Detailed information of TA system TA057250

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): sezT-pezT/zeta-couple_hipB
• Location: 1208026..1209284
• Replicon: chromosome
• Accession: NZ_CP012805
• Organism: Streptococcus anginosus strain J4211

Toxin (Protein)

• Gene name: sezT
• Uniprot ID: -
• Locus tag: SanJ4211_RS06055
• Protein ID: WP_057489708.1
• Coordinates: 1208026..1208808 (-)
• Length: 261 a.a.

Antitoxin (Protein)

• Gene name: pezT
• Uniprot ID: A0A0P0N8Y9
• Locus tag: SanJ4211_RS06060
• Protein ID: WP_049512045.1
• Coordinates: 1208808..1209284 (-)
• Length: 159 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
SanJ4211_RS06030	1203161..1205038	-	1878	WP_049512052.1	relaxase/mobilization nuclease domain-containing protein	-
SanJ4211_RS06035	1205025..1205390	-	366	WP_049512050.1	MobC family plasmid mobilization relaxosome protein	-
SanJ4211_RS06040	1205400..1205759	-	360	WP_049512285.1	hypothetical protein	-
SanJ4211_RS06045	1206098..1207240	-	1143	WP_049512049.1	AAA family ATPase	-
SanJ4211_RS06050	1207241..1208029	-	789	WP_049476721.1	hypothetical protein	-
SanJ4211_RS06055	1208026..1208808	-	783	WP_057489708.1	zeta toxin family protein	Toxin
SanJ4211_RS06060	1208808..1209284	-	477	WP_049512045.1	helix-turn-helix domain-containing protein	Antitoxin
SanJ4211_RS06065	1209354..1209641	-	288	WP_049476718.1	hypothetical protein	-
SanJ4211_RS06070	1209686..1210075	-	390	WP_049512043.1	hypothetical protein	-
SanJ4211_RS06075	1210072..1210299	-	228	WP_007520115.1	hypothetical protein	-
SanJ4211_RS06080	1210354..1211442	-	1089	WP_049512042.1	toprim domain-containing protein	-
SanJ4211_RS06085	1211481..1212119	-	639	WP_024052550.1	hypothetical protein	-
SanJ4211_RS06090	1212215..1212505	-	291	WP_024052551.1	hypothetical protein	-
SanJ4211_RS06095	1212521..1212820	-	300	WP_049512039.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Zeta toxin domain (28-215)

Antitoxin

• Cro/C1-type helix-turn-helix domain (3-60)

Sequences

Toxin

Protein

• Length: 261 a.a.
• Molecular weight: 29679.88 Da
• Isoelectric Point: 7.9056

>T57250 WP_057489708.1 NZ_CP012805:c1208808-1208026 [Streptococcus anginosus]
MRLEEFSEDEFQKALQRTIRALTRGKTIPDQPKAILLGGQSGAGKTTIHRIKQKEFQGNIVIIDGDSYRSQHPNYLALQE
KYGKDSVDYTKGFTGKMVEHLVDELSIQGYHLLIEGTLRTTEVPRKTTQLLKSRGYQVSLALIATKPELSYLSTLICYEE
VYAVNPSQTRATPKEYHDGIVDHLVDNLRELENDKLFDRIQIYQRDRTCIYDSETDEGAAAEVLQKSLFGKWSKVEKEMM
KMGKEKLANLVDKNMIGSKK

Nucleotide

• Length: 783 bp

>T57250 NZ_CP012805:c1208808-1208026 [Streptococcus anginosus]
ATGAGACTGGAAGAATTTAGTGAGGATGAATTTCAGAAAGCCTTACAGCGAACGATTCGAGCTCTAACTCGTGGAAAGAC
GATTCCAGACCAACCTAAAGCCATCTTGCTTGGTGGTCAAAGCGGAGCAGGAAAGACGACTATTCATCGAATTAAACAAA
AAGAATTTCAGGGAAATATCGTTATCATTGACGGTGATAGCTATCGTTCTCAGCACCCAAATTACTTAGCTCTGCAAGAA
AAGTATGGTAAAGATAGTGTGGACTACACCAAGGGATTTACAGGAAAAATGGTAGAGCATCTGGTTGATGAACTCAGCAT
ACAAGGCTATCATTTGTTAATTGAAGGAACTTTGAGAACGACGGAAGTCCCAAGAAAAACTACACAGCTATTAAAATCAA
GGGGATACCAAGTCTCGTTAGCCTTGATAGCCACCAAGCCTGAATTGTCTTATCTCAGCACCTTAATCTGTTACGAAGAA
GTCTATGCAGTAAATCCAAGCCAAACTAGAGCAACACCTAAAGAGTACCATGATGGTATTGTGGACCATTTGGTTGATAA
TCTAAGAGAGTTAGAAAACGATAAACTCTTTGACCGCATTCAAATTTATCAAAGAGATAGGACTTGCATTTACGATTCTG
AAACGGATGAGGGGGCAGCAGCAGAAGTTCTTCAAAAATCTCTCTTCGGTAAATGGAGTAAGGTTGAGAAAGAGATGATG
AAGATGGGAAAAGAAAAATTAGCTAACTTAGTAGATAAGAATATGATTGGGAGTAAGAAATGA

Antitoxin

Protein

• Length: 159 a.a.
• Molecular weight: 18288.65 Da
• Isoelectric Point: 4.3971

>AT57250 WP_049512045.1 NZ_CP012805:c1209284-1208808 [Streptococcus anginosus]
MIGDNIKSLRRTHDLTQPEFAKIVGISRNSLSRYENGTSTVSTELIDRICQKFNVSYVDIVGEDKMLTPVEDYQLTLKVE
VIKERGAAILSQLYRYQDSQDIAFDDETNPWILMSDDLAELIHTKIYLVDTFDEIERYNGYLDGIERMLDTVYHRVVA

Nucleotide

• Length: 477 bp

>AT57250 NZ_CP012805:c1209284-1208808 [Streptococcus anginosus]
ATGATTGGAGATAATATTAAGTCCTTACGCAGAACTCATGATCTAACCCAGCCAGAATTCGCAAAAATTGTTGGGATTTC
ACGCAATAGCTTAAGTCGATATGAAAATGGAACTAGCACGGTTTCAACAGAACTCATCGACCGAATTTGTCAGAAATTTA
ATGTTTCATACGTTGATATTGTAGGGGAGGACAAAATGTTAACACCTGTTGAAGATTACCAACTAACCTTAAAAGTAGAA
GTGATTAAAGAACGTGGAGCAGCCATTCTATCCCAACTCTATCGCTACCAAGATAGTCAGGATATTGCTTTTGATGACGA
AACTAATCCTTGGATTTTGATGAGCGACGATCTGGCTGAATTGATCCATACAAAGATTTACCTTGTTGATACTTTCGATG
AAATAGAGCGTTATAATGGCTATTTAGACGGTATAGAGCGGATGTTAGACACGGTGTATCATCGGGTGGTGGCTTGA

Structures

Antitoxin

• AlphaFold DB: A0A0P0N8Y9