Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) phd-doc/HTH_IclR(antitoxin)
Location 5081390..5083107 Replicon chromosome
Accession NZ_CP012830
Organism Pseudomonas fluorescens strain FW300-N2E3

Toxin (Protein)


Gene name doc Uniprot ID A0A2N8C928
Locus tag AO353_RS23160 Protein ID WP_054597069.1
Coordinates 5082223..5083107 (-) Length 295 a.a.

Antitoxin (Protein)


Gene name phd Uniprot ID -
Locus tag AO353_RS23155 Protein ID WP_081013801.1
Coordinates 5081390..5082226 (-) Length 279 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
AO353_RS23135 5076595..5078091 - 1497 WP_054597065.1 aldehyde dehydrogenase -
AO353_RS23140 5078102..5078905 - 804 WP_054597066.1 aspartate dehydrogenase -
AO353_RS23145 5078916..5080598 - 1683 WP_054597067.1 thiamine pyrophosphate-binding protein -
AO353_RS23150 5080591..5081388 - 798 WP_054597068.1 SDR family oxidoreductase -
AO353_RS23155 5081390..5082226 - 837 WP_081013801.1 IclR family transcriptional regulator Antitoxin
AO353_RS23160 5082223..5083107 - 885 WP_054597069.1 alpha/beta hydrolase Toxin
AO353_RS23165 5083112..5083675 - 564 WP_054597070.1 cupin domain-containing protein -
AO353_RS23170 5083689..5084456 - 768 WP_173859995.1 SDR family oxidoreductase -
AO353_RS23175 5084453..5085229 - 777 WP_054597071.1 ABC transporter permease -
AO353_RS23180 5085258..5086259 - 1002 WP_054597072.1 ABC transporter substrate-binding protein -
AO353_RS23185 5086299..5087150 - 852 WP_081013802.1 ABC transporter ATP-binding protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Alpha/beta hydrolase fold-1

(47-278)

Antitoxin

Transcription regulator IclR, N-terminal

(19-68)


Sequences

Toxin        


Download         Length: 295 a.a.        Molecular weight: 31307.91 Da        Isoelectric Point: 7.2006

>T57258 WP_054597069.1 NZ_CP012830:c5083107-5082223 [Pseudomonas fluorescens]
MSYAIDNLVPPLTADLQAQLALHFPLRTLGIAGGRQAFRECGTGPAIVLLHGIGSGSASWLEVAQALGQSAHVIAWDAPG
YGDSTPLRSLAPDASDYAERLLQMLDALGIQRCVLVGHSLGAITATAFASGVHQQRISRLVLISPARGYGHPSRALQRQE
VRSKRLQALEQLGIQRMAEQRSAYMLSPTASPKAHAWVQWNMARLNPDGYRQAIELLCSEDLLRHAPLSMPCEVHCGEAD
GITAPENCLTLAKALGGTFNLITDAGHASPIEQPCVVAGRLAFAIKESLTGASL

Download         Length: 885 bp

>T57258 NZ_CP012830:c5083107-5082223 [Pseudomonas fluorescens]
ATGTCGTACGCCATCGATAATCTCGTCCCGCCGCTCACGGCTGACCTCCAGGCGCAGCTGGCCCTGCACTTTCCTTTGCG
TACGCTGGGGATCGCTGGCGGTCGCCAGGCCTTTCGCGAATGTGGAACCGGGCCGGCGATTGTGTTGTTGCACGGGATCG
GCTCGGGCTCGGCGTCGTGGTTAGAGGTGGCGCAAGCGCTTGGCCAGAGCGCACATGTGATTGCCTGGGACGCTCCCGGC
TACGGTGACTCCACGCCGCTGAGATCGTTGGCCCCCGACGCTTCGGACTACGCCGAACGACTGCTGCAGATGCTCGATGC
GCTAGGCATCCAGCGCTGTGTGCTGGTCGGTCACTCGCTCGGGGCGATTACTGCCACAGCGTTCGCCAGCGGCGTGCACC
AACAGCGGATCAGCCGGCTGGTGTTGATCAGTCCGGCCCGGGGCTACGGTCATCCATCGCGCGCCTTGCAGCGCCAGGAA
GTGCGCAGCAAACGCCTGCAAGCCCTGGAACAACTGGGCATTCAACGCATGGCCGAACAACGCAGCGCCTACATGCTTTC
GCCCACTGCCAGCCCCAAGGCACACGCCTGGGTGCAGTGGAACATGGCCCGGCTCAATCCCGATGGCTATCGCCAGGCCA
TAGAACTGCTGTGCAGCGAGGACCTGCTGCGGCACGCGCCACTGTCGATGCCTTGCGAAGTGCATTGCGGCGAAGCCGAC
GGCATCACCGCGCCCGAAAACTGCCTGACCCTGGCCAAGGCCTTGGGAGGCACGTTCAACCTGATTACCGATGCCGGGCA
TGCCAGCCCCATCGAACAACCTTGTGTGGTGGCGGGCCGCTTGGCCTTTGCCATCAAAGAATCCCTGACAGGTGCATCGC
TATGA

