3147 WP_062740506.1 multidrug efflux RND transporter permease subunit AcrB -
AO703_RS05375 1181936..1183129 - 1194 WP_062740507.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-114)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8640.05 Da        Isoelectric Point: 8.9008

>T57379 WP_013367304.1 NZ_CP012871:c1177887-1177669 [[Enterobacter] lignolyticus]
MSEKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPVSVWKFIR

Download         Length: 219 bp

>T57379 NZ_CP012871:c1177887-1177669 [[Enterobacter] lignolyticus]
ATGTCAGAGAAACCCTTAACAAAGACTGATTATTTGATGCGTTTGCGACGTTGTCAGACTATTGACACGCTGGAACGTGT
CATTGAAAAAAATAAATATGAACTTTCAGACAATGAACTGGCTGTTTTTTACTCAGCCGCCGATCATCGTCTTGCCGAAC
TTACTATGAATAAGCTTTACGATAAAATCCCCGTTTCGGTATGGAAATTCATACGTTAA

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14526.41 Da        Isoelectric Point: 4.9045

>AT57379 WP_013367303.1 NZ_CP012871:c1178288-1177914 [[Enterobacter] lignolyticus]
MDEYSPKRHDIAQLKFLCETLYHDCLVNLEENRAGWVNDPTSAINLQINELIEHIATFALNYKIKYNEDNKLIAQIDEYL
DDTFMLFSNYGINAEDLQKWRKSGNRLFRCFTNISRANPVSLSC

Download         Length: 375 bp

>AT57379 NZ_CP012871:c1178288-1177914 [[Enterobacter] lignolyticus]
ATGGACGAATACTCGCCAAAAAGACATGATATCGCACAGCTTAAATTTCTCTGTGAAACCCTGTATCATGACTGCCTTGT
TAACCTTGAAGAGAACCGTGCAGGCTGGGTGAACGATCCGACCTCCGCGATTAACCTTCAAATCAACGAACTGATCGAGC
ATATTGCTACCTTCGCACTTAATTACAAAATTAAGTATAACGAAGACAATAAATTGATCGCACAAATTGATGAATATCTG
GACGATACCTTTATGTTGTTCAGTAACTATGGCATTAACGCAGAGGATCTGCAGAAATGGCGAAAATCTGGAAACAGGCT
TTTTCGTTGTTTCACCAACATCAGTAGAGCTAATCCGGTTAGTCTCTCCTGTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB E3G6B6

Antitoxin

Source ID Structure
AlphaFold DB A0A806X2P6

References