Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) shpAB/BrnT-BrnA
Location 646117..646693 Replicon chromosome
Accession NZ_CP012871
Organism [Enterobacter] lignolyticus strain G5

Toxin (Protein)


Gene name shpA Uniprot ID A0A806X2H5
Locus tag AO703_RS02995 Protein ID WP_062740282.1
Coordinates 646117..646404 (+) Length 96 a.a.

Antitoxin (Protein)


Gene name shpB Uniprot ID A0A806X9D9
Locus tag AO703_RS03000 Protein ID WP_062740283.1
Coordinates 646391..646693 (+) Length 101 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
AO703_RS02975 641642..643243 + 1602 WP_013367751.1 APC family permease -
AO703_RS02980 643258..644277 + 1020 WP_062740279.1 Ldh family oxidoreductase -
AO703_RS02985 644258..644503 - 246 Protein_568 LysR family transcriptional regulator -
AO703_RS02990 644588..645946 + 1359 WP_062740281.1 esterase-like activity of phytase family protein -
AO703_RS02995 646117..646404 + 288 WP_062740282.1 BrnT family toxin Toxin
AO703_RS03000 646391..646693 + 303 WP_062740283.1 BrnA antitoxin family protein Antitoxin
AO703_RS03005 646770..647723 - 954 WP_062740284.1 GTPase -
AO703_RS03010 647734..647937 - 204 WP_003856610.1 YbdD/YjiX family protein -
AO703_RS03015 648034..650187 - 2154 WP_062740285.1 carbon starvation protein A -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Ribonuclease toxin, BrnT, of type II toxin-antitoxin system

(7-88)

Antitoxin

BrnA antitoxin of type II toxin-antitoxin system

(38-93)


Sequences

Toxin        


Download         Length: 96 a.a.        Molecular weight: 11356.77 Da        Isoelectric Point: 7.5726

>T57378 WP_062740282.1 NZ_CP012871:646117-646404 [[Enterobacter] lignolyticus]
MPTEFEWDTNKAKRNLHKHGVRFEDAVLVFDDPRHLSRQDRYENGEHRWQTIGLVHGLVIILVAHAIRFESGDEIIRIIS
ARKADRKERNRYEHD

Download         Length: 288 bp

>T57378 NZ_CP012871:646117-646404 [[Enterobacter] lignolyticus]
ATGCCAACGGAGTTCGAGTGGGATACCAACAAGGCGAAACGCAATCTGCACAAACATGGCGTCCGGTTTGAAGATGCGGT
TTTGGTTTTCGACGATCCCCGCCACTTATCGCGGCAGGATCGCTATGAAAATGGCGAGCACCGCTGGCAAACTATTGGGC
TTGTGCATGGCCTGGTCATTATCCTGGTTGCACACGCGATTCGTTTCGAAAGTGGCGACGAAATTATCAGAATCATCAGC
GCCCGGAAGGCCGATCGCAAAGAGAGGAACCGTTATGAGCACGATTAA

Antitoxin


Download         Length: 101 a.a.        Molecular weight: 11302.90 Da        Isoelectric Point: 10.2493

>AT57378 WP_062740283.1 NZ_CP012871:646391-646693 [[Enterobacter] lignolyticus]
MSTIKHKRGGATVLSAQQEAELKALADKPDASIDYSDIPATDDAQWTEAVRGKFYRPLKTQASVRIDADVMEWLKRPGKG
YQTRLNAILREAMLRDRNKK

Download         Length: 303 bp

>AT57378 NZ_CP012871:646391-646693 [[Enterobacter] lignolyticus]
ATGAGCACGATTAAACATAAGCGCGGTGGTGCAACCGTGCTGAGTGCGCAGCAGGAGGCGGAATTAAAAGCTCTGGCGGA
CAAACCCGACGCGAGCATTGATTACAGCGATATTCCCGCAACGGATGATGCGCAGTGGACGGAAGCCGTGCGGGGGAAGT
TTTATCGGCCATTAAAGACGCAGGCCTCAGTACGTATTGATGCCGACGTGATGGAATGGCTGAAACGGCCTGGAAAAGGT
TATCAGACGCGCCTGAACGCAATTTTGCGTGAGGCGATGCTGCGGGATCGGAATAAAAAATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A806X2H5

Antitoxin

Source ID Structure
AlphaFold DB A0A806X9D9

References