Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) parDE/RHH(antitoxin)
Location 1335013..1335553 Replicon chromosome
Accession NZ_CP012836
Organism Algoriphagus sanaruensis strain M8-2 isolate Brackish lake

Toxin (Protein)


Gene name parE Uniprot ID A0A142ELE2
Locus tag AO498_RS05950 Protein ID WP_067544728.1
Coordinates 1335013..1335318 (-) Length 102 a.a.

Antitoxin (Protein)


Gene name parD Uniprot ID A0A142ELE3
Locus tag AO498_RS05955 Protein ID WP_067544730.1
Coordinates 1335305..1335553 (-) Length 83 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
AO498_RS05940 1330322..1332775 - 2454 WP_082792286.1 DUF1549 domain-containing protein -
AO498_RS05945 1332958..1335024 + 2067 WP_067544727.1 glycoside hydrolase family 97 protein -
AO498_RS05950 1335013..1335318 - 306 WP_067544728.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
AO498_RS05955 1335305..1335553 - 249 WP_067544730.1 type II toxin-antitoxin system ParD family antitoxin Antitoxin
AO498_RS05960 1335612..1337744 - 2133 WP_102135908.1 alpha-galactosidase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(9-94)

Antitoxin

Antitoxin ParD

(1-81)


Sequences

Toxin        


Download         Length: 102 a.a.        Molecular weight: 12183.90 Da        Isoelectric Point: 6.0699

>T57283 WP_067544728.1 NZ_CP012836:c1335318-1335013 [Algoriphagus sanaruensis]
MPKYDFLISIKAKEDLQRIWEYTFENWSENQADDYYLSIVNKIEQICDHPFSGIDCDFIRAGYRKAWIKSHVIFYRLASN
HTIEIIRILHQKQDVNPDLFL

Download         Length: 306 bp

>T57283 NZ_CP012836:c1335318-1335013 [Algoriphagus sanaruensis]
ATGCCAAAGTATGATTTTTTAATCTCGATAAAAGCTAAGGAAGACTTACAACGGATTTGGGAATACACTTTTGAAAACTG
GTCTGAAAATCAAGCCGATGACTATTATTTAAGCATTGTCAATAAAATCGAACAGATTTGCGATCATCCCTTCTCTGGAA
TAGACTGTGATTTCATCAGGGCAGGATATCGAAAAGCATGGATCAAATCTCATGTGATTTTTTATCGCCTTGCTTCCAAT
CATACGATTGAAATCATCAGAATTCTACACCAGAAACAAGATGTTAACCCCGATTTATTCTTGTGA

Antitoxin


Download         Length: 83 a.a.        Molecular weight: 9210.43 Da        Isoelectric Point: 6.7289

>AT57283 WP_067544730.1 NZ_CP012836:c1335553-1335305 [Algoriphagus sanaruensis]
MGKNTSISLGDHFEDFVEKEVSSGRYSTASEVIRAGLRLLEKEKLKLEILREALAEGEKSGFDPNFDSHSFLESLKKKHA
KV

Download         Length: 249 bp

>AT57283 NZ_CP012836:c1335553-1335305 [Algoriphagus sanaruensis]
ATGGGAAAGAATACATCTATTTCGTTGGGAGATCATTTTGAGGATTTTGTTGAAAAAGAAGTTTCTTCAGGCAGGTACAG
TACTGCCAGTGAAGTGATTAGAGCTGGATTACGTTTACTTGAGAAGGAAAAATTGAAGCTTGAAATTTTACGCGAGGCCC
TGGCAGAAGGGGAAAAAAGTGGATTCGACCCTAATTTCGATTCTCATTCATTTTTAGAATCCTTAAAAAAGAAACATGCC
AAAGTATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A142ELE2

Antitoxin

Source ID Structure
AlphaFold DB A0A142ELE3

References