Antitoxin


Download         Length: 279 a.a.        Molecular weight: 30939.50 Da        Isoelectric Point: 6.3483

>AT57258 WP_081013801.1 NZ_CP012830:c5082226-5081390 [Pseudomonas fluorescens]
MNDSDLLKDAQDKYIVPGLERGLLLLCEFSRRNRTLTAPELARRLALPRSTIFRLLTTLETMGFVTRSGNEYRLGMSVLR
LGFEYLASLELTELGQPLLARLCDRLNYPSNLVVRDGRSIVYVAKVSPPSVFSNAVNVGTRLPAHATVLGRILLEDLSLA
ELRELYPEDHLEQFSPCTPKTVLELFDMVQADRQRGFVSSEGFFESAISTVAAPVRDQTGHIVAALGVTIPTVQIGHVNF
NELLLQVRRSADELSRLLDYNSAAAHDGQNRVTALMRD

Download         Length: 837 bp

>AT57258 NZ_CP012830:c5082226-5081390 [Pseudomonas fluorescens]
ATGAACGATTCAGATCTGCTGAAGGATGCTCAGGACAAGTACATCGTGCCGGGCCTGGAGCGCGGATTGCTGCTGCTCTG
CGAGTTCAGCCGGCGCAATCGCACGTTGACCGCGCCGGAACTGGCCCGGCGCCTGGCACTGCCGCGCTCGACGATCTTTC
GCCTGCTGACGACACTGGAAACCATGGGGTTTGTCACCCGCAGCGGCAATGAATACCGCCTTGGCATGTCGGTGCTGCGC
CTGGGCTTCGAGTACCTGGCCTCGCTGGAGCTGACCGAACTCGGCCAACCGCTGCTGGCCCGTTTGTGCGACCGCCTCAA
CTACCCGAGCAATCTGGTGGTGCGCGATGGCCGCTCGATCGTCTACGTGGCCAAAGTCTCGCCGCCCTCGGTGTTCTCCA
ACGCGGTGAATGTCGGCACTCGCCTCCCCGCCCACGCCACTGTCCTGGGGCGCATTCTGCTCGAAGACCTGTCGCTGGCC
GAATTGCGTGAACTGTACCCGGAAGATCACCTGGAGCAGTTTTCGCCCTGCACGCCGAAAACCGTGCTGGAGCTGTTTGA
CATGGTTCAAGCCGACCGTCAGCGCGGTTTCGTCAGTAGCGAAGGTTTCTTCGAGTCAGCGATTTCGACCGTCGCCGCCC
CGGTGCGCGATCAGACCGGGCATATCGTCGCTGCACTGGGCGTGACGATTCCGACCGTTCAGATCGGTCACGTCAACTTC
AACGAATTGCTCCTGCAGGTGCGTCGCAGTGCCGACGAGCTGTCGCGGTTGCTCGACTACAACAGCGCTGCCGCCCACGA
CGGCCAGAACCGCGTAACAGCCTTGATGAGGGATTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2N8C928

Antitoxin

Source ID Structure

References