Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/-
Location 828386..828999 Replicon chromosome
Accession NZ_CP012801
Organism Bacteroides cellulosilyticus strain WH2

Toxin (Protein)


Gene name hicA Uniprot ID A0A0P0GBE3
Locus tag BcellWH2_RS03935 Protein ID WP_025726569.1
Coordinates 828739..828999 (-) Length 87 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID A0A0P0GJ23
Locus tag BcellWH2_RS03930 Protein ID WP_025726570.1
Coordinates 828386..828727 (-) Length 114 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
BcellWH2_RS03885 823795..824187 - 393 WP_029429237.1 hypothetical protein -
BcellWH2_RS03890 824184..824482 - 299 Protein_772 hypothetical protein -
BcellWH2_RS03895 824473..824796 - 324 WP_029429236.1 hypothetical protein -
BcellWH2_RS03900 824799..825137 - 339 WP_029428572.1 hypothetical protein -
BcellWH2_RS03905 825134..825475 - 342 WP_029428571.1 hypothetical protein -
BcellWH2_RS03910 825472..826560 - 1089 WP_029428570.1 major capsid protein -
BcellWH2_RS03915 826564..826965 - 402 WP_029428569.1 hypothetical protein -
BcellWH2_RS03920 826980..827675 - 696 WP_052332032.1 hypothetical protein -
BcellWH2_RS03925 827976..828386 - 411 WP_029428567.1 hypothetical protein -
BcellWH2_RS03930 828386..828727 - 342 WP_025726570.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
BcellWH2_RS03935 828739..828999 - 261 WP_025726569.1 type II toxin-antitoxin system HicA family toxin Toxin
BcellWH2_RS03940 829182..830567 - 1386 WP_029428566.1 phage portal protein -
BcellWH2_RS03945 830579..831802 - 1224 WP_029428565.1 PBSX family phage terminase large subunit -
BcellWH2_RS03950 831795..832247 - 453 WP_144430724.1 hypothetical protein -
BcellWH2_RS03955 832432..832953 - 522 WP_029428563.1 hypothetical protein -
BcellWH2_RS03960 832956..833216 - 261 WP_029428562.1 hypothetical protein -
BcellWH2_RS03965 833228..833494 - 267 WP_144430725.1 hypothetical protein -
BcellWH2_RS03970 833566..833901 - 336 WP_029428560.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(20-79)

Antitoxin

Uncharacterised protein family HicB

(55-105)


Sequences

Toxin        


Download         Length: 87 a.a.        Molecular weight: 9919.54 Da        Isoelectric Point: 10.2532

>T57207 WP_025726569.1 NZ_CP012801:c828999-828739 [Bacteroides cellulosilyticus]
MGTKEKLIDRFCKLPKDFTYEETLKLLSAFGYSEHNKGATSGSRVRFKNEQTGQYIDIHKPHPGSIMKAWMMKAIYQHLK
SNGLIK

Download         Length: 261 bp

>T57207 NZ_CP012801:c828999-828739 [Bacteroides cellulosilyticus]
ATGGGTACTAAAGAAAAGTTGATAGACCGTTTTTGCAAACTACCTAAAGACTTCACTTATGAAGAAACTTTGAAGTTGCT
TTCTGCCTTTGGATATAGTGAACATAATAAAGGTGCGACATCTGGTTCTCGTGTAAGATTTAAAAATGAACAAACGGGAC
AGTATATTGATATACATAAGCCGCATCCGGGTAGTATCATGAAAGCATGGATGATGAAAGCGATATATCAGCATTTAAAA
AGTAACGGTTTAATTAAATAA

Antitoxin


Download         Length: 114 a.a.        Molecular weight: 12465.12 Da        Isoelectric Point: 4.8781

>AT57207 WP_025726570.1 NZ_CP012801:c828727-828386 [Bacteroides cellulosilyticus]
MDYLEYKGYKGSVEYSKADNCLFGKVLGMSKDLILYEGNTIDELRADFEAGIESYLAGCLADGVEPRKPYSGTLNIRISP
EIHSRIASLAQEAGTTINGYIKQALENQLKLAH

Download         Length: 342 bp

>AT57207 NZ_CP012801:c828727-828386 [Bacteroides cellulosilyticus]
ATGGACTACTTGGAATACAAAGGATATAAAGGTTCAGTTGAGTACAGCAAAGCTGATAACTGCCTATTTGGAAAGGTGCT
TGGAATGAGTAAGGATTTGATTCTTTATGAAGGAAACACCATTGATGAACTTCGTGCTGATTTTGAAGCCGGAATAGAAA
GCTATCTTGCAGGTTGTTTGGCTGATGGAGTGGAACCGCGTAAACCATATAGTGGTACATTGAATATCCGTATTTCGCCG
GAGATTCATAGTCGGATTGCTTCACTTGCACAAGAAGCAGGAACAACTATTAATGGTTATATAAAACAGGCATTGGAGAA
TCAACTTAAATTAGCACATTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0P0GBE3

Antitoxin

Source ID Structure
AlphaFold DB A0A0P0GJ23

References