Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) /Xre(antitoxin)
Location 2228278..2229410 Replicon chromosome
Accession NZ_CP012808
Organism Acinetobacter equi strain 114

Toxin (Protein)


Gene name - Uniprot ID A0A0N9V9I8
Locus tag AOY20_RS10630 Protein ID WP_054581836.1
Coordinates 2228278..2229042 (-) Length 255 a.a.

Antitoxin (Protein)


Gene name - Uniprot ID A0A0N9VXE5
Locus tag AOY20_RS10635 Protein ID WP_054581837.1
Coordinates 2229039..2229410 (-) Length 124 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
AOY20_RS10605 2223743..2223976 + 234 WP_144424778.1 hypothetical protein -
AOY20_RS10610 2224304..2225224 - 921 WP_054581832.1 ornithine carbamoyltransferase -
AOY20_RS10615 2225328..2225978 - 651 WP_054581833.1 TetR/AcrR family transcriptional regulator -
AOY20_RS10620 2226192..2227076 + 885 WP_054581834.1 methylisocitrate lyase -
AOY20_RS10625 2227081..2228211 + 1131 WP_054581835.1 2-methylcitrate synthase -
AOY20_RS10630 2228278..2229042 - 765 WP_054581836.1 RES family NAD+ phosphorylase Toxin
AOY20_RS10635 2229039..2229410 - 372 WP_054581837.1 MbcA/ParS/Xre antitoxin family protein Antitoxin
AOY20_RS10640 2229676..2229909 + 234 WP_054582589.1 hypothetical protein -
AOY20_RS10645 2230419..2230631 + 213 WP_054581838.1 hypothetical protein -
AOY20_RS10650 2230967..2232280 + 1314 WP_081403386.1 formylglycine-generating enzyme family protein -
AOY20_RS10655 2232632..2233816 + 1185 WP_054581840.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

RES domain

(66-217)

Antitoxin

Antitoxin Xre/MbcA/ParS-like, toxin-binding domain

(72-121)


Sequences

Toxin        


Download         Length: 255 a.a.        Molecular weight: 29544.70 Da        Isoelectric Point: 6.5977

>T57253 WP_054581836.1 NZ_CP012808:c2229042-2228278 [Acinetobacter equi]
MTVQDSNIWQSCNAEKLIEPIKGTLYRMIESQEQIATRNLVDSLEEQSLLEEMLEEIKPTYPLGIENLHYLLKTPFRYPP
LKWGSRFGRTHEPSIFYGGCSPEATLAESAYYRFVFWYSMQSTAPKSLIKTNHTMFSVKYQTKYGIRLQSKAFHQYKSVL
QHPKNYHATQQLGTAMREAGVELFEYASARDHQNLLCVGLFNAKPFCSKAPEYKQEWFCNLEETQVTFKNLDTAQIYCFE
LSQFLIQDELPLPA

Download         Length: 765 bp

>T57253 NZ_CP012808:c2229042-2228278 [Acinetobacter equi]
ATGACGGTACAAGATAGTAATATTTGGCAATCCTGTAATGCAGAAAAACTTATTGAACCCATTAAAGGTACACTTTATCG
GATGATTGAAAGTCAAGAACAAATTGCTACACGCAATTTAGTTGACTCCTTAGAAGAGCAATCATTACTTGAAGAAATGC
TTGAAGAAATAAAGCCAACGTATCCATTAGGTATAGAAAATTTACATTATTTATTAAAAACACCCTTCCGTTACCCCCCT
TTAAAATGGGGATCTCGCTTTGGTCGCACTCATGAACCAAGTATTTTTTATGGAGGATGTAGCCCTGAAGCGACTTTAGC
TGAGTCAGCTTATTATCGATTTGTCTTTTGGTATTCCATGCAGTCCACAGCACCAAAATCATTAATTAAAACAAATCACA
CAATGTTTTCAGTTAAATATCAAACAAAATATGGCATTCGACTTCAAAGTAAAGCATTTCATCAATATAAATCTGTTTTA
CAACATCCTAAAAATTATCATGCAACACAACAATTAGGCACAGCAATGAGAGAAGCTGGAGTAGAATTATTTGAATATGC
ATCTGCTAGAGATCACCAAAACCTACTTTGTGTTGGCTTATTCAATGCAAAACCATTTTGTTCAAAAGCTCCAGAATATA
AACAGGAATGGTTTTGTAACTTGGAAGAAACTCAAGTAACGTTTAAGAATCTTGATACTGCGCAAATTTATTGTTTTGAA
CTTTCACAATTTTTAATTCAAGATGAACTTCCTCTTCCTGCATAA

Antitoxin


Download         Length: 124 a.a.        Molecular weight: 13547.99 Da        Isoelectric Point: 10.7562

>AT57253 WP_054581837.1 NZ_CP012808:c2229410-2229039 [Acinetobacter equi]
MTAILKPAPNKNMVLAKAVLNIAEQLHLTQSELGAIIGMHRTAISKLNAHPNIDPHSKSGELALLLIRFYRALYALTGGD
QVWMRHFINTQNKITGDIPKNQMKTITGLVTVLQTVDALRGKI

Download         Length: 372 bp

>AT57253 NZ_CP012808:c2229410-2229039 [Acinetobacter equi]
ATGACAGCTATTCTAAAACCTGCTCCAAATAAAAATATGGTATTAGCTAAAGCTGTTCTCAATATTGCAGAACAACTTCA
TCTTACTCAAAGTGAATTAGGTGCAATTATTGGTATGCATCGTACAGCTATAAGTAAATTAAATGCCCATCCCAATATTG
ATCCTCATTCAAAAAGTGGTGAACTTGCTTTGCTTCTTATCCGTTTTTATCGTGCTTTATACGCATTAACTGGTGGTGAC
CAAGTTTGGATGCGTCATTTTATTAATACACAAAATAAAATAACAGGTGACATTCCTAAAAATCAAATGAAAACCATTAC
GGGTTTAGTTACTGTTCTACAGACAGTAGATGCTTTACGAGGAAAAATATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0N9V9I8

Antitoxin

Source ID Structure
AlphaFold DB A0A0N9VXE5

References