Detailed information of TA system
Bioinformatically predictedOverview
TA module
Type | II | Classification (family/domain) | paaR-paaA-parE/- |
Location | 1167279..1167757 | Replicon | chromosome |
Accession | NZ_CP012802 | ||
Organism | Escherichia coli O157:H7 strain WS4202 |
Toxin (Protein)
Gene name | parE_1 | Uniprot ID | A0A891SFN9 |
Locus tag | AO055_RS05560 | Protein ID | WP_001303876.1 |
Coordinates | 1167279..1167566 (-) | Length | 96 a.a. |
Antitoxin (Protein)
Gene name | paaA | Uniprot ID | Q8XD67 |
Locus tag | AO055_RS05565 | Protein ID | WP_000536233.1 |
Coordinates | 1167566..1167757 (-) | Length | 64 a.a. |
Genomic Context
Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
---|---|---|---|---|---|---|
AO055_RS05525 | 1162428..1164899 | - | 2472 | WP_000034474.1 | exonuclease | - |
AO055_RS05530 | 1164993..1165184 | - | 192 | WP_001098307.1 | DUF1482 family protein | - |
AO055_RS30070 | 1165181..1165369 | - | 189 | WP_000413705.1 | cell division inhibition protein DicB | - |
AO055_RS05545 | 1165943..1166128 | + | 186 | WP_001133046.1 | hypothetical protein | - |
AO055_RS05550 | 1166315..1166704 | - | 390 | WP_000394511.1 | hypothetical protein | - |
AO055_RS05555 | 1166846..1167001 | - | 156 | WP_000379575.1 | DUF1391 family protein | - |
AO055_RS05560 | 1167279..1167566 | - | 288 | WP_001303876.1 | type II toxin-antitoxin system RelE/ParE family toxin | Toxin |
AO055_RS05565 | 1167566..1167757 | - | 192 | WP_000536233.1 | hypothetical protein | Antitoxin |
AO055_RS05570 | 1167785..1168186 | - | 402 | WP_000986592.1 | helix-turn-helix domain-containing protein | - |
AO055_RS05575 | 1168295..1168567 | + | 273 | WP_000887453.1 | helix-turn-helix domain-containing protein | - |
AO055_RS05580 | 1168551..1168976 | + | 426 | WP_000693855.1 | Rha family transcriptional regulator | - |
AO055_RS30085 | 1169183..1169638 | - | 456 | WP_000273724.1 | hypothetical protein | - |
AO055_RS05590 | 1169717..1170808 | + | 1092 | WP_001205823.1 | hypothetical protein | - |
AO055_RS05595 | 1170815..1171561 | + | 747 | WP_000788751.1 | ATP-binding protein | - |
AO055_RS05600 | 1171583..1172353 | + | 771 | WP_000450992.1 | DUF1627 domain-containing protein | - |
Associated MGEs
MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 96 a.a. Molecular weight: 10978.84 Da Isoelectric Point: 10.1360
>T57213 WP_001303876.1 NZ_CP012802:c1167566-1167279 [Escherichia coli O157:H7]
MLPILWLPSARDDLRQIITYIAKENPPAARRLKIRIETSVLPLSEHPYLYPPSERVSGLREIVTHPNYIILYRVAASSIE
IVSVTHSRRQFPFSI
MLPILWLPSARDDLRQIITYIAKENPPAARRLKIRIETSVLPLSEHPYLYPPSERVSGLREIVTHPNYIILYRVAASSIE
IVSVTHSRRQFPFSI
Download Length: 288 bp
>T57213 NZ_CP012802:c1167566-1167279 [Escherichia coli O157:H7]
ATGTTACCCATTTTATGGCTACCGTCTGCTCGCGATGATTTGCGCCAGATCATAACTTACATCGCCAAGGAGAACCCACC
GGCAGCACGTAGACTAAAAATACGCATTGAAACATCGGTATTACCTCTATCTGAGCATCCGTACTTATATCCACCAAGCG
AACGGGTTTCTGGATTGAGAGAGATCGTGACCCACCCTAACTACATAATCCTGTACAGAGTAGCTGCTTCAAGCATTGAG
ATTGTAAGCGTGACACATTCTCGGCGACAATTTCCCTTCTCTATCTGA
ATGTTACCCATTTTATGGCTACCGTCTGCTCGCGATGATTTGCGCCAGATCATAACTTACATCGCCAAGGAGAACCCACC
GGCAGCACGTAGACTAAAAATACGCATTGAAACATCGGTATTACCTCTATCTGAGCATCCGTACTTATATCCACCAAGCG
AACGGGTTTCTGGATTGAGAGAGATCGTGACCCACCCTAACTACATAATCCTGTACAGAGTAGCTGCTTCAAGCATTGAG
ATTGTAAGCGTGACACATTCTCGGCGACAATTTCCCTTCTCTATCTGA
Antitoxin
Download Length: 64 a.a. Molecular weight: 7025.80 Da Isoelectric Point: 4.0270
>AT57213 WP_000536233.1 NZ_CP012802:c1167757-1167566 [Escherichia coli O157:H7]
MGTALSPIVSEFETTEQENSYNEWLRTKVTSSLADTRPAIPHDEVMAEMENLIAQIAVTNKSE
MGTALSPIVSEFETTEQENSYNEWLRTKVTSSLADTRPAIPHDEVMAEMENLIAQIAVTNKSE
Download Length: 192 bp
>AT57213 NZ_CP012802:c1167757-1167566 [Escherichia coli O157:H7]
ATGGGTACAGCCCTTTCTCCGATAGTTTCAGAATTCGAAACTACCGAACAAGAAAACAGTTACAACGAATGGTTGCGCAC
TAAAGTAACGTCAAGCCTTGCAGACACTCGCCCCGCAATTCCACATGACGAGGTAATGGCTGAAATGGAAAATCTTATTG
CTCAAATTGCTGTAACTAACAAGAGCGAGTAA
ATGGGTACAGCCCTTTCTCCGATAGTTTCAGAATTCGAAACTACCGAACAAGAAAACAGTTACAACGAATGGTTGCGCAC
TAAAGTAACGTCAAGCCTTGCAGACACTCGCCCCGCAATTCCACATGACGAGGTAATGGCTGAAATGGAAAATCTTATTG
CTCAAATTGCTGTAACTAACAAGAGCGAGTAA
Similar Proteins
Only experimentally validated proteins are listed.
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
---|
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
---|
Structures
Toxin
Source | ID | Structure |
---|
Antitoxin
Source | ID | Structure |
---|