Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) parDE/RelE-RHH
Location 15443..15990 Replicon plasmid pCFSAN001588_002
Accession NZ_CP012835
Organism Salmonella enterica subsp. enterica serovar Cerro str. CFSAN001588

Toxin (Protein)


Gene name parE Uniprot ID E9LLH3
Locus tag CFSAN001588_RS22820 Protein ID WP_000969996.1
Coordinates 15709..15990 (+) Length 94 a.a.

Antitoxin (Protein)


Gene name parD Uniprot ID A0A7U8WKC6
Locus tag CFSAN001588_RS22815 Protein ID WP_000079946.1
Coordinates 15443..15712 (+) Length 90 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CFSAN001588_RS22795 11085..11618 - 534 WP_023233600.1 hypothetical protein -
CFSAN001588_RS22800 12060..12347 - 288 WP_000074849.1 conjugal transfer protein TraA -
CFSAN001588_RS24585 12265..12528 - 264 WP_001324596.1 ash family protein -
CFSAN001588_RS22810 13501..14532 + 1032 WP_000907873.1 replication initiation protein -
CFSAN001588_RS22815 15443..15712 + 270 WP_000079946.1 hypothetical protein Antitoxin
CFSAN001588_RS22820 15709..15990 + 282 WP_000969996.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
CFSAN001588_RS22825 16036..16884 + 849 WP_023166900.1 3'-5' exonuclease -
CFSAN001588_RS22830 17000..17482 + 483 WP_023166899.1 hypothetical protein -
CFSAN001588_RS22835 17900..19426 + 1527 WP_023893442.1 Tar ligand binding domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Conjugative plasmid - - 1..62884 62884


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(4-92)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 94 a.a.        Molecular weight: 10893.57 Da        Isoelectric Point: 8.4615

>T57278 WP_000969996.1 NZ_CP012835:15709-15990 [Salmonella enterica subsp. enterica serovar Cerro str. CFSAN001588]
MMEIFWTMLASQDRKRIREYIAEQNLMAAIELDERIGYSASSLAGQPYKGRNGRVEGTRELVIHPHFVLVYEVDSQWGKV
YILRVLHTAQKWP

Download         Length: 282 bp

>T57278 NZ_CP012835:15709-15990 [Salmonella enterica subsp. enterica serovar Cerro str. CFSAN001588]
ATGATGGAGATATTCTGGACCATGCTGGCCAGCCAGGACAGGAAGCGCATTCGTGAGTACATTGCGGAGCAGAACCTGAT
GGCTGCCATTGAACTGGACGAACGGATTGGTTATTCAGCCAGCAGCCTGGCCGGGCAGCCGTATAAAGGCCGCAACGGTC
GTGTGGAAGGTACCCGGGAACTGGTTATTCACCCGCATTTTGTTCTGGTTTATGAGGTCGACAGCCAGTGGGGAAAAGTG
TATATCCTGCGAGTATTGCATACTGCACAGAAGTGGCCATAG

Antitoxin


Download         Length: 90 a.a.        Molecular weight: 10210.55 Da        Isoelectric Point: 8.8735

>AT57278 WP_000079946.1 NZ_CP012835:15443-15712 [Salmonella enterica subsp. enterica serovar Cerro str. CFSAN001588]
MAQVNMSLRIDAELKDAFMAAAKSMDRNGSQLIRDFMRQTVERQHNTWFRDQVEAGRQQLGRGDVLPHDMVESSATAWRD
EMSRKVAGK

Download         Length: 270 bp

>AT57278 NZ_CP012835:15443-15712 [Salmonella enterica subsp. enterica serovar Cerro str. CFSAN001588]
ATGGCACAGGTTAATATGAGTTTAAGAATCGACGCTGAACTGAAGGATGCTTTTATGGCCGCTGCAAAAAGCATGGACCG
TAATGGCTCTCAGTTAATCCGGGATTTTATGCGCCAGACCGTTGAACGGCAGCATAATACCTGGTTCCGTGACCAGGTTG
AGGCAGGACGTCAGCAACTCGGGCGCGGTGATGTGCTTCCACATGACATGGTCGAATCCTCCGCGACTGCATGGCGGGAT
GAAATGAGCAGAAAGGTTGCCGGTAAATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB E9LLH3

Antitoxin

Source ID Structure
AlphaFold DB A0A7U8WKC6

References