Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) paaR-paaA-parE/-
Location 1167279..1167757 Replicon chromosome
Accession NZ_CP012802
Organism Escherichia coli O157:H7 strain WS4202

Toxin (Protein)


Gene name parE_1 Uniprot ID A0A891SFN9
Locus tag AO055_RS05560 Protein ID WP_001303876.1
Coordinates 1167279..1167566 (-) Length 96 a.a.

Antitoxin (Protein)


Gene name paaA Uniprot ID Q8XD67
Locus tag AO055_RS05565 Protein ID WP_000536233.1
Coordinates 1167566..1167757 (-) Length 64 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
AO055_RS05525 1162428..1164899 - 2472 WP_000034474.1 exonuclease -
AO055_RS05530 1164993..1165184 - 192 WP_001098307.1 DUF1482 family protein -
AO055_RS30070 1165181..1165369 - 189 WP_000413705.1 cell division inhibition protein DicB -
AO055_RS05545 1165943..1166128 + 186 WP_001133046.1 hypothetical protein -
AO055_RS05550 1166315..1166704 - 390 WP_000394511.1 hypothetical protein -
AO055_RS05555 1166846..1167001 - 156 WP_000379575.1 DUF1391 family protein -
AO055_RS05560 1167279..1167566 - 288 WP_001303876.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
AO055_RS05565 1167566..1167757 - 192 WP_000536233.1 hypothetical protein Antitoxin
AO055_RS05570 1167785..1168186 - 402 WP_000986592.1 helix-turn-helix domain-containing protein -
AO055_RS05575 1168295..1168567 + 273 WP_000887453.1 helix-turn-helix domain-containing protein -
AO055_RS05580 1168551..1168976 + 426 WP_000693855.1 Rha family transcriptional regulator -
AO055_RS30085 1169183..1169638 - 456 WP_000273724.1 hypothetical protein -
AO055_RS05590 1169717..1170808 + 1092 WP_001205823.1 hypothetical protein -
AO055_RS05595 1170815..1171561 + 747 WP_000788751.1 ATP-binding protein -
AO055_RS05600 1171583..1172353 + 771 WP_000450992.1 DUF1627 domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(4-91)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 96 a.a.        Molecular weight: 10978.84 Da        Isoelectric Point: 10.1360

>T57213 WP_001303876.1 NZ_CP012802:c1167566-1167279 [Escherichia coli O157:H7]
MLPILWLPSARDDLRQIITYIAKENPPAARRLKIRIETSVLPLSEHPYLYPPSERVSGLREIVTHPNYIILYRVAASSIE
IVSVTHSRRQFPFSI

Download         Length: 288 bp

>T57213 NZ_CP012802:c1167566-1167279 [Escherichia coli O157:H7]
ATGTTACCCATTTTATGGCTACCGTCTGCTCGCGATGATTTGCGCCAGATCATAACTTACATCGCCAAGGAGAACCCACC
GGCAGCACGTAGACTAAAAATACGCATTGAAACATCGGTATTACCTCTATCTGAGCATCCGTACTTATATCCACCAAGCG
AACGGGTTTCTGGATTGAGAGAGATCGTGACCCACCCTAACTACATAATCCTGTACAGAGTAGCTGCTTCAAGCATTGAG
ATTGTAAGCGTGACACATTCTCGGCGACAATTTCCCTTCTCTATCTGA

Antitoxin


Download         Length: 64 a.a.        Molecular weight: 7025.80 Da        Isoelectric Point: 4.0270

>AT57213 WP_000536233.1 NZ_CP012802:c1167757-1167566 [Escherichia coli O157:H7]
MGTALSPIVSEFETTEQENSYNEWLRTKVTSSLADTRPAIPHDEVMAEMENLIAQIAVTNKSE

Download         Length: 192 bp

>AT57213 NZ_CP012802:c1167757-1167566 [Escherichia coli O157:H7]
ATGGGTACAGCCCTTTCTCCGATAGTTTCAGAATTCGAAACTACCGAACAAGAAAACAGTTACAACGAATGGTTGCGCAC
TAAAGTAACGTCAAGCCTTGCAGACACTCGCCCCGCAATTCCACATGACGAGGTAATGGCTGAAATGGAAAATCTTATTG
CTCAAATTGCTGTAACTAACAAGAGCGAGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References